RAT:Q2IBD1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein Wnt (ECO:0000256 with RuleBase:RU003500)
External Links
UniProt	Q2IBD1
EMBL	AABR06029880 DP000027 CH473959
RefSeq	XP_001059030.1 XP_575397.1
UniGene	Rn.223092
Ensembl	ENSRNOT00000010427
GeneID	114487
KEGG	rno:114487
CTD	7472
RGD	621346
eggNOG	NOG284879
GeneTree	ENSGT00760000118943
HOGENOM	HOG000039529
HOVERGEN	HBG001595
KO	K00182
OMA	GYDTSRI
OrthoDB	EOG7C8GJ8
TreeFam	TF105310
Reactome	REACT_198373 REACT_262688
NextBio	618503
PRO	PR:Q2IBD1
Proteomes	UP000002494
Genevestigator	Q2IBD1
GO	GO:0005737 GO:0005615 GO:0005886 GO:0005578 GO:0005109 GO:0055009 GO:0060070 GO:0060317 GO:0045165 GO:0071560 GO:0060716 GO:0030324 GO:0060492 GO:0061180 GO:0030182 GO:0090263 GO:0060045 GO:0001938 GO:0060501 GO:0048146 GO:0002053 GO:0051091 GO:0045944 GO:0016055
InterPro	IPR005817 IPR009140 IPR018161
PANTHER	PTHR12027
Pfam	PF00110
PRINTS	PR01842 PR01349
SMART	SM00097
PROSITE	PS00246

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0071542	dopaminergic neuron differentiation	PMID:20018874^[1]	ECO:0000314			P	Figure 3 shows Wnt2 increases the number of dopaminergic neurons from precursor cells.	complete CACAO 6647
	GO:0016055	Wnt receptor signaling pathway	PMID:20018874^[1]	ECO:0000314			P	Figure 2 shows Wnt2 activates the beta-Catenin/Wnt signaling pathway.	complete CACAO 6648
involved_in	GO:0030324	lung development	PMID:1377452^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17194898^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:18302287^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98957 PANTHER:PTN000246517 UniProtKB:P49339 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246517 RGD:69250 UniProtKB:P56706 UniProtKB:Q98SN7	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010194 MGI:MGI:108061 MGI:MGI:1197020 MGI:MGI:98953 MGI:MGI:98954 MGI:MGI:98956 MGI:MGI:98958 MGI:MGI:98960 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 UniProtKB:P41221 UniProtKB:Q98SN7 WB:WBGene00000858 WB:WBGene00003029 ZFIN:ZDB-GENE-980526-332	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 MGI:MGI:98956 MGI:MGI:98957 PANTHER:PTN000246517 RGD:1311441 RGD:69250 UniProtKB:P41221 UniProtKB:P56704 UniProtKB:P56705 UniProtKB:Q2LMP1 UniProtKB:Q9UBV4 UniProtKB:Q9YGX6	C	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004009 FB:FBgn0004360 FB:FBgn0010453 FB:FBgn0038134 MGI:MGI:98956 MGI:MGI:98957 MGI:MGI:98958 MGI:MGI:98961 MGI:MGI:98962 PANTHER:PTN000246517 RGD:69079 UniProtKB:P09544 UniProtKB:P41221 UniProtKB:P56703 UniProtKB:Q98SN7	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	C	Seeded From UniProt	complete
involved_in	GO:0061180	mammary gland epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:0033278	cell proliferation in midbrain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
part_of	GO:0031232	extrinsic component of external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	C	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	F	Seeded From UniProt	complete
enables	GO:0005109	frizzled binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09544 ensembl:ENSP00000265441	F	Seeded From UniProt	complete
involved_in	GO:0060716	labyrinthine layer blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0060492	lung induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0055009	atrial cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21552 ensembl:ENSMUSP00000010941	P	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005817 InterPro:IPR009140	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page
↑ Levay-Young, BK & Navre, M (1992) Growth and developmental regulation of wnt-2 (irp) gene in mesenchymal cells of fetal lung. Am. J. Physiol. 262 L672-83 PubMed GONUTS page
↑ Fujise, T et al. (2007) Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G1150-6 PubMed GONUTS page
↑ Klein, D et al. (2008) Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47 1018-31 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20018874-1] 1.0 ^1.1 Sousa, KM et al. (2010) Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J. Biol. Chem. 285 7246-53 PubMed GONUTS page

[PMID:1377452-2] Levay-Young, BK & Navre, M (1992) Growth and developmental regulation of wnt-2 (irp) gene in mesenchymal cells of fetal lung. Am. J. Physiol. 262 L672-83 PubMed GONUTS page

[PMID:17194898-3] Fujise, T et al. (2007) Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G1150-6 PubMed GONUTS page

[PMID:18302287-4] Klein, D et al. (2008) Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47 1018-31 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:Q2IBD1

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