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PMID:8789946
| Citation |
Cheng, L and Mudge, AW (1996) Cultured Schwann cells constitutively express the myelin protein P0. Neuron 16:309-19 |
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| Abstract |
It is widely thought that mammalian Schwann cells do not express Po, the major glycoprotein in peripheral myelin, unless they are induced to do so by axonal signals that can be mimicked by agents that trigger cAMP signaling pathways. In contrast, we find that cultured Schwann cells make large amounts of Po without the addition of any axonal-like signal, provided they have not been exposed to serum during the culture process. We also report that glial growth factor/neuregulin inhibits this constitutive Po expression. Myelin basic protein is regulated in a similar way. We suggest that expression of Po by Schwann cells before the onset of myelination may be prevented by inhibitory signals within the nerve, rather than by the absence of a positive signal from axons. |
| Links | |
| Keywords |
Animals; Axons/physiology; Cell Division; Cells, Cultured; Fibroblast Growth Factor 2/pharmacology; Glia Maturation Factor; Myelin P0 Protein/antagonists & inhibitors; Myelin P0 Protein/metabolism; Nerve Tissue Proteins/pharmacology; Osmolar Concentration; Rats; Schwann Cells/cytology; Schwann Cells/metabolism; Signal Transduction |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005791: rough endoplasmic reticulum |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
See also
References
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