RAT:CFTR

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cftr (synonyms: Abcc7)
Protein Name(s)	Cystic fibrosis transmembrane conductance regulator CFTR ATP-binding cassette sub-family C member 7 Channel conductance-controlling ATPase cAMP-dependent chloride channel
External Links
UniProt	P34158
EMBL	DP000027 L26098 M89906
PIR	I84733
RefSeq	NP_113694.1
UniGene	Rn.124539
ProteinModelPortal	P34158
SMR	P34158
BioGrid	246440
STRING	10116.ENSRNOP00000010981
BindingDB	P34158
ChEMBL	CHEMBL3992
PhosphoSite	P34158
PaxDb	P34158
PRIDE	P34158
Ensembl	ENSRNOT00000010981
GeneID	24255
KEGG	rno:24255
CTD	1080
RGD	2332
eggNOG	COG1132
GeneTree	ENSGT00770000120479
HOVERGEN	HBG004169
InParanoid	P34158
KO	K05031
OMA	NALRRCF
OrthoDB	EOG7C2R0B
PhylomeDB	P34158
TreeFam	TF105200
Reactome	REACT_230681
NextBio	602781
PRO	PR:P34158
Proteomes	UP000002494
Genevestigator	P34158
GO	GO:0016324 GO:0016323 GO:0009986 GO:0034707 GO:0005737 GO:0030659 GO:0005769 GO:0031901 GO:0031205 GO:0070062 GO:0005902 GO:0005886 GO:0005524 GO:0015106 GO:0005260 GO:0005254 GO:0019869 GO:0015108 GO:0015701 GO:0007589 GO:0071320 GO:0032870 GO:1902476 GO:0006821 GO:0006695 GO:0030301 GO:0051454 GO:0015705 GO:0030324 GO:0060081 GO:0045909 GO:1902943 GO:0034097 GO:0042493 GO:0043627 GO:0043434 GO:0048240 GO:0030321 GO:0042311 GO:0006833
Gene3D	3.40.50.300
InterPro	IPR003593 IPR011527 IPR003439 IPR017871 IPR009147 IPR025837 IPR027417
PANTHER	PTHR24223:SF19
Pfam	PF00664 PF00005 PF14396
PRINTS	PR01851
SMART	SM00382
SUPFAM	SSF52540 SSF90123
TIGRFAMs	TIGR01271
PROSITE	PS50929 PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29453757^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P	Seeded From UniProt	complete
involved_in	GO:0035377	transepithelial water transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P	Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F	Seeded From UniProt	complete
enables	GO:0005260	intracellularly ATP-gated chloride channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P	Seeded From UniProt	complete
involved_in	GO:1904322	cellular response to forskolin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	P	Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26361	P	Seeded From UniProt	complete
involved_in	GO:0060081	membrane hyperpolarization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26361	P	Seeded From UniProt	complete
involved_in	GO:0051454	intracellular pH elevation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26361	P	Seeded From UniProt	complete
involved_in	GO:0048240	sperm capacitation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26361	P	Seeded From UniProt	complete
enables	GO:0019869	chloride channel inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F	Seeded From UniProt	complete
enables	GO:0015108	chloride transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26361	F	Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26361	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	C	Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F	Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13569	F	Seeded From UniProt	complete
involved_in	GO:2000077	negative regulation of type B pancreatic cell development	PMID:23178930^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	PMID:24999019^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904446	positive regulation of establishment of Sertoli cell barrier	PMID:22777528^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:17596272^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	PMID:1378998^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071454	cellular response to anoxia	PMID:14975182^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:16051669^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:16614390^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:7529593^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:16916328^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042311	vasodilation	PMID:16859673^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:22777528^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:16051699^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033005	positive regulation of mast cell activation	PMID:11781380^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	PMID:17595518^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:11083465^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:7529593^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:15694001^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030321	transepithelial chloride transport	PMID:17122162^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:11083465^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:16575514^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0015705	iodide transport	PMID:17596272^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	PMID:19657734^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:25546515^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006833	water transport	PMID:19657734^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	PMID:19684200^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:16575514^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0005769	early endosome	PMID:7521124^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16575514^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88388 PANTHER:PTN000658665 UniProtKB:P13569	P	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:3112 SGD:S000002542 TAIR:locus:2061559 UniProtKB:A7KVC2 UniProtKB:Q10RX7	P	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:71101 TAIR:locus:2061559 UniProtKB:Q9LK64	F	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88388 PANTHER:PTN000658665 RGD:2332 UniProtKB:P13569	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352447 PANTHER:PTN000657997 RGD:2366 RGD:3112 RGD:620268 UniProtKB:O15439 UniProtKB:O15440	C	Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658665 RGD:2332 UniProtKB:P13569	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2443111 MGI:MGI:88388 PANTHER:PTN002384279 UniProtKB:O15439 UniProtKB:P13569	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88388 PANTHER:PTN000658665 UniProtKB:P13569	C	Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009147	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR011527 InterPro:IPR017871 InterPro:IPR036640	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009147	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009147	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527 InterPro:IPR036640	C	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F	Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	F	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0034707	chloride channel complex	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0005254	chloride channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
involved_in	GO:0006821	chloride transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0869	P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C	Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0231	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sharma, S et al. (2018) Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa. J. Mol. Histol. 49 195-208 PubMed GONUTS page
↑ Zertal-Zidani, S et al. (2013) Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse. Diabetologia 56 330-9 PubMed GONUTS page
↑ Zeng, JW et al. (2014) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells. Apoptosis 19 1317-29 PubMed GONUTS page
↑ ^4.0 ^4.1 Chen, J et al. (2012) Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Hum. Reprod. 27 2585-97 PubMed GONUTS page
↑ ^5.0 ^5.1 Robert, R et al. (2007) Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries. Eur. Respir. J. 30 857-64 PubMed GONUTS page
↑ Tran-Paterson, R et al. (1992) Expression and regulation of the cystic fibrosis gene during rat liver regeneration. Am. J. Physiol. 263 C55-60 PubMed GONUTS page
↑ Uramoto, H et al. (2003) Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes. Jpn. J. Physiol. 53 357-65 PubMed GONUTS page
↑ Ajonuma, LC et al. (2005) Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome. Mol. Endocrinol. 19 3038-44 PubMed GONUTS page
↑ Novaira, HJ et al. (2006) Atrial natriuretic peptide modulates cystic fibrosis transmembrane conductance regulator chloride channel expression in rat proximal colon and human intestinal epithelial cells. J. Endocrinol. 189 155-65 PubMed GONUTS page
↑ ^10.0 ^10.1 Mulberg, AE et al. (1994) Cystic fibrosis transmembrane conductance regulator protein expression in brain. Neuroreport 5 1684-8 PubMed GONUTS page
↑ Gu, X et al. (2006) Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs. Respirology 11 566-71 PubMed GONUTS page
↑ Valero, MS et al. (2006) Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta. Eur. J. Pharmacol. 544 126-31 PubMed GONUTS page
↑ Kulka, M et al. (2005) Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J. Pharmacol. Exp. Ther. 315 563-70 PubMed GONUTS page
↑ Kulka, M et al. (2002) Expression and functional characterization of CFTR in mast cells. J. Leukoc. Biol. 71 54-64 PubMed GONUTS page
↑ de Andrade Pinto, AC et al. (2007) Thyroid hormones stimulate renal expression of CFTR. Cell. Physiol. Biochem. 20 83-90 PubMed GONUTS page
↑ ^16.0 ^16.1 Ameen, NA et al. (2000) Subcellular distribution of CFTR in rat intestine supports a physiologic role for CFTR regulation by vesicle traffic. Histochem. Cell Biol. 114 219-28 PubMed GONUTS page
↑ Cohen, JC & Larson, JE (2005) Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung. BMC Dev. Biol. 5 2 PubMed GONUTS page
↑ Ishibashi, K et al. (2006) Roles of CLCA and CFTR in electrolyte re-absorption from rat saliva. J. Dent. Res. 85 1101-5 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Ogata, T (2006) Bicarbonate secretion by rat bile duct brush cells indicated by immunohistochemical localization of CFTR, anion exchanger AE2, Na+/HCO3 -cotransporter, carbonic anhydrase II, Na+/H+ exchangers NHE1 and NHE3, H+/K+-ATPase, and Na+/K+-ATPase. Med Mol Morphol 39 44-8 PubMed GONUTS page
↑ ^20.0 ^20.1 Mizumori, M et al. (2009) Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig. Dis. Sci. 54 2063-9 PubMed GONUTS page
↑ Xie, C et al. (2015) Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. J. Cell. Physiol. 230 1906-15 PubMed GONUTS page
↑ Johnson, M et al. (2009) Characteristics of Cl- uptake in rat alveolar type I cells. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L816-27 PubMed GONUTS page
↑ Webster, P et al. (1994) Subcellular localization of CFTR to endosomes in a ductal epithelium. Am. J. Physiol. 267 C340-8 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29453757-1] Sharma, S et al. (2018) Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa. J. Mol. Histol. 49 195-208 PubMed GONUTS page

[PMID:23178930-2] Zertal-Zidani, S et al. (2013) Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse. Diabetologia 56 330-9 PubMed GONUTS page

[PMID:24999019-3] Zeng, JW et al. (2014) Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells. Apoptosis 19 1317-29 PubMed GONUTS page

[PMID:22777528-4] 4.0 ^4.1 Chen, J et al. (2012) Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-κB/COX-2/PGE2. Hum. Reprod. 27 2585-97 PubMed GONUTS page

[PMID:17596272-5] 5.0 ^5.1 Robert, R et al. (2007) Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries. Eur. Respir. J. 30 857-64 PubMed GONUTS page

[PMID:1378998-6] Tran-Paterson, R et al. (1992) Expression and regulation of the cystic fibrosis gene during rat liver regeneration. Am. J. Physiol. 263 C55-60 PubMed GONUTS page

[PMID:14975182-7] Uramoto, H et al. (2003) Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes. Jpn. J. Physiol. 53 357-65 PubMed GONUTS page

[PMID:16051669-8] Ajonuma, LC et al. (2005) Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome. Mol. Endocrinol. 19 3038-44 PubMed GONUTS page

[PMID:16614390-9] Novaira, HJ et al. (2006) Atrial natriuretic peptide modulates cystic fibrosis transmembrane conductance regulator chloride channel expression in rat proximal colon and human intestinal epithelial cells. J. Endocrinol. 189 155-65 PubMed GONUTS page

[PMID:7529593-10] 10.0 ^10.1 Mulberg, AE et al. (1994) Cystic fibrosis transmembrane conductance regulator protein expression in brain. Neuroreport 5 1684-8 PubMed GONUTS page

[PMID:16916328-11] Gu, X et al. (2006) Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs. Respirology 11 566-71 PubMed GONUTS page

[PMID:16859673-12] Valero, MS et al. (2006) Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta. Eur. J. Pharmacol. 544 126-31 PubMed GONUTS page

[PMID:16051699-13] Kulka, M et al. (2005) Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J. Pharmacol. Exp. Ther. 315 563-70 PubMed GONUTS page

[PMID:11781380-14] Kulka, M et al. (2002) Expression and functional characterization of CFTR in mast cells. J. Leukoc. Biol. 71 54-64 PubMed GONUTS page

[PMID:17595518-15] Andrade Pinto, AC et al. (2007) Thyroid hormones stimulate renal expression of CFTR. Cell. Physiol. Biochem. 20 83-90 PubMed GONUTS page

[PMID:11083465-16] 16.0 ^16.1 Ameen, NA et al. (2000) Subcellular distribution of CFTR in rat intestine supports a physiologic role for CFTR regulation by vesicle traffic. Histochem. Cell Biol. 114 219-28 PubMed GONUTS page

[PMID:15694001-17] Cohen, JC & Larson, JE (2005) Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung. BMC Dev. Biol. 5 2 PubMed GONUTS page

[PMID:17122162-18] Ishibashi, K et al. (2006) Roles of CLCA and CFTR in electrolyte re-absorption from rat saliva. J. Dent. Res. 85 1101-5 PubMed GONUTS page

[PMID:16575514-19] 19.0 ^19.1 ^19.2 Ogata, T (2006) Bicarbonate secretion by rat bile duct brush cells indicated by immunohistochemical localization of CFTR, anion exchanger AE2, Na+/HCO3 -cotransporter, carbonic anhydrase II, Na+/H+ exchangers NHE1 and NHE3, H+/K+-ATPase, and Na+/K+-ATPase. Med Mol Morphol 39 44-8 PubMed GONUTS page

[PMID:19657734-20] 20.0 ^20.1 Mizumori, M et al. (2009) Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig. Dis. Sci. 54 2063-9 PubMed GONUTS page

[PMID:25546515-21] Xie, C et al. (2015) Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. J. Cell. Physiol. 230 1906-15 PubMed GONUTS page

[PMID:19684200-22] Johnson, M et al. (2009) Characteristics of Cl- uptake in rat alveolar type I cells. Am. J. Physiol. Lung Cell Mol. Physiol. 297 L816-27 PubMed GONUTS page

[PMID:7521124-23] Webster, P et al. (1994) Subcellular localization of CFTR to endosomes in a ductal epithelium. Am. J. Physiol. 267 C340-8 PubMed GONUTS page

[PMID:21873635-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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