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RAT:IRS1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Irs1 (synonyms: Irs-1) | |
| Protein Name(s) | Insulin receptor substrate 1
IRS-1 pp185 | |
| External Links | ||
| UniProt | P35570 | |
| EMBL | X58375 | |
| PIR | S16948 | |
| RefSeq | NP_037101.1 | |
| UniGene | Rn.10476 | |
| ProteinModelPortal | P35570 | |
| SMR | P35570 | |
| BioGrid | 247500 | |
| DIP | DIP-664N | |
| IntAct | P35570 | |
| MINT | MINT-259238 | |
| STRING | 10116.ENSRNOP00000019579 | |
| BindingDB | P35570 | |
| ChEMBL | CHEMBL1163110 | |
| PhosphoSite | P35570 | |
| PaxDb | P35570 | |
| PRIDE | P35570 | |
| GeneID | 25467 | |
| KEGG | rno:25467 | |
| UCSC | RGD:2922 | |
| CTD | 3667 | |
| RGD | 2922 | |
| eggNOG | NOG81285 | |
| HOGENOM | HOG000113103 | |
| HOVERGEN | HBG000542 | |
| InParanoid | P35570 | |
| KO | K16172 | |
| PhylomeDB | P35570 | |
| Reactome | REACT_288944 REACT_314415 | |
| NextBio | 606757 | |
| PRO | PR:P35570 | |
| Proteomes | UP000002494 | |
| Genevisible | P35570 | |
| GO | GO:0005737 GO:0005829 GO:0005899 GO:0043231 GO:0005634 GO:0005886 GO:0005158 GO:0005159 GO:0043548 GO:0019904 GO:0019901 GO:0005080 GO:0042169 GO:0004871 GO:0005068 GO:0008286 GO:0048009 GO:0046627 GO:0046676 GO:0090275 GO:0070094 GO:0046628 GO:0043552 GO:0042327 GO:0051291 GO:0031000 GO:0043434 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR002404 IPR011993 IPR001849 | |
| Pfam | PF02174 PF00169 | |
| PRINTS | PR00628 | |
| SMART | SM00233 SM00310 | |
| PROSITE | PS51064 PS50003 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005829 |
cytosol |
ECO:0000314 |
C |
Source: RGD |
Missing: reference | |||||
| GO:0005010 |
insulin-like growth factor receptor activity |
ECO:0000315 |
F |
Source: RGD |
Missing: reference | |||||
| GO:0051291 |
protein heterooligomerization |
ECO:0000314 |
P |
Source: RGD |
Missing: reference | |||||
|
involved_in |
GO:0090275 |
negative regulation of somatostatin secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070094 |
positive regulation of glucagon secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046676 |
negative regulation of insulin secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042327 |
positive regulation of phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005899 |
insulin receptor complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005080 |
protein kinase C binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005068 |
transmembrane receptor protein tyrosine kinase adaptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043434 |
response to peptide hormone |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042169 |
SH2 domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005159 |
insulin-like growth factor receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005158 |
insulin receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990416 |
cellular response to brain-derived neurotrophic factor stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904385 |
cellular response to angiotensin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071478 |
cellular response to radiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051291 |
protein heterooligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:3329 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031000 |
response to caffeine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031000 |
response to caffeine |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:619758 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014823 |
response to activity |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007568 |
aging |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007568 |
aging |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005159 |
insulin-like growth factor receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
RGD:2869 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005158 |
insulin receptor binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109334 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024248 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109334 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024248 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005158 |
insulin receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024248 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005158 |
insulin receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-RNO-1168854 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Araujo, EP et al. (2002) Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion. FEBS Lett. 531 437-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Waraich, RS et al. (2008) Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. J. Biol. Chem. 283 11226-33 PubMed GONUTS page
- ↑ 3.0 3.1 Moeschel, K et al. (2004) Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J. Biol. Chem. 279 25157-63 PubMed GONUTS page
- ↑ Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
- ↑ 5.0 5.1 Backer, JM et al. (1992) Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11 3469-79 PubMed GONUTS page
- ↑ Algenstaedt, P et al. (1997) Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J. Biol. Chem. 272 23696-702 PubMed GONUTS page
- ↑ Skolnik, EY et al. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J. 12 1929-36 PubMed GONUTS page
- ↑ Tong, L et al. (2008) Interleukin-1 beta impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol. Aging 29 1380-93 PubMed GONUTS page
- ↑ Du, J et al. (1996) G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptor. Biochem. Biophys. Res. Commun. 218 934-9 PubMed GONUTS page
- ↑ Schnoke, M & Midura, RJ (2007) Pulsed electromagnetic fields rapidly modulate intracellular signaling events in osteoblastic cells: comparison to parathyroid hormone and insulin. J. Orthop. Res. 25 933-40 PubMed GONUTS page
- ↑ 11.0 11.1 Hayashi, K et al. (2004) Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells. J. Biol. Chem. 279 40807-18 PubMed GONUTS page
- ↑ 12.0 12.1 Khamzina, L et al. (2003) Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Gastroenterology 125 572-85 PubMed GONUTS page
- ↑ 13.0 13.1 Hirata, AE et al. (2003) Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Life Sci. 73 1369-81 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Villar, M et al. (2006) Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes. Biochim. Biophys. Acta 1763 197-206 PubMed GONUTS page
- ↑ Egawa, T et al. (2011) Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle. J. Appl. Physiol. 111 1629-36 PubMed GONUTS page
- ↑ Tan, Y et al. (2012) Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation. Toxicol. Lett. 214 279-87 PubMed GONUTS page
- ↑ Johansen, T et al. (2005) Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling. Growth Horm. IGF Res. 15 55-63 PubMed GONUTS page
- ↑ 18.0 18.1 Pasini, E et al. (2012) Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats. Exp. Gerontol. 47 23-8 PubMed GONUTS page
- ↑ Haddad, F & Adams, GR (2006) Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. J. Appl. Physiol. 100 1188-203 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
g
i
- GO:0005010 ! insulin-like growth factor receptor activity
- GO:0048009 ! insulin-like growth factor receptor signaling pathway
- GO:0005159 ! insulin-like growth factor receptor binding
- GO:0008286 ! insulin receptor signaling pathway
- GO:0005899 ! insulin receptor complex
- GO:0005158 ! insulin receptor binding
- GO:0043231 ! intracellular membrane-bounded organelle
- IRS comparison
n
o
p
- GO:0043548 ! phosphatidylinositol 3-kinase binding
- GO:0005886 ! plasma membrane
- GO:0042327 ! positive regulation of phosphorylation
- GO:0046628 ! positive regulation of insulin receptor signaling pathway
- GO:0070094 ! positive regulation of glucagon secretion
- GO:0019904 ! protein domain specific binding
- GO:0051291 ! protein heterooligomerization
- GO:0019901 ! protein kinase binding
- GO:0005080 ! protein kinase C binding
r
