RAT:GRIA3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Gria3 (synonyms: Glur3)
Protein Name(s)	Glutamate receptor 3 GluR-3 AMPA-selective glutamate receptor 3 GluR-C GluR-K3 Glutamate receptor ionotropic, AMPA 3 GluA3
External Links
UniProt	P19492
EMBL	M36420 X54656 M38062 M85036
PIR	C40170
RefSeq	NP_001106213.1 NP_116785.2
UniGene	Rn.74049
PDB	3DLN 3DP4 3LSW 3LSX 3M3F 3M3K 3O21 3P3W 3RT6 3RT8 4F1Y 4F22 4F29 4F2O 4F2Q 4F31 4F39 4F3B 4F3G
PDBsum	3DLN 3DP4 3LSW 3LSX 3M3F 3M3K 3O21 3P3W 3RT6 3RT8 4F1Y 4F22 4F29 4F2O 4F2Q 4F31 4F39 4F3B 4F3G
ProteinModelPortal	P19492
SMR	P19492
BioGrid	248251
DIP	DIP-30954N
IntAct	P19492
MINT	MINT-86220
STRING	10116.ENSRNOP00000010367
BindingDB	P19492
ChEMBL	CHEMBL2093871
GuidetoPHARMACOLOGY	446
PhosphoSite	P19492
PaxDb	P19492
PRIDE	P19492
GeneID	29628
KEGG	rno:29628
UCSC	RGD:70958
CTD	2892
RGD	70958
eggNOG	NOG316680
HOGENOM	HOG000234372
HOVERGEN	HBG051839
InParanoid	P19492
KO	K05199
PhylomeDB	P19492
EvolutionaryTrace	P19492
NextBio	609848
Proteomes	UP000002494
Genevestigator	P19492
GO	GO:0032281 GO:0032279 GO:0030054 GO:0030425 GO:0043198 GO:0043197 GO:0008328 GO:0043025 GO:0043204 GO:0014069 GO:0045211 GO:0043234 GO:0043083 GO:0043195 GO:0004971 GO:0005234 GO:0004970 GO:0030165 GO:0034220 GO:0035235 GO:0001919 GO:0060992 GO:0010226 GO:0035249
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR028082
Pfam	PF01094 PF00060 PF10613
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001540	amyloid-beta binding	PMID:20032460^[1]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P19491	F	occurs_in:(CL:0002608) occurs_at:(GO:0009897)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10027300^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EP80	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:11348590^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	PMID:19265014^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:10027300^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9EP80	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:10027300^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	PMID:15269270^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001919	regulation of receptor recycling	PMID:11348590^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:12761821^[6]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:16903873^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:16903873^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:16903873^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:16903873^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12761821^[6]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0060992	response to fungicide	PMID:19591855^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:15844209^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:12077196^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:17207780^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:12077196^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:15844209^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	PMID:17207780^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12077196^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032279	asymmetric synapse	PMID:12077196^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:15844209^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17207780^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:12077196^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	PMID:11834304^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	PMID:11834304^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032281	AMPA glutamate receptor complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95808 MGI:MGI:95809 MGI:MGI:95810 MGI:MGI:95811 PANTHER:PTN000438080 RGD:61862 RGD:61863 RGD:621531 RGD:70958	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004971	AMPA glutamate receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000438080 RGD:61862 RGD:61863 RGD:621531 RGD:70958 UniProtKB:P42261 UniProtKB:P42263 UniProtKB:P48058	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004970	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004970	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004971	P		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
part_of	GO:0008328	ionotropic glutamate receptor complex	PMID:11836517^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhao, WQ et al. (2010) Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. J. Biol. Chem. 285 7619-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Xia, J et al. (1999) Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22 179-87 PubMed GONUTS page
↑ ^3.0 ^3.1 Shi, S et al. (2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105 331-43 PubMed GONUTS page
↑ Schwenk, J et al. (2009) Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 323 1313-9 PubMed GONUTS page
↑ Du, J et al. (2004) Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. J. Neurosci. 24 6578-89 PubMed GONUTS page
↑ ^6.0 ^6.1 Moga, DE et al. (2003) Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus. J. Comp. Neurol. 462 15-28 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Feligioni, M et al. (2006) Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. J. Neurochem. 99 549-60 PubMed GONUTS page
↑ Nakatsu, Y et al. (2009) Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Toxicol. Appl. Pharmacol. 240 292-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lu, CR et al. (2005) Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. J. Comp. Neurol. 486 169-78 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Levy, RB & Aoki, C (2002) Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex. J. Neurosci. 22 5001-15 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Radley, JJ et al. (2007) Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Brain Res. 1134 87-94 PubMed GONUTS page
↑ ^12.0 ^12.1 Nishizaki, T & Matsumura, T (2002) The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. Brain Res. Mol. Brain Res. 98 130-4 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Madden, DR (2002) The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci. 3 91-101 PubMed GONUTS page

[PMID:20032460-1] Zhao, WQ et al. (2010) Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption. J. Biol. Chem. 285 7619-32 PubMed GONUTS page

[PMID:10027300-2] 2.0 ^2.1 ^2.2 Xia, J et al. (1999) Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22 179-87 PubMed GONUTS page

[PMID:11348590-3] 3.0 ^3.1 Shi, S et al. (2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105 331-43 PubMed GONUTS page

[PMID:19265014-4] Schwenk, J et al. (2009) Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 323 1313-9 PubMed GONUTS page

[PMID:15269270-5] Du, J et al. (2004) Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. J. Neurosci. 24 6578-89 PubMed GONUTS page

[PMID:12761821-6] 6.0 ^6.1 Moga, DE et al. (2003) Glutamate receptor subunit 3 (GluR3) immunoreactivity delineates a subpopulation of parvalbumin-containing interneurons in the rat hippocampus. J. Comp. Neurol. 462 15-28 PubMed GONUTS page

[PMID:16903873-7] 7.0 ^7.1 ^7.2 ^7.3 Feligioni, M et al. (2006) Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density. J. Neurochem. 99 549-60 PubMed GONUTS page

[PMID:19591855-8] Nakatsu, Y et al. (2009) Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Toxicol. Appl. Pharmacol. 240 292-8 PubMed GONUTS page

[PMID:15844209-9] 9.0 ^9.1 ^9.2 Lu, CR et al. (2005) Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. J. Comp. Neurol. 486 169-78 PubMed GONUTS page

[PMID:12077196-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Levy, RB & Aoki, C (2002) Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex. J. Neurosci. 22 5001-15 PubMed GONUTS page

[PMID:17207780-11] 11.0 ^11.1 ^11.2 Radley, JJ et al. (2007) Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Brain Res. 1134 87-94 PubMed GONUTS page

[PMID:11834304-12] 12.0 ^12.1 Nishizaki, T & Matsumura, T (2002) The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. Brain Res. Mol. Brain Res. 98 130-4 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11836517-14] Madden, DR (2002) The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci. 3 91-101 PubMed GONUTS page

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RAT:GRIA3

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