RAT:HCN2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Hcn2
Protein Name(s)	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
External Links
UniProt	Q9JKA9
EMBL	AB164197 AF247451 AF155164
RefSeq	NP_446136.1
UniGene	Rn.162907
ProteinModelPortal	Q9JKA9
SMR	Q9JKA9
BioGrid	250321
STRING	10116.ENSRNOP00000011837
PhosphoSite	Q9JKA9
PaxDb	Q9JKA9
PRIDE	Q9JKA9
GeneID	114244
KEGG	rno:114244
UCSC	RGD:620689
CTD	610
RGD	620689
eggNOG	COG0664
HOGENOM	HOG000230717
HOVERGEN	HBG039489
InParanoid	Q9JKA9
KO	K04955
PhylomeDB	Q9JKA9
NextBio	618449
PRO	PR:Q9JKA9
Proteomes	UP000002494
Genevestigator	Q9JKA9
GO	GO:0030424 GO:0043198 GO:0005887 GO:0016020 GO:0043025 GO:0005886 GO:0045202 GO:0030552 GO:0005222 GO:0030165 GO:0032947 GO:0005272 GO:0005249 GO:0007568 GO:0007420 GO:0071320 GO:0045823 GO:0071805 GO:0042391 GO:0042493 GO:0009725
Gene3D	2.60.120.10
InterPro	IPR018490 IPR018488 IPR000595 IPR005821 IPR013621 IPR003938 IPR014710
Pfam	PF00027 PF00520 PF08412
PRINTS	PR01463
SMART	SM00100
SUPFAM	SSF51206
PROSITE	PS00888 PS50042

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006810	transport	PMID:22948144^[1]	ECO:0000314			P	Figure 4: agarose gel for HCN1 PCR indicating amplification from the cochlear inner and outer hair cell cDNA of predicted 397-bp product crossing intron (white arrows).	complete CACAO 10708
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UL51	P	Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UL51	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UL51	C	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UL51	F	Seeded From UniProt	complete
enables	GO:0005222	intracellular cAMP-activated cation channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UL51	F	Seeded From UniProt	complete
involved_in	GO:1904045	cellular response to aldosterone	PMID:17644563^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072718	response to cisplatin	PMID:19584356^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:17439493^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:22948144^[1]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1308941 RGD:620688	F	Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:17439493^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:18478257^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:19584356^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0036477	somatodendritic compartment	PMID:23324324^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0032947	protein-containing complex scaffold activity	PMID:15265006^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:23324324^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:18668683^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:15265006^[7]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621855 RGD:70554	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15265006^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:10488052^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:17572839^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:19587292^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:19409968^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19409968^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23324324^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005272	P	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F	Seeded From UniProt	complete
enables	GO:0005249	voltage-gated potassium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003938 InterPro:IPR005821	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
enables	GO:0030552	cAMP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0116	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0633	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0005267	potassium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	F	Seeded From UniProt	complete
involved_in	GO:0071805	potassium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0631	P	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P	Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0894	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ramakrishnan, NA et al. (2012) HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J. Biol. Chem. 287 37628-46 PubMed GONUTS page
↑ Muto, T et al. (2007) Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 293 H2710-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Yeh, J et al. (2009) Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Reprod Sci 16 986-94 PubMed GONUTS page
↑ ^4.0 ^4.1 Boyes, J et al. (2007) Functional presynaptic HCN channels in the rat globus pallidus. Eur. J. Neurosci. 25 2081-92 PubMed GONUTS page
↑ Budde, T et al. (2008) Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane. Pflugers Arch. 456 1061-73 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Dougherty, KA et al. (2013) Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. J. Neurophysiol. 109 1940-53 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kimura, K et al. (2004) Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction. Genes Cells 9 631-40 PubMed GONUTS page
↑ Buniel, M et al. (2008) Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. J. Comp. Neurol. 510 367-77 PubMed GONUTS page
↑ Pachucki, J et al. (1999) Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Circ. Res. 85 498-503 PubMed GONUTS page
↑ Huang, X et al. (2007) Age-related down-regulation of HCN channels in rat sinoatrial node. Basic Res. Cardiol. 102 429-35 PubMed GONUTS page
↑ Kanyshkova, T et al. (2009) Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J. Neurosci. 29 8847-57 PubMed GONUTS page
↑ ^12.0 ^12.1 Cho, HJ et al. (2009) Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine. Neuroscience 162 453-61 PubMed GONUTS page

[PMID:22948144-1] 1.0 ^1.1 Ramakrishnan, NA et al. (2012) HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J. Biol. Chem. 287 37628-46 PubMed GONUTS page

[PMID:17644563-2] Muto, T et al. (2007) Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 293 H2710-8 PubMed GONUTS page

[PMID:19584356-3] 3.0 ^3.1 Yeh, J et al. (2009) Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Reprod Sci 16 986-94 PubMed GONUTS page

[PMID:17439493-4] 4.0 ^4.1 Boyes, J et al. (2007) Functional presynaptic HCN channels in the rat globus pallidus. Eur. J. Neurosci. 25 2081-92 PubMed GONUTS page

[PMID:18478257-5] Budde, T et al. (2008) Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane. Pflugers Arch. 456 1061-73 PubMed GONUTS page

[PMID:23324324-6] 6.0 ^6.1 ^6.2 Dougherty, KA et al. (2013) Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus. J. Neurophysiol. 109 1940-53 PubMed GONUTS page

[PMID:15265006-7] 7.0 ^7.1 ^7.2 Kimura, K et al. (2004) Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction. Genes Cells 9 631-40 PubMed GONUTS page

[PMID:18668683-8] Buniel, M et al. (2008) Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body. J. Comp. Neurol. 510 367-77 PubMed GONUTS page

[PMID:10488052-9] Pachucki, J et al. (1999) Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Circ. Res. 85 498-503 PubMed GONUTS page

[PMID:17572839-10] Huang, X et al. (2007) Age-related down-regulation of HCN channels in rat sinoatrial node. Basic Res. Cardiol. 102 429-35 PubMed GONUTS page

[PMID:19587292-11] Kanyshkova, T et al. (2009) Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J. Neurosci. 29 8847-57 PubMed GONUTS page

[PMID:19409968-12] 12.0 ^12.1 Cho, HJ et al. (2009) Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine. Neuroscience 162 453-61 PubMed GONUTS page

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RAT:HCN2

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