RAT:LIPL

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Lpl
Protein Name(s)	Lipoprotein lipase LPL
External Links
UniProt	Q06000
EMBL	L03294 BC081836
PIR	JH0790
RefSeq	NP_036730.1
UniGene	Rn.3834
ProteinModelPortal	Q06000
STRING	10116.ENSRNOP00000016543
BindingDB	Q06000
ChEMBL	CHEMBL5906
PaxDb	Q06000
PRIDE	Q06000
Ensembl	ENSRNOT00000016543
GeneID	24539
KEGG	rno:24539
UCSC	RGD:3017
CTD	4023
RGD	3017
eggNOG	NOG40923
GeneTree	ENSGT00760000119069
HOGENOM	HOG000038553
HOVERGEN	HBG002259
InParanoid	Q06000
KO	K01059
OMA	ESVANCH
OrthoDB	EOG757CX5
PhylomeDB	Q06000
TreeFam	TF324997
BRENDA	3.1.1.34
Reactome	REACT_199015 REACT_250929 REACT_260360
NextBio	603620
PRO	PR:Q06000
Proteomes	UP000002494
Genevestigator	Q06000
GO	GO:0031225 GO:0009986 GO:0042627 GO:0031012 GO:0070062 GO:0005886 GO:0034361 GO:0008201 GO:0004465 GO:0017129 GO:0016042 GO:0010886 GO:0010744 GO:0010890 GO:0009409 GO:0042493 GO:0019432 GO:0019433 GO:0070328
Gene3D	2.60.60.20 3.40.50.1820
InterPro	IPR029058 IPR016272 IPR008976 IPR013818 IPR002330 IPR001024 IPR000734
PANTHER	PTHR11610 PTHR11610:SF3
Pfam	PF00151 PF01477
PIRSF	PIRSF000865
PRINTS	PR00822 PR00821
SMART	SM00308
SUPFAM	SSF49723 SSF53474
TIGRFAMs	TIGR03230
PROSITE	PS00120 PS50095

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004465	lipoprotein lipase activity	PMID:21569266^[1]	ECO:0000314			F	Figure 3	complete CACAO 3561
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	P	Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	F	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	F	Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	C	Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06858	P	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:21569266^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1900077	negative regulation of cellular response to insulin stimulus	PMID:25931001^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:11016888^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019432	triglyceride biosynthetic process	PMID:11788374^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017129	triglyceride binding	PMID:12551943^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	PMID:12551943^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:18722549^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12551943^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:12551943^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	PMID:11788374^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
enables	GO:0071813	lipoprotein particle binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
involved_in	GO:0055096	low-density lipoprotein particle mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
enables	GO:0043395	heparan sulfate proteoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
involved_in	GO:0042632	cholesterol homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
involved_in	GO:0034372	very-low-density lipoprotein particle remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
involved_in	GO:0034371	chylomicron remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
enables	GO:0034185	apolipoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
involved_in	GO:0010886	positive regulation of cholesterol storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06858 ensembl:ENSP00000309757	F	Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:1904209	positive regulation of chemokine (C-C motif) ligand 2 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:0031670	cellular response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:0019433	triglyceride catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
involved_in	GO:0010744	positive regulation of macrophage derived foam cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	C	Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	C	Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	F	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11152 ensembl:ENSMUSP00000015712	F	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002330	F	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002330 InterPro:IPR016272 InterPro:IPR033906	P	Seeded From UniProt	complete
enables	GO:0052689	carboxylic ester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000734 InterPro:IPR016272	F	Seeded From UniProt	complete
enables	GO:0004465	lipoprotein lipase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.1.34	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C	Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0850	C	Seeded From UniProt	complete
part_of	GO:0042627	chylomicron	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0162	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Alberdi, G et al. (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8 29 PubMed GONUTS page
↑ Jan, M & Medh, JD (2015) ShRNA-mediated gene silencing of lipoprotein lipase improves insulin sensitivity in L6 skeletal muscle cells. Biochem. Biophys. Res. Commun. 462 33-7 PubMed GONUTS page
↑ Scribner, KA et al. (2000) Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metab. Clin. Exp. 49 1106-10 PubMed GONUTS page
↑ ^4.0 ^4.1 Picard, F et al. (2002) Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Am. J. Physiol. Endocrinol. Metab. 282 E412-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Wu, G et al. (2003) The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme. J. Biol. Chem. 278 11925-30 PubMed GONUTS page
↑ Cheng, Y & Hauton, D (2008) Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase. Biochim. Biophys. Acta 1781 618-26 PubMed GONUTS page

[PMID:21569266-1] 1.0 ^1.1 Alberdi, G et al. (2011) Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr Metab (Lond) 8 29 PubMed GONUTS page

[PMID:25931001-2] Jan, M & Medh, JD (2015) ShRNA-mediated gene silencing of lipoprotein lipase improves insulin sensitivity in L6 skeletal muscle cells. Biochem. Biophys. Res. Commun. 462 33-7 PubMed GONUTS page

[PMID:11016888-3] Scribner, KA et al. (2000) Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metab. Clin. Exp. 49 1106-10 PubMed GONUTS page

[PMID:11788374-4] 4.0 ^4.1 Picard, F et al. (2002) Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Am. J. Physiol. Endocrinol. Metab. 282 E412-8 PubMed GONUTS page

[PMID:12551943-5] 5.0 ^5.1 ^5.2 ^5.3 Wu, G et al. (2003) The distribution of lipoprotein lipase in rat adipose tissue. Changes with nutritional state engage the extracellular enzyme. J. Biol. Chem. 278 11925-30 PubMed GONUTS page

[PMID:18722549-6] Cheng, Y & Hauton, D (2008) Cold acclimation induces physiological cardiac hypertrophy and increases assimilation of triacylglycerol metabolism through lipoprotein lipase. Biochim. Biophys. Acta 1781 618-26 PubMed GONUTS page

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RAT:LIPL

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Annotations

Notes

References

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