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RAT:BKRB2

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Bdkrb2
Protein Name(s) B2 bradykinin receptor

B2R BK-2 receptor

External Links
UniProt P25023
EMBL M59967
M59967
X80187
X80188
X80189
X80190
L26173
X69681
PIR A41283
RefSeq NP_775123.2
UniGene Rn.9845
ProteinModelPortal P25023
STRING 10116.ENSRNOP00000035441
BindingDB P25023
ChEMBL CHEMBL2501
GuidetoPHARMACOLOGY 42
PhosphoSite P25023
PaxDb P25023
PRIDE P25023
Ensembl ENSRNOT00000071735
GeneID 25245
KEGG rno:25245
UCSC RGD:2201
CTD 624
RGD 2201
eggNOG NOG148810
GeneTree ENSGT00760000119055
HOGENOM HOG000010314
HOVERGEN HBG103183
InParanoid P25023
KO K03916
OrthoDB EOG7HHWSV
PhylomeDB P25023
Reactome REACT_233455
REACT_250028
REACT_263374
NextBio 605845
PRO PR:P25023
Proteomes UP000002494
ExpressionAtlas P25023
Genevestigator P25023
GO GO:0016021
GO:0005886
GO:0031698
GO:0004947
GO:0002438
GO:0071456
GO:0035633
GO:0045776
GO:0008285
GO:0007204
GO:0042493
GO:0019233
GO:0006939
GO:0042310
InterPro IPR001504
IPR000496
IPR000276
IPR017452
Pfam PF00001
PRINTS PR00425
PR00994
PR00237
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050767

regulation of neurogenesis

PMID:23132855[1]

ECO:0000314

P

Figure 5 shows increased and decreased Neural Progenitor Cell migration based on B2BkR activation or inhibition.

complete

involved_in

GO:0071456

cellular response to hypoxia

PMID:19565561[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045776

negative regulation of blood pressure

PMID:16507603[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:18190998[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035633

maintenance of permeability of blood-brain barrier

PMID:20080302[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031698

beta-2 adrenergic receptor binding

PMID:20150590[6]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:2060

F

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:12177051[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:15576455[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:16754789[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004947

bradykinin receptor activity

PMID:1715575[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0002438

acute inflammatory response to antigenic stimulus

PMID:7791078[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[12]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025631
MGI:MGI:87964
PANTHER:PTN001200934
RGD:2070
RGD:2072
RGD:2201
RGD:620401
RGD:621645
UniProtKB:P30411
UniProtKB:P30556
UniProtKB:P35414
UniProtKB:P48039
UniProtKB:P49685
UniProtKB:Q13585
ZFIN:ZDB-GENE-141216-12

C

Seeded From UniProt

complete

enables

GO:0004947

bradykinin receptor activity

PMID:21873635[12]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002796037
RGD:2201
UniProtKB:P30411
ZFIN:ZDB-GENE-030814-1

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[12]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1918473
MGI:MGI:2441843
MGI:MGI:87964
MGI:MGI:87966
PANTHER:PTN001200934
RGD:2070
RGD:2201
RGD:620401
UniProtKB:P30411
UniProtKB:P30556
UniProtKB:P48039
UniProtKB:P49685
UniProtKB:P50052
ZFIN:ZDB-GENE-030814-1
ZFIN:ZDB-GENE-050913-90
ZFIN:ZDB-GENE-141216-12

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004947

bradykinin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000496
InterPro:IPR001504

F

Seeded From UniProt

complete

involved_in

GO:0006939

smooth muscle contraction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001504

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000496
InterPro:IPR001504

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000496
InterPro:IPR001504
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0042310

vasoconstriction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001504

P

Seeded From UniProt

complete

involved_in

GO:0019233

sensory perception of pain

PMID:1715575[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Trujillo, CA et al. (2012) Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. J. Biol. Chem. 287 44046-61 PubMed GONUTS page
  2. ↑ Liesmaa, I et al. (2009) Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis. J. Cell. Physiol. 221 359-66 PubMed GONUTS page
  3. ↑ Duka, A et al. (2006) Role of bradykinin B1 and B2 receptors in normal blood pressure regulation. Am. J. Physiol. Endocrinol. Metab. 291 E268-74 PubMed GONUTS page
  4. ↑ Rastelli, VM et al. (2008) Enalapril treatment corrects the reduced response to bradykinin in diabetes increasing the B2 protein expression. Peptides 29 404-11 PubMed GONUTS page
  5. ↑ Côté, J et al. (2010) Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study. Neuropeptides 44 177-85 PubMed GONUTS page
  6. ↑ Haack, KK et al. (2010) A novel bioassay for detecting GPCR heterodimerization: transactivation of beta 2 adrenergic receptor by bradykinin receptor. J Biomol Screen 15 251-60 PubMed GONUTS page
  7. ↑ Duchene, J et al. (2002) A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. J. Biol. Chem. 277 40375-83 PubMed GONUTS page
  8. ↑ Chopra, B et al. (2005) Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J. Physiol. (Lond.) 562 859-71 PubMed GONUTS page
  9. ↑ Abadir, PM et al. (2006) Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization. Hypertension 48 316-22 PubMed GONUTS page
  10. ↑ 10.0 10.1 McEachern, AE et al. (1991) Expression cloning of a rat B2 bradykinin receptor. Proc. Natl. Acad. Sci. U.S.A. 88 7724-8 PubMed GONUTS page
  11. ↑ Félétou, M et al. (1995) Effects of the bradykinin B2 receptor antagonist S 16118 (p-guanidobenzoyl-[Hyp3,Thi5,D-Tic7,Oic8]bradykinin) in different in vivo animal models of inflammation. J. Pharmacol. Exp. Ther. 273 1078-84 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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