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RAT:NOX1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Nox1 (synonyms: Mox1, Noh1) | |
| Protein Name(s) | NADPH oxidase 1
NOX-1 Mitogenic oxidase 1 MOX-1 NADH/NADPH mitogenic oxidase subunit P65-MOX NOH-1 | |
| External Links | ||
| UniProt | Q9WV87 | |
| EMBL | AF152963 | |
| RefSeq | NP_446135.1 | |
| UniGene | Rn.220465 | |
| ProteinModelPortal | Q9WV87 | |
| SMR | Q9WV87 | |
| MINT | MINT-4998488 | |
| STRING | 10116.ENSRNOP00000065995 | |
| ChEMBL | CHEMBL1075231 | |
| PeroxiBase | 5408 | |
| iPTMnet | Q9WV87 | |
| PhosphoSitePlus | Q9WV87 | |
| PaxDb | Q9WV87 | |
| GeneID | 114243 | |
| KEGG | rno:114243 | |
| CTD | 27035 | |
| RGD | 620598 | |
| eggNOG | KOG0039 ENOG410XNZY | |
| HOVERGEN | HBG003760 | |
| InParanoid | Q9WV87 | |
| KO | K08008 | |
| PhylomeDB | Q9WV87 | |
| PRO | PR:Q9WV87 | |
| Proteomes | UP000002494 | |
| GO | GO:0030054 GO:0071438 GO:0043020 GO:0046872 GO:0016175 GO:2000379 GO:0048661 GO:0000302 GO:0007165 GO:0042554 | |
| InterPro | IPR000778 IPR013112 IPR017927 IPR013130 IPR013121 IPR029650 IPR017938 | |
| PANTHER | PTHR11972:SF110 | |
| Pfam | PF08022 PF01794 PF08030 | |
| PRINTS | PR00466 | |
| SUPFAM | SSF63380 | |
| PROSITE | PS51384 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016174 |
NAD(P)H oxidase activity |
ECO:0000315 |
F |
RAT NOX1 // Inhibition of NOX1 with 2-acetylphenothiazine resulted in a decrease of NADPH oxidase activity in cells (Fig. 2D) |
complete | |||||
|
involved_in |
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042554 |
superoxide anion generation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043020 |
NADPH oxidase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000302 |
response to reactive oxygen species |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0283531 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043020 |
NADPH oxidase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2681162 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042554 |
superoxide anion generation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1354184 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016175 |
superoxide-generating NADPH oxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1354184 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006952 |
defense response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0283531 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2139422 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016175 |
superoxide-generating NADPH oxidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000778 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042554 |
superoxide anion generation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000778 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016175 |
superoxide-generating NADPH oxidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0071438 |
invadopodium membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Blanca, AJ et al. (2017) l-Carnitine ameliorates the oxidative stress response to angiotensin II by modulating NADPH oxidase through a reduction in protein kinase c activity and NF-κB translocation to the nucleus. Food Chem 228 356-366 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Suh, YA et al. (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401 79-82 PubMed GONUTS page
- ↑ Plesková, M et al. (2006) Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB J. 20 139-41 PubMed GONUTS page
- ↑ Ambasta, RK et al. (2004) Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J. Biol. Chem. 279 45935-41 PubMed GONUTS page
- ↑ 5.0 5.1 Katsuyama, M et al. (2002) NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. J. Biol. Chem. 277 13438-42 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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