RAT:AOFB

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Maob
Protein Name(s)	Amine oxidase [flavin-containing] B Monoamine oxidase type B MAO-B
External Links
UniProt	P19643
EMBL	M23601 BC089814
PIR	A31870
RefSeq	NP_037330.1
UniGene	Rn.6656
ProteinModelPortal	P19643
SMR	P19643
BindingDB	P19643
ChEMBL	CHEMBL2095196
GuidetoPHARMACOLOGY	2490
PaxDb	P19643
PRIDE	P19643
DNASU	25750
GeneID	25750
KEGG	rno:25750
UCSC	RGD:3041
CTD	4129
RGD	3041
eggNOG	COG1231
HOGENOM	HOG000221615
HOVERGEN	HBG004255
InParanoid	P19643
KO	K00274
PhylomeDB	P19643
BRENDA	1.4.3.4
Reactome	REACT_230115
SABIO-RK	P19643
NextBio	607939
PRO	PR:P19643
Proteomes	UP000002494
ExpressionAtlas	P19643
Genevestigator	P19643
GO	GO:0070062 GO:0016021 GO:0005743 GO:0005741 GO:0050660 GO:0008131 GO:0042803 GO:0014063 GO:0042135 GO:0045964 GO:0010044 GO:0051412 GO:0042493 GO:0045471 GO:0032496 GO:0010269 GO:0048545 GO:0009636 GO:0021762
Gene3D	3.40.50.720
InterPro	IPR002937 IPR001613 IPR016040
Pfam	PF01593
PRINTS	PR00757

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051412	response to corticosterone	PMID:15919584^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:18424170^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	PMID:18539264^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045964	positive regulation of dopamine metabolic process	PMID:12175458^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:20022592^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18198902^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18256746^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042135	neurotransmitter catabolic process	PMID:18539264^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:19779138^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014063	negative regulation of serotonin secretion	PMID:12175458^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010269	response to selenium ion	PMID:18304392^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010044	response to aluminum ion	PMID:19526156^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:16904659^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008131	primary amine oxidase activity	PMID:18424170^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:18502718^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001613 InterPro:IPR002937	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001613 InterPro:IPR002937	P	Seeded From UniProt	complete
involved_in	GO:0042135	neurotransmitter catabolic process	PMID:12379239^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008131	primary amine oxidase activity	PMID:12379239^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:12379239^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lindley, SE et al. (2005) Monoamine oxidase and catechol-o-methyltransferase enzyme activity and gene expression in response to sustained glucocorticoids. Psychoneuroendocrinology 30 785-90 PubMed GONUTS page
↑ ^2.0 ^2.1 Upadhyay, AK & Edmondson, DE (2008) Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris. Protein Expr. Purif. 59 349-56 PubMed GONUTS page
↑ ^3.0 ^3.1 Birgner, C et al. (2008) Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Brain Res. 1219 103-10 PubMed GONUTS page
↑ ^4.0 ^4.1 Falk, EM et al. (2002) An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacol. Biochem. Behav. 72 617-22 PubMed GONUTS page
↑ Ou, XM et al. (2010) A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol. Psychiatry 67 855-63 PubMed GONUTS page
↑ Upadhyay, AK et al. (2008) Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy. Biochemistry 47 1554-66 PubMed GONUTS page
↑ Khudoerkov, RM et al. (2007) Structural, functional, and biochemical changes in the brain during modeling of dopamine system disturbances in rats. Bull. Exp. Biol. Med. 144 36-8 PubMed GONUTS page
↑ Ekuni, D et al. (2009) Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Am. J. Pathol. 175 1398-409 PubMed GONUTS page
↑ Tang, YL et al. (2008) Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats. Br. J. Nutr. 100 660-5 PubMed GONUTS page
↑ Zhang, J et al. (2009) Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Saudi Med J 30 760-6 PubMed GONUTS page
↑ Castoldi, AF et al. (2006) Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153). Brain Res. 1112 91-8 PubMed GONUTS page
↑ Huang, YH et al. () Immunocytochemical localization of monoamine oxidase type B in rat liver. Eur J Histochem 52 11-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Arai, R et al. (2002) Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B. Neuroscience 114 825-35 PubMed GONUTS page

[PMID:15919584-1] Lindley, SE et al. (2005) Monoamine oxidase and catechol-o-methyltransferase enzyme activity and gene expression in response to sustained glucocorticoids. Psychoneuroendocrinology 30 785-90 PubMed GONUTS page

[PMID:18424170-2] 2.0 ^2.1 Upadhyay, AK & Edmondson, DE (2008) Characterization of detergent purified recombinant rat liver monoamine oxidase B expressed in Pichia pastoris. Protein Expr. Purif. 59 349-56 PubMed GONUTS page

[PMID:18539264-3] 3.0 ^3.1 Birgner, C et al. (2008) Reduced activity of monoamine oxidase in the rat brain following repeated nandrolone decanoate administration. Brain Res. 1219 103-10 PubMed GONUTS page

[PMID:12175458-4] 4.0 ^4.1 Falk, EM et al. (2002) An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacol. Biochem. Behav. 72 617-22 PubMed GONUTS page

[PMID:20022592-5] Ou, XM et al. (2010) A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol. Psychiatry 67 855-63 PubMed GONUTS page

[PMID:18198902-6] Upadhyay, AK et al. (2008) Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy. Biochemistry 47 1554-66 PubMed GONUTS page

[PMID:18256746-7] Khudoerkov, RM et al. (2007) Structural, functional, and biochemical changes in the brain during modeling of dopamine system disturbances in rats. Bull. Exp. Biol. Med. 144 36-8 PubMed GONUTS page

[PMID:19779138-8] Ekuni, D et al. (2009) Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model. Am. J. Pathol. 175 1398-409 PubMed GONUTS page

[PMID:18304392-9] Tang, YL et al. (2008) Both inorganic and organic selenium supplements can decrease brain monoamine oxidase B enzyme activity in adult rats. Br. J. Nutr. 100 660-5 PubMed GONUTS page

[PMID:19526156-10] Zhang, J et al. (2009) Berberine and total base from rhizoma coptis chinensis attenuate brain injury in an aluminum-induced rat model of neurodegenerative disease. Saudi Med J 30 760-6 PubMed GONUTS page

[PMID:16904659-11] Castoldi, AF et al. (2006) Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153). Brain Res. 1112 91-8 PubMed GONUTS page

[PMID:18502718-12] Huang, YH et al. () Immunocytochemical localization of monoamine oxidase type B in rat liver. Eur J Histochem 52 11-8 PubMed GONUTS page

[PMID:12379239-13] 13.0 ^13.1 ^13.2 Arai, R et al. (2002) Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B. Neuroscience 114 825-35 PubMed GONUTS page

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RAT:AOFB

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