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RAT:MYP0

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Mpz (synonyms: P0)
Protein Name(s) Myelin protein P0

Myelin peripheral protein MPP Myelin protein zero

External Links
UniProt P06907
EMBL K03242
PIR JQ0622
RefSeq NP_058723.1
UniGene Rn.8997
PDB 1NEU
PDBsum 1NEU
ProteinModelPortal P06907
SMR P06907
STRING 10116.ENSRNOP00000004279
PhosphoSite P06907
PaxDb P06907
Ensembl ENSRNOT00000004279
GeneID 24564
KEGG rno:24564
UCSC RGD:3109
CTD 4359
RGD 3109
eggNOG NOG47065
GeneTree ENSGT00640000091161
HOGENOM HOG000232144
HOVERGEN HBG096384
InParanoid P06907
KO K06770
OMA GDPQWKD
OrthoDB EOG7G1V80
PhylomeDB P06907
TreeFam TF331728
EvolutionaryTrace P06907
NextBio 603692
PRO PR:P06907
Proteomes UP000002494
Genevestigator P06907
GO GO:0016021
GO:0005886
GO:0045217
Gene3D 2.60.40.10
InterPro IPR007110
IPR013783
IPR013106
IPR003596
IPR019566
IPR019738
IPR000920
IPR029869
PANTHER PTHR13869
PTHR13869:SF7
Pfam PF10570
PF07686
PRINTS PR00213
SMART SM00406
PROSITE PS50835
PS00568

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005886

plasma membrane

PMID:10212299[1]

ECO:0000315

C

Figure 4.

complete
CACAO 9640

involved_in

GO:0098743

cell aggregation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25189

P

Seeded From UniProt

complete

involved_in

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25189

P

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P25189

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10212299[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:20552241[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:16788992[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

PMID:8789946[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:16788992[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0098743

cell aggregation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P25189
ensembl:ENSP00000432943

P

Seeded From UniProt

complete

involved_in

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P25189
ensembl:ENSP00000432943

P

Seeded From UniProt

complete

involved_in

GO:0042552

myelination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P25189
ensembl:ENSP00000432943

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P25189
ensembl:ENSP00000432943

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029869

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000920

C

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR029869

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 D'Urso, D et al. (1999) Peripheral myelin protein 22 and protein zero: a novel association in peripheral nervous system myelin. J. Neurosci. 19 3396-403 PubMed GONUTS page
  2. Lei, L et al. (2010) Mpz gene suppression by shRNA increases Schwann cell apoptosis in vitro. Neurol. Sci. 31 603-8 PubMed GONUTS page
  3. 3.0 3.1 Kidd, GJ et al. (2006) A dual tyrosine-leucine motif mediates myelin protein P0 targeting in MDCK cells. Glia 54 135-45 PubMed GONUTS page
  4. Cheng, L & Mudge, AW (1996) Cultured Schwann cells constitutively express the myelin protein P0. Neuron 16 309-19 PubMed GONUTS page