RAT:HAP1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Hap1
Protein Name(s)	Huntingtin-associated protein 1 HAP-1
External Links
UniProt	P54256
EMBL	U38370 U38373
PIR	S67492 S67495
RefSeq	NP_077047.1 NP_817091.1
UniGene	Rn.37430
ProteinModelPortal	P54256
IntAct	P54256
MINT	MINT-421542
STRING	10116.ENSRNOP00000020603
PaxDb	P54256
PRIDE	P54256
GeneID	29430
KEGG	rno:29430
UCSC	RGD:68327
CTD	9001
RGD	68327
eggNOG	NOG246428
HOGENOM	HOG000230957
HOVERGEN	HBG031599
InParanoid	P54256
KO	K04647
PhylomeDB	P54256
NextBio	609148
PRO	PR:P54256
Proteomes	UP000002494
Genevestigator	P54256
GO	GO:0005776 GO:0043679 GO:0030054 GO:0005737 GO:0005856 GO:0030425 GO:0005769 GO:0005783 GO:0030426 GO:0005770 GO:0005764 GO:0005739 GO:0043005 GO:0005634 GO:0048471 GO:0008021 GO:0048403 GO:0042802 GO:0044325 GO:0019904 GO:0005102 GO:0008089 GO:0006914 GO:0030030 GO:0071363 GO:0045022 GO:0006887 GO:1902430 GO:0031175 GO:0048011 GO:0045742 GO:0090261 GO:0031587 GO:0010976 GO:0032901 GO:1902857 GO:0032230 GO:0015031 GO:0017157 GO:1902513 GO:0008090
InterPro	IPR006933
Pfam	PF04849

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1902857	positive regulation of non-motile cilium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35668	P		Seeded From UniProt	complete
involved_in	GO:1902513	regulation of organelle transport along microtubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35668	P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35668	P		Seeded From UniProt	complete
involved_in	GO:0017157	regulation of exocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35668	P		Seeded From UniProt	complete
enables	GO:0048403	brain-derived neurotrophic factor binding	PMID:21357693^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032901	positive regulation of neurotrophin production	PMID:21357693^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:22731248^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008090	retrograde axonal transport	PMID:22731248^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:22731248^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	PMID:20152113^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	PMID:20152113^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048403	brain-derived neurotrophic factor binding	PMID:19996106^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032901	positive regulation of neurotrophin production	PMID:19996106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:19996106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008090	retrograde axonal transport	PMID:19996106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:12873381^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:12873381^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	PMID:12890790^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099524	postsynaptic cytosol	PMID:9742138^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:9742138^[7]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:15310851^[8]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:15310851^[8]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:15310851^[8]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:15310851^[8]	ECO:0005644	immunoprecipitation evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	PMID:15310851^[8]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15310851^[8]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15310851^[8]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15310851^[8]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15310851^[8]	ECO:0005644	immunoprecipitation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15310851^[8]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:10924259^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:10924259^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	PMID:10924259^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:10924259^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:10924259^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:10924259^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:12873381^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2933	F		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:10924259^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12873381^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2933	F		Seeded From UniProt	complete
involved_in	GO:0098957	anterograde axonal transport of mitochondrion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1914345 PANTHER:PTN001813314	P		Seeded From UniProt	complete
involved_in	GO:0048311	mitochondrion distribution	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262872 PANTHER:PTN001039683	P		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261831 PANTHER:PTN000405662	P		Seeded From UniProt	complete
involved_in	GO:0047496	vesicle transport along microtubule	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261831 PANTHER:PTN001039683	P		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1918077 PANTHER:PTN001813314	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261831 PANTHER:PTN001039683	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1918077 PANTHER:PTN001813314 RGD:1307844 RGD:620915 RGD:68327	C		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261831 PANTHER:PTN001813314	P		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262872 PANTHER:PTN001039683	F		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001039683 UniProtKB:P54257	P		Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1261831 PANTHER:PTN001813314 RGD:68327	P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001039683 RGD:620915	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262872 PANTHER:PTN001039683 RGD:620915 UniProtKB:Q9UPV9	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001039683 RGD:620915 RGD:68327 UniProtKB:Q9UPV9	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001813314 RGD:620915 RGD:68327	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9798945^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54256	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9361024^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54256	F		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008090	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008090	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008089	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0098957	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9798945^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54256-1	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17166838^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:17166838^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090261	positive regulation of inclusion body assembly	PMID:9798945^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9798945^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54256-2	F		Seeded From UniProt	complete
involved_in	GO:0045022	early endosome to late endosome transport	PMID:12021262^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:12021262^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:12021262^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0970	P		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0268	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0023	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0259	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yang, M et al. (2011) Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J. Biol. Chem. 286 16272-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Yang, GZ et al. (2012) Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J. Neurochem. 122 1010-22 PubMed GONUTS page
↑ ^3.0 ^3.1 Twelvetrees, AE et al. (2010) Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron 65 53-65 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wu, LL et al. (2010) Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J. Biol. Chem. 285 5614-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Tang, TS et al. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39 227-39 PubMed GONUTS page
↑ Li, SH et al. (2003) Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J. Neurosci. 23 6956-64 PubMed GONUTS page
↑ ^7.0 ^7.1 Gutekunst, CA et al. (1998) The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. J. Neurosci. 18 7674-86 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Kittler, JT et al. (2004) Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc. Natl. Acad. Sci. U.S.A. 101 12736-41 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Li, SH et al. (2000) Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth. Mol. Cell. Neurosci. 16 168-83 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Li, SH et al. (1998) Association of HAP1 isoforms with a unique cytoplasmic structure. J. Neurochem. 71 2178-85 PubMed GONUTS page
↑ Engelender, S et al. (1997) Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum. Mol. Genet. 6 2205-12 PubMed GONUTS page
↑ ^13.0 ^13.1 Rong, J et al. (2007) 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. J. Biol. Chem. 282 4748-56 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Li, Y et al. (2002) Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J. Biol. Chem. 277 28212-21 PubMed GONUTS page

[PMID:21357693-1] 1.0 ^1.1 Yang, M et al. (2011) Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing. J. Biol. Chem. 286 16272-84 PubMed GONUTS page

[PMID:22731248-2] 2.0 ^2.1 ^2.2 Yang, GZ et al. (2012) Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons. J. Neurochem. 122 1010-22 PubMed GONUTS page

[PMID:20152113-3] 3.0 ^3.1 Twelvetrees, AE et al. (2010) Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron 65 53-65 PubMed GONUTS page

[PMID:19996106-4] 4.0 ^4.1 ^4.2 ^4.3 Wu, LL et al. (2010) Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. J. Biol. Chem. 285 5614-23 PubMed GONUTS page

[PMID:12873381-5] 5.0 ^5.1 ^5.2 ^5.3 Tang, TS et al. (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39 227-39 PubMed GONUTS page

[PMID:12890790-6] Li, SH et al. (2003) Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. J. Neurosci. 23 6956-64 PubMed GONUTS page

[PMID:9742138-7] 7.0 ^7.1 Gutekunst, CA et al. (1998) The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. J. Neurosci. 18 7674-86 PubMed GONUTS page

[PMID:15310851-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Kittler, JT et al. (2004) Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc. Natl. Acad. Sci. U.S.A. 101 12736-41 PubMed GONUTS page

[PMID:10924259-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Li, SH et al. (2000) Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth. Mol. Cell. Neurosci. 16 168-83 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9798945-11] 11.0 ^11.1 ^11.2 ^11.3 Li, SH et al. (1998) Association of HAP1 isoforms with a unique cytoplasmic structure. J. Neurochem. 71 2178-85 PubMed GONUTS page

[PMID:9361024-12] Engelender, S et al. (1997) Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. Hum. Mol. Genet. 6 2205-12 PubMed GONUTS page

[PMID:17166838-13] 13.0 ^13.1 Rong, J et al. (2007) 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. J. Biol. Chem. 282 4748-56 PubMed GONUTS page

[PMID:12021262-14] 14.0 ^14.1 ^14.2 Li, Y et al. (2002) Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. J. Biol. Chem. 277 28212-21 PubMed GONUTS page

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RAT:HAP1

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