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RAT:NQO1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Nqo1 (synonyms: Nmor1) | |
| Protein Name(s) | NAD(P)H dehydrogenase [quinone] 1
Azoreductase DT-diaphorase DTD Menadione reductase NAD(P)H:quinone oxidoreductase 1 Phylloquinone reductase Quinone reductase 1 QR1 | |
| External Links | ||
| UniProt | P05982 | |
| EMBL | J02608 J02679 M36660 J02640 M31805 M31801 M31802 M31804 M33039 M33038 BC083542 X17464 | |
| PIR | A34162 | |
| RefSeq | NP_058696.2 | |
| UniGene | Rn.11234 | |
| PDB | 1QRD | |
| PDBsum | 1QRD | |
| ProteinModelPortal | P05982 | |
| SMR | P05982 | |
| IntAct | P05982 | |
| STRING | 10116.ENSRNOP00000017175 | |
| ChEMBL | CHEMBL3091269 | |
| iPTMnet | P05982 | |
| PhosphoSitePlus | P05982 | |
| World-2DPAGE | 0004:P05982 | |
| PaxDb | P05982 | |
| PRIDE | P05982 | |
| Ensembl | ENSRNOT00000017174 | |
| GeneID | 24314 | |
| KEGG | rno:24314 | |
| UCSC | RGD:2503 | |
| CTD | 1728 | |
| RGD | 2503 | |
| eggNOG | ENOG410IKWF COG2249 | |
| GeneTree | ENSGT00440000033410 | |
| HOGENOM | HOG000149970 | |
| HOVERGEN | HBG029104 | |
| InParanoid | P05982 | |
| KO | K00355 | |
| OMA | LFPIHHG | |
| OrthoDB | EOG091G183R | |
| PhylomeDB | P05982 | |
| TreeFam | TF300296 | |
| BRENDA | 1.6.5.2 | |
| Reactome | R-RNO-350562 | |
| EvolutionaryTrace | P05982 | |
| PRO | PR:P05982 | |
| Proteomes | UP000002494 | |
| Bgee | ENSRNOG00000012772 | |
| Genevisible | P05982 | |
| GO | GO:0005737 GO:0005829 GO:0030425 GO:0043025 GO:0042802 GO:0003955 GO:0004784 GO:0007568 GO:0070301 GO:0071248 GO:0043066 GO:0043086 GO:0043525 GO:0051602 GO:0032355 GO:0045471 GO:1904880 GO:1901698 GO:0007584 GO:0014070 GO:0006979 GO:0006801 | |
| Gene3D | 3.40.50.360 | |
| InterPro | IPR003680 IPR029039 | |
| Pfam | PF02525 | |
| SUPFAM | SSF52218 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1904880 |
response to hydrogen sulfide |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901698 |
response to nitrogen compound |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071248 |
cellular response to metal ion |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070301 |
cellular response to hydrogen peroxide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051602 |
response to electrical stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045471 |
response to ethanol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0014070 |
response to organic cyclic compound |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007584 |
response to nutrient |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007568 |
aging |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004784 |
superoxide dismutase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003955 |
NAD(P)H dehydrogenase (quinone) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000024521 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0009055 |
electron transfer activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000024521 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000024521 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003955 |
NAD(P)H dehydrogenase (quinone) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103187 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019430 |
removal of superoxide radicals |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004784 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022900 |
electron transport chain |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009055 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P15559 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P15559 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043086 |
negative regulation of catalytic activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64669 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64669 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003955 |
NAD(P)H dehydrogenase (quinone) activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q64669 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003955 |
NAD(P)H dehydrogenase (quinone) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Imamura, F et al. (2017) Hydrogen Sulfide Specifically Alters NAD(P)H Quinone Dehydrogenase 1 (NQO1) Olfactory Neurons in the Rat. Neuroscience 366 105-112 PubMed GONUTS page
- ↑ Sánchez-Rodríguez, R et al. (2017) Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress. Free Radic. Biol. Med. 102 87-99 PubMed GONUTS page
- ↑ Zhang, L et al. (2017) Activation of Nrf2/ARE signaling pathway attenuates lanthanum chloride induced injuries in primary rat astrocytes. Metallomics 9 1120-1131 PubMed GONUTS page
- ↑ Peng, S et al. (2017) Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage. Food Funct 8 997-1007 PubMed GONUTS page
- ↑ Hoque, KE et al. (2017) Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: Modulation by dopamine D1 and D2 receptor activation. Neuropharmacology 126 151-157 PubMed GONUTS page
- ↑ Yeligar, SM et al. (2010) Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression. J. Biol. Chem. 285 35359-73 PubMed GONUTS page
- ↑ 7.0 7.1 Kapinya, KJ et al. (2003) Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo. J. Neurochem. 84 1028-39 PubMed GONUTS page
- ↑ Kim, YH et al. (2012) Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase. Free Radic. Biol. Med. 52 880-8 PubMed GONUTS page
- ↑ 9.0 9.1 Stringer, JL et al. (2004) Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. J. Comp. Neurol. 471 289-97 PubMed GONUTS page
- ↑ Sanchez, RI et al. (2003) Induction of NAD(P)H quinone oxidoreductase and glutathione S-transferase activities in livers of female August-Copenhagen Irish rats treated chronically with estradiol: comparison with the Sprague-Dawley rat. J. Steroid Biochem. Mol. Biol. 87 199-206 PubMed GONUTS page
- ↑ 11.0 11.1 Halasy, K et al. (2017) Fine structure and synaptology of the nitrergic neurons in medial septum of the rat brain. Acta. Biol. Hung. 68 1-13 PubMed GONUTS page
- ↑ Kodavanti, PR et al. (2011) Toluene effects on oxidative stress in brain regions of young-adult, middle-age, and senescent Brown Norway rats. Toxicol. Appl. Pharmacol. 256 386-98 PubMed GONUTS page
- ↑ Krajka-Kuźniak, V et al. (2011) Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate. Br. J. Nutr. 105 816-26 PubMed GONUTS page
- ↑ Ungvari, Z et al. (2011) Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am. J. Physiol. Heart Circ. Physiol. 301 H363-72 PubMed GONUTS page
- ↑ Koike, E et al. (2002) cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Toxicol. Sci. 67 241-6 PubMed GONUTS page
- ↑ 16.0 16.1 Zhu, H et al. (2007) The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger. Cardiovasc. Toxicol. 7 202-11 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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- Rattus
- Rattus norvegicus
- GO:0019430 ! removal of superoxide radicals
- GO:1901698 ! response to nitrogen compound
- GO:0006979 ! response to oxidative stress
- GO:0007584 ! response to nutrient
- GO:0014070 ! response to organic cyclic compound
- GO:0032355 ! response to estradiol
- GO:0045471 ! response to ethanol
- GO:0051602 ! response to electrical stimulus
- GO:1904880 ! response to hydrogen sulfide
- Rodentia
