RAT:NAPEP

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Napepld
Protein Name(s)	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D N-acyl phosphatidylethanolamine phospholipase D NAPE-PLD NAPE-hydrolyzing phospholipase D
External Links
UniProt	Q769K2
EMBL	AB112351
RefSeq	NP_955413.1 XP_006235973.1 XP_008760861.1
UniGene	Rn.101892
ProteinModelPortal	Q769K2
STRING	10116.ENSRNOP00000015322
PhosphoSite	Q769K2
PaxDb	Q769K2
PRIDE	Q769K2
Ensembl	ENSRNOT00000015322
GeneID	296757
KEGG	rno:296757
CTD	222236
RGD	735197
eggNOG	COG2220
GeneTree	ENSGT00390000017990
HOGENOM	HOG000267495
HOVERGEN	HBG054649
InParanoid	Q769K2
KO	K13985
OMA	WGSWSVL
OrthoDB	EOG7Z95MB
PhylomeDB	Q769K2
Reactome	REACT_198271
NextBio	641757
Proteomes	UP000002494
Genevestigator	Q769K2
GO	GO:0070062 GO:0016020 GO:0070290 GO:0004620 GO:0008270 GO:0009395 GO:0006644
Gene3D	3.60.15.10
InterPro	IPR001279 IPR024884
PIRSF	PIRSF038896
SUPFAM	SSF56281

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0090336	positive regulation of brown fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BH82	P	Seeded From UniProt	complete
involved_in	GO:0070292	N-acylphosphatidylethanolamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BH82	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BH82	P	Seeded From UniProt	complete
involved_in	GO:0048874	host-mediated regulation of intestinal microbiota composition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BH82	P	Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BH82	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6IQ20	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q58CN9	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q58CN9	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q58CN9	C	Seeded From UniProt	complete
enables	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6IQ20	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6IQ20	F	Seeded From UniProt	complete
involved_in	GO:0070292	N-acylphosphatidylethanolamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6IQ20	P	Seeded From UniProt	complete
involved_in	GO:1903999	negative regulation of eating behavior	PMID:18434444^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043227	membrane-bounded organelle	PMID:10828091^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035900	response to isolation stress	PMID:23659592^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:10828091^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	PMID:14634025^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004620	phospholipase activity	PMID:14634025^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070292	N-acylphosphatidylethanolamine metabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001806046 SGD:S000006024	P	Seeded From UniProt	complete
involved_in	GO:0070291	N-acylethanolamine metabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2140885 PANTHER:PTN001806046 SGD:S000006024 WB:WBGene00021370 WB:WBGene00021371	P	Seeded From UniProt	complete
enables	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2140885 PANTHER:PTN001806046 WB:WBGene00021370 WB:WBGene00021371	F	Seeded From UniProt	complete
part_of	GO:0043227	membrane-bounded organelle	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001806046 RGD:735197	C	Seeded From UniProt	complete
involved_in	GO:0070292	N-acylphosphatidylethanolamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IQ20 ensembl:ENSP00000407112	P	Seeded From UniProt	complete
enables	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IQ20 ensembl:ENSP00000407112	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IQ20 ensembl:ENSP00000407112	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IQ20 ensembl:ENSP00000407112	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IQ20 ensembl:ENSP00000407112	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IQ20 ensembl:ENSP00000407112	C	Seeded From UniProt	complete
involved_in	GO:0090336	positive regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	P	Seeded From UniProt	complete
involved_in	GO:0070292	N-acylphosphatidylethanolamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	P	Seeded From UniProt	complete
involved_in	GO:0070291	N-acylethanolamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	P	Seeded From UniProt	complete
enables	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	F	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	P	Seeded From UniProt	complete
involved_in	GO:0048874	host-mediated regulation of intestinal microbiota composition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	P	Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BH82 ensembl:ENSMUSP00000110872	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024884	F	Seeded From UniProt	complete
enables	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024884	F	Seeded From UniProt	complete
enables	GO:0102200	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.54	F	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0009395	phospholipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0595	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0178	C	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fu, J et al. (2008) Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 R45-50 PubMed GONUTS page
↑ ^2.0 ^2.1 Moesgaard, B et al. (2000) Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain. A (31)P NMR and enzyme activity study. J. Lipid Res. 41 985-90 PubMed GONUTS page
↑ Bari, M et al. (2013) In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. FEBS J. 280 3376-88 PubMed GONUTS page
↑ ^4.0 ^4.1 Okamoto, Y et al. (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. J. Biol. Chem. 279 5298-305 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18434444-1] Fu, J et al. (2008) Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 R45-50 PubMed GONUTS page

[PMID:10828091-2] 2.0 ^2.1 Moesgaard, B et al. (2000) Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain. A (31)P NMR and enzyme activity study. J. Lipid Res. 41 985-90 PubMed GONUTS page

[PMID:23659592-3] Bari, M et al. (2013) In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. FEBS J. 280 3376-88 PubMed GONUTS page

[PMID:14634025-4] 4.0 ^4.1 Okamoto, Y et al. (2004) Molecular characterization of a phospholipase D generating anandamide and its congeners. J. Biol. Chem. 279 5298-305 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

RAT:NAPEP

Contents

Annotations

Notes

References

c

e

g

h

i

l

m

n

o

p

r

s

t

v

z

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools