RAT:ARC

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Arc (ECO:0000312 with RGD:62037)
Protein Name(s)	Activity-regulated cytoskeleton-associated protein ARC/ARG3.1 Activity-regulated gene 3.1 protein Arg3.1
External Links
UniProt	Q63053
EMBL	U19866 Z46925
PIR	I58168
RefSeq	NP_062234.1 XP_008763812.1 XP_008763813.1
UniGene	Rn.10086
ProteinModelPortal	Q63053
BioGrid	248539
IntAct	Q63053
PhosphoSite	Q63053
PaxDb	Q63053
PRIDE	Q63053
Ensembl	ENSRNOT00000067442 ENSRNOT00000076998
GeneID	54323
KEGG	rno:54323
UCSC	RGD:62037
CTD	23237
RGD	62037
eggNOG	NOG81608
GeneTree	ENSGT00390000003914
HOGENOM	HOG000034037
HOVERGEN	HBG080862
InParanoid	Q63053
KO	K15867
OMA	RCQETIA
OrthoDB	EOG75B855
PhylomeDB	Q63053
TreeFam	TF335604
NextBio	611018
PRO	PR:Q63053
Proteomes	UP000002494
Genevestigator	Q63053
GO	GO:0001669 GO:0015629 GO:0005938 GO:0030054 GO:0005737 GO:0043197 GO:0005768 GO:0014069 GO:0045211 GO:0009952 GO:0016477 GO:0007010 GO:0006897 GO:0007492 GO:0007612 GO:0022604 GO:0048168
InterPro	IPR023263
PANTHER	PTHR15962
PRINTS	PR02027

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:17088211^[1]	ECO:0000315			P		Figure 6	complete CACAO 2870
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV31	C		Seeded From UniProt	complete
involved_in	GO:1900452	regulation of long-term synaptic depression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WV31	P		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:10818134^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:10818134^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:29328916^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	PMID:29328916^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:29328916^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1903561	extracellular vesicle	PMID:29328916^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0110077	vesicle-mediated intercellular transport	PMID:29328916^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061001	regulation of dendritic spine morphogenesis	PMID:15537891^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	PMID:17088211^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:17898216^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002608) occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0022604	regulation of cell morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7LC44	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17088211^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17088211^[1]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17088211^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098845	postsynaptic endosome	PMID:17088211^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098845	postsynaptic endosome	PMID:17088211^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:17088211^[1]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:17088211^[1]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:17088211^[1]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:17898216^[5]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:17898216^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	PMID:7857651^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:7857651^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007612	learning	PMID:20111591^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000969	positive regulation of AMPA receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	P		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 RGD:62037	C		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 UniProtKB:Q7LC44	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 UniProtKB:Q7LC44	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000409796 UniProtKB:Q7LC44	C		Seeded From UniProt	complete
involved_in	GO:0022604	regulation of cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7LC44 ensembl:ENSP00000349022	C		Seeded From UniProt	complete
involved_in	GO:1900452	regulation of long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV31 ensembl:ENSMUSP00000023268	P		Seeded From UniProt	complete
involved_in	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV31 ensembl:ENSMUSP00000023268	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV31 ensembl:ENSMUSP00000023268	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV31 ensembl:ENSMUSP00000023268	C		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV31 ensembl:ENSMUSP00000023268	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WV31 ensembl:ENSMUSP00000023268	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12451105^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0007	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Chowdhury, S et al. (2006) Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52 445-59 PubMed GONUTS page
↑ ^2.0 ^2.1 Guzowski, JF et al. (2000) Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20 3993-4001 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Pastuzyn, ED et al. (2018) The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell 172 275-288.e18 PubMed GONUTS page
↑ Lacor, PN et al. (2004) Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J. Neurosci. 24 10191-200 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Messaoudi, E et al. (2007) Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J. Neurosci. 27 10445-55 PubMed GONUTS page
↑ ^6.0 ^6.1 Lyford, GL et al. (1995) Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14 433-45 PubMed GONUTS page
↑ Rapanelli, M et al. (2010) Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory. PLoS ONE 5 e8656 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Vazdarjanova, A et al. (2002) Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J. Neurosci. 22 10067-71 PubMed GONUTS page

[PMID:17088211-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Chowdhury, S et al. (2006) Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52 445-59 PubMed GONUTS page

[PMID:10818134-2] 2.0 ^2.1 Guzowski, JF et al. (2000) Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20 3993-4001 PubMed GONUTS page

[PMID:29328916-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Pastuzyn, ED et al. (2018) The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer. Cell 172 275-288.e18 PubMed GONUTS page

[PMID:15537891-4] Lacor, PN et al. (2004) Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J. Neurosci. 24 10191-200 PubMed GONUTS page

[PMID:17898216-5] 5.0 ^5.1 ^5.2 Messaoudi, E et al. (2007) Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J. Neurosci. 27 10445-55 PubMed GONUTS page

[PMID:7857651-6] 6.0 ^6.1 Lyford, GL et al. (1995) Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14 433-45 PubMed GONUTS page

[PMID:20111591-7] Rapanelli, M et al. (2010) Plasticity in the rat prefrontal cortex: linking gene expression and an operant learning with a computational theory. PLoS ONE 5 e8656 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12451105-9] Vazdarjanova, A et al. (2002) Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J. Neurosci. 22 10067-71 PubMed GONUTS page

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RAT:ARC

Contents

Annotations

Notes

References

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