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PMID:20022592

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Citation

Ou, XM, Stockmeier, CA, Meltzer, HY, Overholser, JC, Jurjus, GJ, Dieter, L, Chen, K, Lu, D, Johnson, C, Youdim, MB, Austin, MC, Luo, J, Sawa, A, May, W and Shih, JC (2010) A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol. Psychiatry 67:855-63

Abstract

Alcoholism is a major psychiatric condition at least partly associated with ethanol (EtOH)-induced cell damage. Although brain cell loss has been reported in subjects with alcoholism, the molecular mechanism is unclear. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and monoamine oxidase B (MAO B) reportedly play a role in cellular dysfunction under stressful conditions and might contribute to EtOH-induced cell damage.

Links

PubMed PMC2854240 Online version:10.1016/j.biopsych.2009.10.032

Keywords

Alcoholism/pathology; Analysis of Variance; Animals; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Central Nervous System Depressants/adverse effects; Ethanol/adverse effects; Gene Expression Regulation/drug effects; Gene Expression Regulation/genetics; Glioblastoma; Glyceraldehyde-3-Phosphate Dehydrogenases/genetics; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism; Humans; Hydrogen Peroxide/metabolism; Immunoprecipitation/methods; In Situ Nick-End Labeling/methods; Male; Monoamine Oxidase/genetics; Monoamine Oxidase/metabolism; Monoamine Oxidase Inhibitors/pharmacology; Neuroblastoma; Neurons/drug effects; Neurons/metabolism; Prefrontal Cortex/drug effects; Prefrontal Cortex/metabolism; RNA, Messenger/metabolism; Rats; Rats, Wistar; Repressor Proteins/metabolism; Selegiline/pharmacology; Transfection/methods

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:AOFB

involved_in

GO:0045471: response to ethanol

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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