RAT:NISCH

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nisch
Protein Name(s)	Nischarin Imidazoline receptor 1 I-1 IR1 Imidazoline-1 receptor I1R
External Links
UniProt	Q4G017
EMBL	AABR03100261 BC098837
UniGene	Rn.96234
IntAct	Q4G017
STRING	10116.ENSRNOP00000061933
BindingDB	Q4G017
ChEMBL	CHEMBL5221
PhosphoSite	Q4G017
PaxDb	Q4G017
PRIDE	Q4G017
Ensembl	ENSRNOT00000036910
UCSC	RGD:1306950
RGD	1306950
eggNOG	COG4886
GeneTree	ENSGT00530000063625
HOGENOM	HOG000113789
HOVERGEN	HBG108189
InParanoid	Q4G017
OMA	TEFGFLM
OrthoDB	EOG70ZZMH
NextBio	13952063
Proteomes	UP000002494
Genevestigator	Q4G017
GO	GO:0005829 GO:0005769 GO:0016020 GO:0005886 GO:0055037 GO:0008227 GO:0035091 GO:0030036 GO:0006915 GO:0007186 GO:0006006 GO:0030336 GO:0048243 GO:0016601 GO:0008217 GO:0032228
Gene3D	3.30.1520.10
InterPro	IPR001611 IPR001683
Pfam	PF13855 PF00787
SMART	SM00312
SUPFAM	SSF64268
PROSITE	PS51450 PS50195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0048243	norepinephrine secretion	PMID:15028598^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032228	regulation of synaptic transmission, GABAergic	PMID:16467528^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:14975931^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:15028595^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000397128 UniProtKB:Q8N1F8	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002496044 PomBase:SPAC4A8.12c UniProtKB:Q8IB59 UniProtKB:Q8N1F8	C	Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TM9 ensembl:ENSMUSP00000022469	P	Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TM9 ensembl:ENSMUSP00000022469	P	Seeded From UniProt	complete
involved_in	GO:0016601	Rac protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TM9 ensembl:ENSMUSP00000022469	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TM9 ensembl:ENSMUSP00000022469	C	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TM9 ensembl:ENSMUSP00000022469	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y2I1 ensembl:ENSP00000418232	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y2I1 ensembl:ENSP00000418232	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y2I1 ensembl:ENSP00000418232	C	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037904	F	Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001683 InterPro:IPR036871 InterPro:IPR037904	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0055037	recycling endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0232	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Raasch, W et al. (2003) Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors. Ann. N. Y. Acad. Sci. 1009 270-3 PubMed GONUTS page
↑ Tanabe, M et al. (2006) Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons. J. Neurosci. 26 1795-802 PubMed GONUTS page
↑ Cao, C et al. (2004) Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 287 H150-6 PubMed GONUTS page
↑ Koletsky, RJ et al. (2003) The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. Ann. N. Y. Acad. Sci. 1009 251-61 PubMed GONUTS page
↑ ^5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15028598-1] Raasch, W et al. (2003) Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors. Ann. N. Y. Acad. Sci. 1009 270-3 PubMed GONUTS page

[PMID:16467528-2] Tanabe, M et al. (2006) Presynaptic I1-imidazoline receptors reduce GABAergic synaptic transmission in striatal medium spiny neurons. J. Neurosci. 26 1795-802 PubMed GONUTS page

[PMID:14975931-3] Cao, C et al. (2004) Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 287 H150-6 PubMed GONUTS page

[PMID:15028595-4] Koletsky, RJ et al. (2003) The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X. Ann. N. Y. Acad. Sci. 1009 251-61 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:NISCH

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