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PMID:12451105
| Citation |
Vazdarjanova, A, McNaughton, BL, Barnes, CA, Worley, PF and Guzowski, JF (2002) Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J. Neurosci. 22:10067-71 |
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| Abstract |
The transcription of the immediate-early genes Arc and Homer 1a (H1a) is dynamically regulated in response to synaptic activity; their protein products function at the postsynaptic sites of excitatory synapses. Previous studies demonstrate a role for Arc in the maintenance of long-term potentiation and in memory consolidation processes and indicate a role for H1a in modifying glutamatergic signaling pathways. Using double-label fluorescence in situ hybridization, we demonstrate that Arc and H1a RNA expression is induced strongly in the same neurons of rat hippocampus and neocortex after exploration of a novel environment. These findings support the view that novel experience activates a cell-specific genomic program and that Arc and H1a may function in concert in the structural and functional modifications of dendrites that lead to long-term changes in synaptic efficacy. |
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| Keywords |
3' Untranslated Regions/analysis; Animals; Carrier Proteins/biosynthesis; Carrier Proteins/genetics; Cell Nucleus/metabolism; Cytoskeletal Proteins/biosynthesis; Cytoskeletal Proteins/genetics; Dendrites/metabolism; Electroshock; Exploratory Behavior/physiology; Genes, Immediate-Early/physiology; Hippocampus/cytology; Hippocampus/metabolism; In Situ Hybridization, Fluorescence; Male; Neocortex/cytology; Neocortex/metabolism; Nerve Net/cytology; Nerve Net/metabolism; Nerve Tissue Proteins/biosynthesis; Nerve Tissue Proteins/genetics; Neuronal Plasticity/physiology; Neurons/cytology; Neurons/metabolism; Neuropeptides/biosynthesis; Neuropeptides/genetics; Protein Isoforms/biosynthesis; Protein Isoforms/genetics; RNA, Messenger/analysis; RNA, Messenger/biosynthesis; Rats; Rats, Sprague-Dawley; Spatial Behavior/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005737: cytoplasm |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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