RAT:KPYM

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pkm (synonyms: Pkm2, Pykm)
Protein Name(s)	Pyruvate kinase PKM Pyruvate kinase muscle isozyme
External Links
UniProt	P11980
EMBL	M24359 M24359 M14377 X15800
PIR	A26186 B26186
RefSeq	NP_445749.1
UniGene	Rn.1556
ProteinModelPortal	P11980
SMR	P11980
BioGrid	247659
IntAct	P11980
BindingDB	P11980
ChEMBL	CHEMBL4994
MoonProt	P11980
PhosphoSite	P11980
World-2DPAGE	0004:P11980
PaxDb	P11980
PRIDE	P11980
Ensembl	ENSRNOT00000015332
GeneID	25630
KEGG	rno:25630
UCSC	RGD:3337
CTD	5315
RGD	3337
eggNOG	COG0469
GeneTree	ENSGT00390000008859
HOGENOM	HOG000021559
HOVERGEN	HBG000941
InParanoid	P11980
KO	K00873
OMA	IELCRRN
OrthoDB	EOG78M01Q
PhylomeDB	P11980
TreeFam	TF300390
Reactome	REACT_225694
SABIO-RK	P11980
UniPathway	UPA00109
NextBio	607431
Proteomes	UP000002494
Genevestigator	P11980
GO	GO:0005737 GO:0005634 GO:0043531 GO:0005524 GO:0000287 GO:0030955 GO:0004743 GO:0006754 GO:0006006 GO:0006096 GO:0001889 GO:0031100 GO:0042866 GO:0009629 GO:0001666 GO:0032868 GO:0014870 GO:0007584 GO:0010033 GO:0043403
Gene3D	2.40.33.10 3.20.20.60 3.40.1380.20
InterPro	IPR001697 IPR015813 IPR011037 IPR015794 IPR018209 IPR015793 IPR015795 IPR015806
PANTHER	PTHR11817
Pfam	PF00224 PF02887
PRINTS	PR01050
SUPFAM	SSF50800 SSF51621 SSF52935
TIGRFAMs	TIGR01064
PROSITE	PS00110

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14618	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:1883388^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:1883388^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:1902912	pyruvate kinase complex	PMID:1883388^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:1883388^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:1883388^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070324	thyroid hormone binding	PMID:1883388^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043531	ADP binding	PMID:7040662^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	PMID:145474^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042866	pyruvate biosynthetic process	PMID:4273555^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:7929251^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	PMID:4005043^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014870	response to muscle inactivity	PMID:6331066^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:6537126^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009629	response to gravity	PMID:12165359^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:7929251^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006754	ATP biosynthetic process	PMID:4273555^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:8255543^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:4273555^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:7929251^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:8255543^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:4273555^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:7327170^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:3696161^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000212861 RGD:3336	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10803 EcoGene:EG10804 MGI:MGI:97591 PANTHER:PTN000212670 RGD:3336 RGD:3337 SGD:S000000036 UniProtKB:Q2RAK2	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000212670 SGD:S000000036 UniProtKB:P14618	C	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10803 EcoGene:EG10804 MGI:MGI:97591 MGI:MGI:97604 PANTHER:PTN000212670 PomBase:SPAC4H3.10c RGD:3336 RGD:3337 SGD:S000000036 SGD:S000005874 TAIR:locus:2033760 TAIR:locus:2084583 TAIR:locus:2176912 UniProtKB:C6KTA4 UniProtKB:P14618 UniProtKB:P30613 UniProtKB:Q2RAK2	F	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	P	Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	C	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14618 ensembl:ENSP00000320171	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5Z9 ensembl:ENSP00000320171	C	Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015813	F	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793 InterPro:IPR015806 InterPro:IPR018209	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793 InterPro:IPR015806 InterPro:IPR018209	P	Seeded From UniProt	complete
enables	GO:0030955	potassium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001697 InterPro:IPR015793	F	Seeded From UniProt	complete
enables	GO:0004743	pyruvate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.40	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Parkison, C et al. (1991) The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Biochem. Biophys. Res. Commun. 179 668-74 PubMed GONUTS page
↑ Hampton, A et al. (1982) Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 5. Interactions of adenosine 5'-triphosphate derivatives with rat pyruvate kinases, Escherichia coli thymidine kinase, and yeast and rat hexokinases. J. Med. Chem. 25 386-92 PubMed GONUTS page
↑ Wagner, KR et al. (1977) Developmental patterns of glycolytic enzymes in regenerating skeletal muscle after autogenous free grafting. J. Neurol. Sci. 34 373-90 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gunn, JM & Taylor, CB (1973) Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Biochem. J. 136 455-65 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kashiwaya, Y et al. (1994) Control of glucose utilization in working perfused rat heart. J. Biol. Chem. 269 25502-14 PubMed GONUTS page
↑ Chatzipanagiotou, S et al. (1985) Alteration in the capacities as well as in the zonal and cellular distributions of pyruvate kinase L and M2 in regenerating rat liver. Biol. Chem. Hoppe-Seyler 366 271-80 PubMed GONUTS page
↑ Vereb, G et al. (1984) Effect of immobilization on some glycolytic enzymes of skeletal muscle. Acta Physiol Hung 63 55-61 PubMed GONUTS page
↑ Sawicka, TJ et al. () Metabolic adaptation of muscles to exercise, vibration and raised temperature under the influence of cernitins. Acta Physiol Pol 35 141-50 PubMed GONUTS page
↑ Stein, T et al. (2002) Energy metabolism pathways in rat muscle under conditions of simulated microgravity. J. Nutr. Biochem. 13 471 PubMed GONUTS page
↑ ^10.0 ^10.1 Ratnakumari, L & Murthy, CR (1993) Response of rat cerebral glycolytic enzymes to hyperammonemic states. Neurosci. Lett. 161 37-40 PubMed GONUTS page
↑ Wu, SW et al. (1981) Biosynthesis of pyruvate kinase isozymes in rat liver. Eur. J. Biochem. 121 59-63 PubMed GONUTS page
↑ Webster, KA (1987) Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells. Mol. Cell. Biochem. 77 19-28 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1883388-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Parkison, C et al. (1991) The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Biochem. Biophys. Res. Commun. 179 668-74 PubMed GONUTS page

[PMID:7040662-2] Hampton, A et al. (1982) Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 5. Interactions of adenosine 5'-triphosphate derivatives with rat pyruvate kinases, Escherichia coli thymidine kinase, and yeast and rat hexokinases. J. Med. Chem. 25 386-92 PubMed GONUTS page

[PMID:145474-3] Wagner, KR et al. (1977) Developmental patterns of glycolytic enzymes in regenerating skeletal muscle after autogenous free grafting. J. Neurol. Sci. 34 373-90 PubMed GONUTS page

[PMID:4273555-4] 4.0 ^4.1 ^4.2 ^4.3 Gunn, JM & Taylor, CB (1973) Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Biochem. J. 136 455-65 PubMed GONUTS page

[PMID:7929251-5] 5.0 ^5.1 ^5.2 Kashiwaya, Y et al. (1994) Control of glucose utilization in working perfused rat heart. J. Biol. Chem. 269 25502-14 PubMed GONUTS page

[PMID:4005043-6] Chatzipanagiotou, S et al. (1985) Alteration in the capacities as well as in the zonal and cellular distributions of pyruvate kinase L and M2 in regenerating rat liver. Biol. Chem. Hoppe-Seyler 366 271-80 PubMed GONUTS page

[PMID:6331066-7] Vereb, G et al. (1984) Effect of immobilization on some glycolytic enzymes of skeletal muscle. Acta Physiol Hung 63 55-61 PubMed GONUTS page

[PMID:6537126-8] Sawicka, TJ et al. () Metabolic adaptation of muscles to exercise, vibration and raised temperature under the influence of cernitins. Acta Physiol Pol 35 141-50 PubMed GONUTS page

[PMID:12165359-9] Stein, T et al. (2002) Energy metabolism pathways in rat muscle under conditions of simulated microgravity. J. Nutr. Biochem. 13 471 PubMed GONUTS page

[PMID:8255543-10] 10.0 ^10.1 Ratnakumari, L & Murthy, CR (1993) Response of rat cerebral glycolytic enzymes to hyperammonemic states. Neurosci. Lett. 161 37-40 PubMed GONUTS page

[PMID:7327170-11] Wu, SW et al. (1981) Biosynthesis of pyruvate kinase isozymes in rat liver. Eur. J. Biochem. 121 59-63 PubMed GONUTS page

[PMID:3696161-12] Webster, KA (1987) Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells. Mol. Cell. Biochem. 77 19-28 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:KPYM

Contents

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