RAT:F262

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pfkfb2
Protein Name(s)	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6PF-2-K/Fru-2,6-P2ase 2 PFK/FBPase 2 6PF-2-K/Fru-2,6-P2ase heart-type isozyme RH2K 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
External Links
UniProt	Q9JJH5
EMBL	S67900 L27084 AB040530 AB040531 AB040532 AB040533
PIR	JC2037
RefSeq	NP_001029136.1 NP_001029137.1 NP_536725.2 XP_006249768.1 XP_006249769.1 XP_006249770.1 XP_006249771.1 XP_006249773.1
UniGene	Rn.44844
ProteinModelPortal	Q9JJH5
SMR	Q9JJH5
STRING	10116.ENSRNOP00000005729
PhosphoSite	Q9JJH5
PaxDb	Q9JJH5
PRIDE	Q9JJH5
Ensembl	ENSRNOT00000005729 ENSRNOT00000037679 ENSRNOT00000050354
GeneID	24640
KEGG	rno:24640
UCSC	RGD:3309
CTD	5208
RGD	3309
eggNOG	COG0406
GeneTree	ENSGT00390000018751
HOGENOM	HOG000181112
HOVERGEN	HBG005628
InParanoid	Q9JJH5
KO	K01103
OMA	HPRTIYL
OrthoDB	EOG7M3J03
PhylomeDB	Q9JJH5
TreeFam	TF313541
BRENDA	3.1.3.46
Reactome	REACT_225694
SABIO-RK	Q9JJH5
NextBio	603930
PRO	PR:Q9JJH5
Proteomes	UP000002494
ExpressionAtlas	Q9JJH5
Genevestigator	Q9JJH5
GO	GO:0005737 GO:0003873 GO:0005524 GO:0004331 GO:0019900 GO:0046835 GO:0016311 GO:0006003 GO:0006000 GO:0006007 GO:0006096 GO:0006089 GO:0033133 GO:0032024 GO:0006090 GO:0009749
Gene3D	3.40.50.1240 3.40.50.300
InterPro	IPR003094 IPR013079 IPR016260 IPR013078 IPR029033 IPR027417 IPR001345
PANTHER	PTHR10606
Pfam	PF01591 PF00300
PIRSF	PIRSF000709
PRINTS	PR00991
SMART	SM00855
SUPFAM	SSF52540 SSF53254
PROSITE	PS00175

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PMID:18039179^[1]	ECO:0000314			F	Figure 3.	complete CACAO 6308
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PMID:18039179^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60825	P	Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60825	F	Seeded From UniProt	complete
involved_in	GO:0033133	positive regulation of glucokinase activity	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:11522786^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:69130	F	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006090	pyruvate metabolic process	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006089	lactate metabolic process	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006007	glucose catabolic process	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16980436^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006003	fructose 2,6-bisphosphate metabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743282 RGD:619776 SGD:S000001369 SGD:S000005496 TAIR:locus:2007367 UniProtKB:P16118	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743282 TAIR:locus:2007367	C	Seeded From UniProt	complete
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107815 PANTHER:PTN000064403 RGD:3307 RGD:3309 RGD:3310 SGD:S000003691 TAIR:locus:2007367 UniProtKB:P16118	F	Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743282 RGD:3307 RGD:3310 SGD:S000001369 UniProtKB:O60825 UniProtKB:P16118 UniProtKB:Q16875 UniProtKB:Q16877	F	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004331	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004331	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004331	P	Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004331	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003873	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003873	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003873	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003873	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003873	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003873	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60825 ensembl:ENSP00000356047	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60825 ensembl:ENSP00000356047	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60825 ensembl:ENSP00000356047	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60825 ensembl:ENSP00000356047	C	Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O60825 ensembl:ENSP00000356047	F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001345 InterPro:IPR003094	F	Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013079	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003094 InterPro:IPR013079	F	Seeded From UniProt	complete
involved_in	GO:0006000	fructose metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013079	P	Seeded From UniProt	complete
involved_in	GO:0006003	fructose 2,6-bisphosphate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003094	P	Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.105	F	Seeded From UniProt	complete
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.46	F	Seeded From UniProt	complete
involved_in	GO:0006003	fructose 2,6-bisphosphate metabolic process	PMID:1652483^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	PMID:1652483^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003873	6-phosphofructo-2-kinase activity	PMID:1652483^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Arden, C et al. (2008) A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. Biochem. J. 411 41-51 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Baltrusch, S et al. (2006) Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells. Endocrinology 147 5768-76 PubMed GONUTS page
↑ Baltrusch, S et al. (2001) Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. J. Biol. Chem. 276 43915-23 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Darville, MI et al. (1991) A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Lett. 288 91-4 PubMed GONUTS page

[PMID:18039179-1] 1.0 ^1.1 Arden, C et al. (2008) A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. Biochem. J. 411 41-51 PubMed GONUTS page

[PMID:16980436-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Baltrusch, S et al. (2006) Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells. Endocrinology 147 5768-76 PubMed GONUTS page

[PMID:11522786-3] Baltrusch, S et al. (2001) Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. J. Biol. Chem. 276 43915-23 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1652483-5] 5.0 ^5.1 ^5.2 Darville, MI et al. (1991) A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Lett. 288 91-4 PubMed GONUTS page

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RAT:F262

Contents

Annotations

Notes

References

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