RAT:NRX1A

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nrxn1
Protein Name(s)	Neurexin-1 Neurexin I-alpha Neurexin-1-alpha
External Links
UniProt	Q63372
EMBL	M96374
PIR	A40228
RefSeq	NP_068535.2
UniGene	Rn.54924
PDB	3BIW
PDBsum	3BIW
ProteinModelPortal	Q63372
SMR	Q63372
BioGrid	248813
MINT	MINT-1506888
PhosphoSite	Q63372
PRIDE	Q63372
GeneID	60391
KEGG	rno:60391
CTD	9378
RGD	628659
HOVERGEN	HBG052670
InParanoid	Q63372
KO	K07377
Reactome	REACT_198756
EvolutionaryTrace	Q63372
NextBio	612088
PRO	PR:Q63372
Proteomes	UP000002494
Genevestigator	Q63372
GO	GO:0030054 GO:0009986 GO:0016021 GO:0005886 GO:0042734 GO:0033130 GO:0005246 GO:0005509 GO:0050839 GO:0097109 GO:0030534 GO:0007155 GO:0097116 GO:0007612 GO:0097118 GO:0050885 GO:0007269 GO:2000463 GO:0051965 GO:0090129 GO:0051968 GO:0097119 GO:0097104 GO:0060134 GO:0051290 GO:2000821 GO:0007416 GO:0007268 GO:0006904
Gene3D	2.60.120.200
InterPro	IPR013320 IPR000742 IPR000152 IPR001791 IPR029824 IPR003585 IPR027789
PANTHER	PTHR10127:SF565
Pfam	PF02210 PF01034
SMART	SM00294 SM00181 SM00282
SUPFAM	SSF49899
PROSITE	PS00010 PS50026 PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048306	calcium-dependent cell-cell adhesion	PMID:9325340^[1]	ECO:0000021		UniProtKB:Q62765	P		Using detergent-solubilized neuroligins and secreted neurexin 1β-IgG fusion protein, we observed binding of these proteins to each other only in the presence of Ca2+ and in no other divalent cation tested. Figure 1, Figure 2	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C	part_of:(UBERON:0014554)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
involved_in	GO:2000821	regulation of grooming behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	F		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0090129	positive regulation of synapse maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	F		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C		Seeded From UniProt	complete
enables	GO:0033130	acetylcholine receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	F		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULB1	C		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	P		Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9CS84	F		Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[2]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[2]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:12796785^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:18093522^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0036057	slit diaphragm	PMID:21048075^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:22662246^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18755801^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:18334216^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006904	vesicle docking involved in exocytosis	PMID:22235116^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22235116^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037440	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-RNO-6794339 Reactome:R-RNO-6794334 Reactome:R-RNO-2426675	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0222	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nguyen, T & Südhof, TC (1997) Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J. Biol. Chem. 272 26032-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page
↑ Araç, D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56 992-1003 PubMed GONUTS page
↑ Saito, A et al. (2011) Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 R340-8 PubMed GONUTS page
↑ Shapiro-Reznik, M et al. (2012) Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock. PLoS ONE 7 e37894 PubMed GONUTS page
↑ Suckow, AT et al. (2008) Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149 6006-17 PubMed GONUTS page
↑ Koehnke, J et al. (2008) Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure 16 410-21 PubMed GONUTS page
↑ ^8.0 ^8.1 Mosedale, M et al. (2012) Neurexin-1α contributes to insulin-containing secretory granule docking. J. Biol. Chem. 287 6350-61 PubMed GONUTS page

[PMID:9325340-1] Nguyen, T & Südhof, TC (1997) Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J. Biol. Chem. 272 26032-9 PubMed GONUTS page

[PMID:12796785-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page

[PMID:18093522-3] Araç, D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56 992-1003 PubMed GONUTS page

[PMID:21048075-4] Saito, A et al. (2011) Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300 R340-8 PubMed GONUTS page

[PMID:22662246-5] Shapiro-Reznik, M et al. (2012) Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock. PLoS ONE 7 e37894 PubMed GONUTS page

[PMID:18755801-6] Suckow, AT et al. (2008) Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology 149 6006-17 PubMed GONUTS page

[PMID:18334216-7] Koehnke, J et al. (2008) Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure 16 410-21 PubMed GONUTS page

[PMID:22235116-8] 8.0 ^8.1 Mosedale, M et al. (2012) Neurexin-1α contributes to insulin-containing secretory granule docking. J. Biol. Chem. 287 6350-61 PubMed GONUTS page

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RAT:NRX1A

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