RAT:CAC1D

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cacna1d (synonyms: Cach3, Cacn4, Cacnl1a2, Cchl1a2)
Protein Name(s)	Voltage-dependent L-type calcium channel subunit alpha-1D Calcium channel, L type, alpha-1 polypeptide, isoform 2 Rat brain class D RBD Voltage-gated calcium channel subunit alpha Cav1.3
External Links
UniProt	P27732
EMBL	D38101 D38102 M57682 U14005 M99221 U31772 U49126 U49127 U49128
PIR	JH0422 T42742
RefSeq	NP_058994.1
UniGene	Rn.89671
ProteinModelPortal	P27732
SMR	P27732
DIP	DIP-60740N
IntAct	P27732
MINT	MINT-7965882
BindingDB	P27732
ChEMBL	CHEMBL4132
GuidetoPHARMACOLOGY	530
TCDB	1.A.1.11.1
PhosphoSite	P27732
PaxDb	P27732
PRIDE	P27732
GeneID	29716
KEGG	rno:29716
CTD	776
RGD	70973
eggNOG	COG1226
HOVERGEN	HBG050763
InParanoid	P27732
KO	K04851
PhylomeDB	P27732
Reactome	REACT_232206
NextBio	610169
PRO	PR:P27732
Proteomes	UP000002494
Genevestigator	P27732
GO	GO:0016324 GO:0030425 GO:0032590 GO:0043025 GO:0005634 GO:0005886 GO:0042383 GO:0005891 GO:0030506 GO:0008331 GO:0046872 GO:0030165 GO:0005245 GO:0086007 GO:0007568 GO:0070509 GO:0006816 GO:0019722 GO:0070838 GO:0007507 GO:0086010 GO:0086012 GO:0007613 GO:0032793 GO:0051924
Gene3D	1.20.120.350
InterPro	IPR027359 IPR005821 IPR005452 IPR014873 IPR005446 IPR002077
PANTHER	PTHR10037:SF139
Pfam	PF08763 PF00520
PRINTS	PR00167 PR01630 PR01636
SMART	SM01062

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045762	positive regulation of adenylate cyclase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99246	P	Seeded From UniProt	complete
involved_in	GO:0086012	membrane depolarization during cardiac muscle cell action potential	PMID:21859974^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005245	P	Seeded From UniProt	complete
enables	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	PMID:21859974^[1]	ECO:0000305	curator inference used in manual assertion	GO:0005245	F	Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	PMID:21859974^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030506	ankyrin binding	PMID:21859974^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01484	F	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:21859974^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:21859974^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	PMID:25675390^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:21822937^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070838	divalent metal ion transport	PMID:17287512^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:16706838^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:19136044^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:21378599^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:23229155^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032793	positive regulation of CREB transcription factor activity	PMID:16706838^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:16706838^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	PMID:19593990^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:19136044^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:17287512^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	PMID:7479909^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:17272350^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:14637163^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21822937^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:18322004^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:12591156^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:12425941^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21378599^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19136044^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14534084^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21378599^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:11487617^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001295314 RGD:2244 RGD:2245 RGD:2246 RGD:628852 RGD:70973 UniProtKB:Q01668	P	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88293 PANTHER:PTN000004694 RGD:2245 RGD:70973 RGD:70983 UniProtKB:O60840 UniProtKB:Q01668 UniProtKB:Q13698 UniProtKB:Q13936	F	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263111 MGI:MGI:103013 MGI:MGI:106217 MGI:MGI:109482 MGI:MGI:88294 MGI:MGI:88296 PANTHER:PTN001295293 RGD:2244 RGD:2245 RGD:628852 RGD:70973 RGD:70983 SGD:S000003449 UniProtKB:Q01668 UniProtKB:Q13698 ZFIN:ZDB-GENE-020129-1	P	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001991 FB:FBgn0263111 MGI:MGI:103013 MGI:MGI:106217 MGI:MGI:109482 MGI:MGI:1859639 MGI:MGI:88294 MGI:MGI:88296 PANTHER:PTN001295314 RGD:2244 RGD:2245 RGD:2246 RGD:628852 RGD:70973 UniProtKB:O00555 UniProtKB:O60840 UniProtKB:Q01668 UniProtKB:Q13698 UniProtKB:Q13936 UniProtKB:Q15878 WB:WBGene00001187	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002077 InterPro:IPR005446 InterPro:IPR005452	F	Seeded From UniProt	complete
part_of	GO:0005891	voltage-gated calcium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002077 InterPro:IPR005446 InterPro:IPR005452	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002077 InterPro:IPR005446 InterPro:IPR005452	P	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Cunha, SR et al. (2011) Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation 124 1212-22 PubMed GONUTS page
↑ Lichvárová, L & Lacinová, Ľ (2015) Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells. Gen. Physiol. Biophys. 34 157-65 PubMed GONUTS page
↑ ^3.0 ^3.1 Kim, S & Rhim, H (2011) Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Mol. Cells 32 289-94 PubMed GONUTS page
↑ ^4.0 ^4.1 Calin-Jageman, I et al. (2007) Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit. J. Neurosci. 27 1374-85 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhang, H et al. (2006) Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. Eur. J. Neurosci. 23 2297-310 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Sukiasyan, N et al. (2009) Distribution of calcium channel Ca(V)1.3 immunoreactivity in the rat spinal cord and brain stem. Neuroscience 159 217-35 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Qu, Y et al. (2011) Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart. Pediatr. Res. 69 479-84 PubMed GONUTS page
↑ Reinbothe, TM et al. (2013) The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes. Diabetologia 56 340-9 PubMed GONUTS page
↑ Zhou, QG et al. (2009) [Estrogen reduces the expressions of ryanodine receptor type 1 and Cav1.3 L-type calcium channel in the vaginal smooth muscle cells of rats]. Zhonghua Nan Ke Xue 15 511-6 PubMed GONUTS page
↑ Barry, EL et al. (1995) Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone. Proc. Natl. Acad. Sci. U.S.A. 92 10914-8 PubMed GONUTS page
↑ Morgan, EL et al. (2007) Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. J. Physiol. (Lond.) 580 593-604 PubMed GONUTS page
↑ Morgan, EL et al. (2003) A role for Ca(v)1.3 in rat intestinal calcium absorption. Biochem. Biophys. Res. Commun. 312 487-93 PubMed GONUTS page
↑ Grant, L & Fuchs, P (2008) Calcium- and calmodulin-dependent inactivation of calcium channels in inner hair cells of the rat cochlea. J. Neurophysiol. 99 2183-93 PubMed GONUTS page
↑ Veng, LM et al. (2003) Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment. Brain Res. Mol. Brain Res. 110 193-202 PubMed GONUTS page
↑ Veng, LM & Browning, MD (2002) Regionally selective alterations in expression of the alpha(1D) subunit (Ca(v)1.3) of L-type calcium channels in the hippocampus of aged rats. Brain Res. Mol. Brain Res. 107 120-7 PubMed GONUTS page
↑ Huang, L et al. (2004) [Ca2+]i regulates trafficking of Cav1.3 (alpha1D Ca2+ channel) in insulin-secreting cells. Am. J. Physiol., Cell Physiol. 286 C213-21 PubMed GONUTS page
↑ Xu, W & Lipscombe, D (2001) Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J. Neurosci. 21 5944-51 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21859974-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Cunha, SR et al. (2011) Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation 124 1212-22 PubMed GONUTS page

[PMID:25675390-2] Lichvárová, L & Lacinová, Ľ (2015) Ca(V)1.2 and Ca(V)1.3 L-type calcium channels regulate the resting membrane potential but not the expression of calcium transporters in differentiated PC12 cells. Gen. Physiol. Biophys. 34 157-65 PubMed GONUTS page

[PMID:21822937-3] 3.0 ^3.1 Kim, S & Rhim, H (2011) Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Mol. Cells 32 289-94 PubMed GONUTS page

[PMID:17287512-4] 4.0 ^4.1 Calin-Jageman, I et al. (2007) Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunit. J. Neurosci. 27 1374-85 PubMed GONUTS page

[PMID:16706838-5] 5.0 ^5.1 ^5.2 Zhang, H et al. (2006) Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB. Eur. J. Neurosci. 23 2297-310 PubMed GONUTS page

[PMID:19136044-6] 6.0 ^6.1 ^6.2 Sukiasyan, N et al. (2009) Distribution of calcium channel Ca(V)1.3 immunoreactivity in the rat spinal cord and brain stem. Neuroscience 159 217-35 PubMed GONUTS page

[PMID:21378599-7] 7.0 ^7.1 ^7.2 Qu, Y et al. (2011) Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart. Pediatr. Res. 69 479-84 PubMed GONUTS page

[PMID:23229155-8] Reinbothe, TM et al. (2013) The human L-type calcium channel Cav1.3 regulates insulin release and polymorphisms in CACNA1D associate with type 2 diabetes. Diabetologia 56 340-9 PubMed GONUTS page

[PMID:19593990-9] Zhou, QG et al. (2009) [Estrogen reduces the expressions of ryanodine receptor type 1 and Cav1.3 L-type calcium channel in the vaginal smooth muscle cells of rats]. Zhonghua Nan Ke Xue 15 511-6 PubMed GONUTS page

[PMID:7479909-10] Barry, EL et al. (1995) Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone. Proc. Natl. Acad. Sci. U.S.A. 92 10914-8 PubMed GONUTS page

[PMID:17272350-11] Morgan, EL et al. (2007) Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. J. Physiol. (Lond.) 580 593-604 PubMed GONUTS page

[PMID:14637163-12] Morgan, EL et al. (2003) A role for Ca(v)1.3 in rat intestinal calcium absorption. Biochem. Biophys. Res. Commun. 312 487-93 PubMed GONUTS page

[PMID:18322004-13] Grant, L & Fuchs, P (2008) Calcium- and calmodulin-dependent inactivation of calcium channels in inner hair cells of the rat cochlea. J. Neurophysiol. 99 2183-93 PubMed GONUTS page

[PMID:12591156-14] Veng, LM et al. (2003) Age-related working memory impairment is correlated with increases in the L-type calcium channel protein alpha1D (Cav1.3) in area CA1 of the hippocampus and both are ameliorated by chronic nimodipine treatment. Brain Res. Mol. Brain Res. 110 193-202 PubMed GONUTS page

[PMID:12425941-15] Veng, LM & Browning, MD (2002) Regionally selective alterations in expression of the alpha(1D) subunit (Ca(v)1.3) of L-type calcium channels in the hippocampus of aged rats. Brain Res. Mol. Brain Res. 107 120-7 PubMed GONUTS page

[PMID:14534084-16] Huang, L et al. (2004) [Ca2+]i regulates trafficking of Cav1.3 (alpha1D Ca2+ channel) in insulin-secreting cells. Am. J. Physiol., Cell Physiol. 286 C213-21 PubMed GONUTS page

[PMID:11487617-17] Xu, W & Lipscombe, D (2001) Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J. Neurosci. 21 5944-51 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:CAC1D

Contents

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References

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