RAT:AMBP

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ambp (synonyms: Itil)
Protein Name(s)	Protein AMBP Alpha-1-microglobulin Inter-alpha-trypsin inhibitor light chain ITI-LC Bikunin HI-30 Trypstatin
External Links
UniProt	Q64240
EMBL	S87544 BC088166 J02600
PIR	S21089
RefSeq	NP_037033.1
SMR	Q64240
STRING	10116.ENSRNOP00000009248
MEROPS	I02.005
iPTMnet	Q64240
PhosphoSitePlus	Q64240
jPOST	Q64240
PaxDb	Q64240
PRIDE	Q64240
Ensembl	ENSRNOT00000009248
GeneID	25377
KEGG	rno:25377
UCSC	RGD:2102
CTD	259
RGD	2102
eggNOG	KOG4295 ENOG410XQNP
GeneTree	ENSGT00940000160109
HOGENOM	HOG000001572
InParanoid	Q64240
OMA	TCPWLKR
OrthoDB	1090505at2759
PhylomeDB	Q64240
TreeFam	TF351222
Reactome	R-RNO-2168880
PRO	PR:Q64240
Proteomes	UP000002494
Bgee	ENSRNOG00000006889
Genevisible	Q64240
GO	GO:0009986 GO:0005615 GO:0043231 GO:0005886 GO:0020037 GO:0019862 GO:0042803 GO:0004867 GO:0030163 GO:0018298
CDD	cd00109
Gene3D	2.40.128.20 4.10.410.10
InterPro	IPR002968 IPR029856 IPR012674 IPR002223 IPR036880 IPR022272 IPR000566 IPR020901
PANTHER	PTHR46676
Pfam	PF00014 PF00061
PRINTS	PR01215 PR00759
SMART	SM00131
SUPFAM	SSF50814 SSF57362
PROSITE	PS00280 PS50279 PS00213

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	F	Seeded From UniProt
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	F	Seeded From UniProt
enables	GO:0019862	IgA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	F	Seeded From UniProt
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	C	Seeded From UniProt
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:1371936^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
involved_in	GO:0030163	protein catabolic process	PMID:11307954^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
part_of	GO:0009986	cell surface	PMID:15533056^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:11307954^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:11307954^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
part_of	GO:0009986	cell surface	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002928167 RGD:2102	C	Seeded From UniProt
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002928167 UniProtKB:P02760	C	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002928167 RGD:2102	F	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	F	Seeded From UniProt
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	F	Seeded From UniProt
enables	GO:0019862	IgA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	F	Seeded From UniProt
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	C	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002223 InterPro:IPR036880	F	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F	Seeded From UniProt
involved_in	GO:0018298	protein-chromophore linkage	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0157	P	Seeded From UniProt
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P	Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	F	Seeded From UniProt
enables	GO:0020037	heme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	F	Seeded From UniProt
enables	GO:0019862	IgA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	F	Seeded From UniProt
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02760	C	Seeded From UniProt
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:1371936^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
involved_in	GO:0030163	protein catabolic process	PMID:11307954^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
part_of	GO:0009986	cell surface	PMID:15533056^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:11307954^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:11307954^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
part_of	GO:0009986	cell surface	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002928167 RGD:2102	C	Seeded From UniProt
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002928167 UniProtKB:P02760	C	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002928167 RGD:2102	F	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004867	P	Seeded From UniProt
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	F	Seeded From UniProt
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	F	Seeded From UniProt
enables	GO:0019862	IgA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	F	Seeded From UniProt
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02760 ensembl:ENSP00000265132	C	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002223 InterPro:IPR036880	F	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F	Seeded From UniProt
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F	Seeded From UniProt
involved_in	GO:0018298	protein-chromophore linkage	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0157	P	Seeded From UniProt
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
	GO:0050727		PMID:11058759^[5]	ECO:0000311				Fig. 2. Cartoon representation of a three-dimensional model of α1m. The figure is modified from [18].	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lindqvist, A et al. (1992) Rat alpha 1-microglobulin: co-expression in liver with the light chain of inter-alpha-trypsin inhibitor. Biochim. Biophys. Acta 1130 63-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kurata, A et al. (2000) Purification, characterization, and relation to bikunin of rat urinary trypsin inhibitors. J. Protein Chem. 19 693-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Grewal, JS et al. (2005) Oxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cells. Biochem. J. 387 609-16 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Akerström, B et al. (2000) alpha(1)-Microglobulin: a yellow-brown lipocalin. Biochim. Biophys. Acta 1482 172-84 PubMed GONUTS page

[PMID:1371936-1] 1.0 ^1.1 Lindqvist, A et al. (1992) Rat alpha 1-microglobulin: co-expression in liver with the light chain of inter-alpha-trypsin inhibitor. Biochim. Biophys. Acta 1130 63-7 PubMed GONUTS page

[PMID:11307954-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kurata, A et al. (2000) Purification, characterization, and relation to bikunin of rat urinary trypsin inhibitors. J. Protein Chem. 19 693-8 PubMed GONUTS page

[PMID:15533056-3] 3.0 ^3.1 Grewal, JS et al. (2005) Oxalate-inducible AMBP gene and its regulatory mechanism in renal tubular epithelial cells. Biochem. J. 387 609-16 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11058759-5] Akerström, B et al. (2000) alpha(1)-Microglobulin: a yellow-brown lipocalin. Biochim. Biophys. Acta 1482 172-84 PubMed GONUTS page

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RAT:AMBP

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