RAT:PTN1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ptpn1
Protein Name(s)	Tyrosine-protein phosphatase non-receptor type 1 Protein-tyrosine phosphatase 1B PTP-1B
External Links
UniProt	P20417
EMBL	M33962 BC081829
PIR	A34845
RefSeq	NP_036769.1 XP_006235700.1
UniGene	Rn.11317
ProteinModelPortal	P20417
SMR	P20417
IntAct	P20417
STRING	10116.ENSRNOP00000014309
BindingDB	P20417
ChEMBL	CHEMBL2371
iPTMnet	P20417
PaxDb	P20417
PRIDE	P20417
Ensembl	ENSRNOT00000014309
GeneID	24697
KEGG	rno:24697
UCSC	RGD:61965
CTD	5770
RGD	61965
eggNOG	KOG0789 COG5599
GeneTree	ENSGT00770000120452
HOGENOM	HOG000273908
HOVERGEN	HBG008321
InParanoid	P20417
KO	K05696
OMA	DGPIKEE
OrthoDB	EOG7RV9G4
PhylomeDB	P20417
Reactome	R-RNO-354192 R-RNO-912694 R-RNO-982772
NextBio	604151
PRO	PR:P20417
Proteomes	UP000002494
GO	GO:0031225 GO:0098554 GO:0031410 GO:0005829 GO:0005769 GO:0005886 GO:0097443 GO:0005158 GO:0044822 GO:0051721 GO:0004725 GO:0008270 GO:0031532 GO:0007257 GO:0030968 GO:0008286 GO:0036498 GO:1902236 GO:0070373 GO:0043407 GO:1903898 GO:0030948 GO:1990264 GO:0035791 GO:0061098 GO:2000646 GO:0006470 GO:0030100 GO:1902202 GO:0046626 GO:0033157 GO:0009966
Gene3D	3.90.190.10
InterPro	IPR029021 IPR000242 IPR012265 IPR016130 IPR000387
Pfam	PF00102
PIRSF	PIRSF000926
PRINTS	PR00700
SMART	SM00194
SUPFAM	SSF52799
PROSITE	PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030061	mitochondrial crista	PMID:18583343^[1]	ECO:0000314			C	Figure 2 shows immunogold labeling of PTP-1B in isolated brain mitochondria. Figure 2A shows PTP-1B in the electron dense areas of the mitochondria, associated with the cristae.	complete CACAO 11813
	GO:0005759	mitochondrial matrix	PMID:18583343^[1]	ECO:0000314			C	Figure 2 shows immunogold labeling of PTP-1B in isolated brain mitochondria. Figure 2A shows PTP-1B in the electron dense areas of the mitochondria, associated with the matrix.	complete CACAO 11814
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18031	P	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18031	P	Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18031	P	Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18031	P	Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18031	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P18031	C	Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	PMID:17897622^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3380	F	Seeded From UniProt	complete
involved_in	GO:0046626	regulation of insulin receptor signaling pathway	PMID:12941932^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:17563729^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	PMID:2154749^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:17563729^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	PMID:7711057^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7711057^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:12850498^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:7711057^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:17563729^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:7711057^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A8K3M3 ensembl:ENSP00000360683	C	Seeded From UniProt	complete
involved_in	GO:2000646	positive regulation of receptor catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
involved_in	GO:1903898	negative regulation of PERK-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
involved_in	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
part_of	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	C	Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	F	Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
involved_in	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
involved_in	GO:0033157	regulation of intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	C	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	F	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
involved_in	GO:0030100	regulation of endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	F	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	F	Seeded From UniProt	complete
involved_in	GO:0009966	regulation of signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P18031 ensembl:ENSP00000360683	F	Seeded From UniProt	complete
involved_in	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:1903898	negative regulation of PERK-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
part_of	GO:0097443	sorting endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	C	Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	P	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35821 ensembl:ENSMUSP00000029053	C	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012265 InterPro:IPR016130	F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR012265	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F	Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Arachiche, A et al. (2008) Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences. J. Biol. Chem. 283 24406-11 PubMed GONUTS page
↑ Shi, K et al. (2007) Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression. Biochem. Biophys. Res. Commun. 363 626-32 PubMed GONUTS page
↑ Shimizu, S et al. (2003) Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression. J. Biol. Chem. 278 43095-101 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Harris, DL & Joyce, NC (2007) Protein tyrosine phosphatase, PTP1B, expression and activity in rat corneal endothelial cells. Mol. Vis. 13 785-96 PubMed GONUTS page
↑ Guan, KL et al. (1990) Cloning and expression of a protein-tyrosine-phosphatase. Proc. Natl. Acad. Sci. U.S.A. 87 1501-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Ahmad, F & Goldstein, BJ (1995) Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissue. Biochim. Biophys. Acta 1248 57-69 PubMed GONUTS page
↑ Hirata, AE et al. (2003) Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Life Sci. 73 1369-81 PubMed GONUTS page

[PMID:18583343-1] 1.0 ^1.1 Arachiche, A et al. (2008) Localization of PTP-1B, SHP-2, and Src exclusively in rat brain mitochondria and functional consequences. J. Biol. Chem. 283 24406-11 PubMed GONUTS page

[PMID:17897622-2] Shi, K et al. (2007) Membrane localization of protein-tyrosine phosphatase 1B is essential for its activation of sterol regulatory element-binding protein-1 gene expression. Biochem. Biophys. Res. Commun. 363 626-32 PubMed GONUTS page

[PMID:12941932-3] Shimizu, S et al. (2003) Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression. J. Biol. Chem. 278 43095-101 PubMed GONUTS page

[PMID:17563729-4] 4.0 ^4.1 ^4.2 Harris, DL & Joyce, NC (2007) Protein tyrosine phosphatase, PTP1B, expression and activity in rat corneal endothelial cells. Mol. Vis. 13 785-96 PubMed GONUTS page

[PMID:2154749-5] Guan, KL et al. (1990) Cloning and expression of a protein-tyrosine-phosphatase. Proc. Natl. Acad. Sci. U.S.A. 87 1501-5 PubMed GONUTS page

[PMID:7711057-6] 6.0 ^6.1 ^6.2 ^6.3 Ahmad, F & Goldstein, BJ (1995) Purification, identification and subcellular distribution of three predominant protein-tyrosine phosphatase enzymes in skeletal muscle tissue. Biochim. Biophys. Acta 1248 57-69 PubMed GONUTS page

[PMID:12850498-7] Hirata, AE et al. (2003) Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Life Sci. 73 1369-81 PubMed GONUTS page

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RAT:PTN1

Contents

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