RAT:AOC3

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Aoc3
Protein Name(s)	Membrane primary amine oxidase Copper amine oxidase Semicarbazide-sensitive amine oxidase SSAO VP97 Vascular adhesion protein 1 VAP-1
External Links
UniProt	O08590
EMBL	AB195675 BC100613 U72632
RefSeq	NP_113770.2
UniGene	Rn.198327
BindingDB	O08590
ChEMBL	CHEMBL4592
PaxDb	O08590
PRIDE	O08590
Ensembl	ENSRNOT00000076820
GeneID	29473
KEGG	rno:29473
UCSC	RGD:62058
CTD	8639
RGD	62058
eggNOG	COG3733
GeneTree	ENSGT00510000046461
HOGENOM	HOG000233919
HOVERGEN	HBG004164
InParanoid	O08590
KO	K00276
NextBio	609300
PRO	PR:O08590
Proteomes	UP000002494
Genevestigator	O08590
GO	GO:0009986 GO:0005615 GO:0016021 GO:0043231 GO:0005886 GO:0052595 GO:0052594 GO:0005507 GO:0052596 GO:0008131 GO:0042803 GO:0048038 GO:0052593 GO:0007568 GO:0009308 GO:0007155 GO:0042755 GO:0002523 GO:0002675 GO:0010828 GO:0002687 GO:0008217 GO:0035902
Gene3D	2.70.98.20 3.10.450.40
InterPro	IPR000269 IPR015798 IPR016182 IPR015800 IPR015801 IPR015802
PANTHER	PTHR10638
Pfam	PF01179 PF02727 PF02728
PRINTS	PR00766
SUPFAM	SSF49998 SSF54416
PROSITE	PS01164 PS01165

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0048038	quinone binding	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	C	Seeded From UniProt	complete
involved_in	GO:0009308	amine metabolic process	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	P	Seeded From UniProt	complete
enables	GO:0008131	primary amine oxidase activity	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9653080^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16853	C	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:9083076^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17393059^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	PMID:17977742^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	PMID:11099833^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010828	positive regulation of glucose transmembrane transport	PMID:15000445^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:17385063^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008131	primary amine oxidase activity	PMID:17393059^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:2862249^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10048142^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002687	positive regulation of leukocyte migration	PMID:19635478^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002675	positive regulation of acute inflammatory response	PMID:17993604^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002523	leukocyte migration involved in inflammatory response	PMID:17993604^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902283	negative regulation of primary amine oxidase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067358 UniProtKB:Q16853	P	Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067358 UniProtKB:Q16853	P	Seeded From UniProt	complete
involved_in	GO:0009308	amine metabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067313 UniProtKB:Q16853	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067340 UniProtKB:P19801 UniProtKB:Q16853 UniProtKB:Q9TRC7	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067358 UniProtKB:Q16853	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067358 UniProtKB:Q16853	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067358 UniProtKB:Q16853	C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13140 PANTHER:PTN000067313 UniProtKB:P19801 UniProtKB:Q16853	F	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000269 InterPro:IPR015798 InterPro:IPR015800 InterPro:IPR015802 InterPro:IPR016182 InterPro:IPR036460	F	Seeded From UniProt	complete
enables	GO:0008131	primary amine oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000269 InterPro:IPR015798 InterPro:IPR015800 InterPro:IPR015802 InterPro:IPR016182 InterPro:IPR036460	F	Seeded From UniProt	complete
involved_in	GO:0009308	amine metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000269 InterPro:IPR015798 InterPro:IPR015800 InterPro:IPR015802 InterPro:IPR016182 InterPro:IPR036460	P	Seeded From UniProt	complete
enables	GO:0048038	quinone binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000269 InterPro:IPR015798 InterPro:IPR015800 InterPro:IPR015802 InterPro:IPR016182 InterPro:IPR036460	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000269 InterPro:IPR015798 InterPro:IPR015800 InterPro:IPR015802 InterPro:IPR016182 InterPro:IPR036460	P	Seeded From UniProt	complete
enables	GO:0008131	primary amine oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.4.3.21	F	Seeded From UniProt	complete
enables	GO:0052596	phenethylamine:oxygen oxidoreductase (deaminating) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.4.3.21	F	Seeded From UniProt	complete
enables	GO:0052595	aliphatic-amine oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.4.3.21	F	Seeded From UniProt	complete
enables	GO:0052594	aminoacetone:oxygen oxidoreductase(deaminating) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.4.3.21	F	Seeded From UniProt	complete
enables	GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.4.3.21	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Smith, DJ et al. (1998) Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. J. Exp. Med. 188 17-27 PubMed GONUTS page
↑ Morris, NJ et al. (1997) Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. J. Biol. Chem. 272 9388-92 PubMed GONUTS page
↑ ^3.0 ^3.1 Unzeta, M et al. (2007) Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer's disease. J Neural Transm (Vienna) 114 857-62 PubMed GONUTS page
↑ Carpéné, C et al. (2007) Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats. Pharmacol. Res. 56 522-30 PubMed GONUTS page
↑ Obata, T & Yamanaka, Y (2000) Evidence for existence of immobilization stress-inducible semicarbazide-sensitive amine oxidase inhibitor in rat brain cytosol. Neurosci. Lett. 296 58-60 PubMed GONUTS page
↑ Abella, A et al. (2003) Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats. J. Physiol. Biochem. 59 153-60 PubMed GONUTS page
↑ Vidrio, H & Medina, M (2007) Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. J Neural Transm (Vienna) 114 863-5 PubMed GONUTS page
↑ Cao Danh, H et al. (1985) Age-related changes in the activities of the amine metabolizing enzymes of rat eye. J. Pharm. Pharmacol. 37 357-61 PubMed GONUTS page
↑ Conklin, DJ et al. (1998) Contribution of serum and cellular semicarbazide-sensitive amine oxidase to amine metabolism and cardiovascular toxicity. Toxicol. Sci. 46 386-92 PubMed GONUTS page
↑ Noda, K et al. (2009) Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes. Exp. Eye Res. 89 774-81 PubMed GONUTS page
↑ ^11.0 ^11.1 O'Rourke, AM et al. (2008) Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity. J. Pharmacol. Exp. Ther. 324 867-75 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9653080-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Smith, DJ et al. (1998) Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. J. Exp. Med. 188 17-27 PubMed GONUTS page

[PMID:9083076-2] Morris, NJ et al. (1997) Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. J. Biol. Chem. 272 9388-92 PubMed GONUTS page

[PMID:17393059-3] 3.0 ^3.1 Unzeta, M et al. (2007) Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer's disease. J Neural Transm (Vienna) 114 857-62 PubMed GONUTS page

[PMID:17977742-4] Carpéné, C et al. (2007) Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats. Pharmacol. Res. 56 522-30 PubMed GONUTS page

[PMID:11099833-5] Obata, T & Yamanaka, Y (2000) Evidence for existence of immobilization stress-inducible semicarbazide-sensitive amine oxidase inhibitor in rat brain cytosol. Neurosci. Lett. 296 58-60 PubMed GONUTS page

[PMID:15000445-6] Abella, A et al. (2003) Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats. J. Physiol. Biochem. 59 153-60 PubMed GONUTS page

[PMID:17385063-7] Vidrio, H & Medina, M (2007) Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. J Neural Transm (Vienna) 114 863-5 PubMed GONUTS page

[PMID:2862249-8] Cao Danh, H et al. (1985) Age-related changes in the activities of the amine metabolizing enzymes of rat eye. J. Pharm. Pharmacol. 37 357-61 PubMed GONUTS page

[PMID:10048142-9] Conklin, DJ et al. (1998) Contribution of serum and cellular semicarbazide-sensitive amine oxidase to amine metabolism and cardiovascular toxicity. Toxicol. Sci. 46 386-92 PubMed GONUTS page

[PMID:19635478-10] Noda, K et al. (2009) Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes. Exp. Eye Res. 89 774-81 PubMed GONUTS page

[PMID:17993604-11] 11.0 ^11.1 O'Rourke, AM et al. (2008) Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity. J. Pharmacol. Exp. Ther. 324 867-75 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:AOC3

Contents

Annotations

Notes

References

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