GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:2862249

From GONUTS
Jump to: navigation, search
Citation

Cao Danh, H, Strolin Benedetti, M, Mousset, A and Pasquier-Béchet, P (1985) Age-related changes in the activities of the amine metabolizing enzymes of rat eye. J. Pharm. Pharmacol. 37:357-61

Abstract

Eye MAO-A, MAO-B, semicarbazide-sensitive amine oxidase (SSAO) and aldehyde reductase (AR) activities were measured in young and old rats. When enzyme activity is expressed as nmol (mg protein)-1 min-1, a significant decrease (18-23%) of SSAO activity in the eye of old rats was found, whereas there was no significant difference in MAO-A and MAO-B activities. A significant increase of AR activity with D-xylose (67%), DL-glyceraldehyde (64%), D-glucuronate (43%) and D-glucose (21%) was found in the eye of old rats. These results suggest that changes in the activities of the amine metabolizing enzymes of rat eye with age might have consequences for their function in senescence; particularly, the increase of AR activity might be involved in cataract formation.

Links

PubMed

Keywords

Aging; Alcohol Oxidoreductases/metabolism; Amine Oxidase (Copper-Containing); Amines/metabolism; Animals; Benzylamine Oxidase/metabolism; Clorgyline/pharmacology; Deamination; Eye/enzymology; Male; Monoamine Oxidase/metabolism; Oxidoreductases Acting on CH-NH Group Donors/antagonists & inhibitors; Oxidoreductases Acting on CH-NH Group Donors/metabolism; Rats; Rats, Inbred Strains; Semicarbazides/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:AOC3

involved_in

GO:0007568: aging

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.