RAT:5HT1A

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Htr1a (synonyms: 5ht1a)
Protein Name(s)	5-hydroxytryptamine receptor 1A 5-HT-1A 5-HT1A Serotonin receptor 1A
External Links
UniProt	P19327
EMBL	J05276
PIR	JH0315
RefSeq	NP_036717.1
UniGene	Rn.44486
ProteinModelPortal	P19327
IntAct	P19327
STRING	10116.ENSRNOP00000013618
BindingDB	P19327
ChEMBL	CHEMBL273
GuidetoPHARMACOLOGY	1
iPTMnet	P19327
PhosphoSitePlus	P19327
PaxDb	P19327
PRIDE	P19327
GeneID	24473
KEGG	rno:24473
UCSC	RGD:2845
CTD	3350
RGD	2845
eggNOG	KOG3656 ENOG410XRW9
HOGENOM	HOG000239242
HOVERGEN	HBG106962
InParanoid	P19327
KO	K04153
PhylomeDB	P19327
PRO	PR:P19327
Proteomes	UP000002494
GO	GO:0043203 GO:0005887 GO:0016020 GO:0043025 GO:0008144 GO:0001965 GO:0004993 GO:0030594 GO:0051378 GO:0005102 GO:0007198 GO:0001662 GO:0008283 GO:0035640 GO:0097114 GO:0031117 GO:0042053 GO:0060259 GO:0046883 GO:0014062 GO:0042428 GO:0007210 GO:0042310
CDD	cd15330
InterPro	IPR000610 IPR002231 IPR000276 IPR017452
PANTHER	PTHR24247:SF20
Pfam	PF00001
PRINTS	PR00512 PR01101 PR00237
SMART	SM01381
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0014053	negative regulation of gamma-aminobutyric acid secretion	PMID:30217553^[1]	ECO:0000315			P		Figure 5 shows that when 5-HT 1a(8-OH-DPAT) is activated the up regulation of GABA secretion due to CB1 activation is blocked. 5-hydroxytryptamine receptor 1A, and 5-HT1A, Rattus norvegicus (Rat)	complete CACAO 13365
involved_in	GO:0042428	serotonin metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0035640	exploration behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:0014062	regulation of serotonin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08908	C		Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64264	P		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:10381597^[2]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:10381597^[2]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:10381597^[2]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(GO:0098982) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:10381597^[2]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(GO:0098982) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:10381597^[2]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:10381597^[2]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:18442977^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	PMID:11900812^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:8891585^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:8271204^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:2947981^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	PMID:18622042^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:18622042^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031117	positive regulation of microtubule depolymerization	PMID:18442977^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8891585^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:8891585^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:2947981^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	PMID:12149253^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	PMID:11927181^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	PMID:8271204^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:25485703^[11]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620713	F		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:12149253^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:8271204^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	PMID:16772521^[12]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2713 RGD:2714 RGD:2717 RGD:628732	F		Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002385064 RGD:2845 RGD:62388	F		Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P		Seeded From UniProt	complete
involved_in	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002385064 RGD:2845 UniProtKB:P08908	P		Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610 InterPro:IPR002231	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610 InterPro:IPR002231	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000610 InterPro:IPR002231	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
involved_in	GO:0046883	regulation of hormone secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000610	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Koyama, S et al. (1999) Presynaptic serotonergic inhibition of GABAergic synaptic transmission in mechanically dissociated rat basolateral amygdala neurons. J. Physiol. (Lond.) 518 ( Pt 2) 525-38 PubMed GONUTS page
↑ ^3.0 ^3.1 Yuen, EY et al. (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex. J. Biol. Chem. 283 17194-204 PubMed GONUTS page
↑ Voigt, JP et al. (2002) Role of 5-HT1A receptors in the control of food intake in obese Zucker rats of different ages. Pharmacol. Biochem. Behav. 72 403-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Dalpiaz, A et al. (1996) Binding thermodynamics of 5-HT1A receptor ligands. Eur. J. Pharmacol. 312 107-14 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Penington, NJ et al. (1993) Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat. J. Physiol. (Lond.) 469 387-405 PubMed GONUTS page
↑ ^7.0 ^7.1 Vergé, D et al. (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6 3474-82 PubMed GONUTS page
↑ ^8.0 ^8.1 Wedzony, K et al. (2008) A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. J. Physiol. Pharmacol. 59 229-38 PubMed GONUTS page
↑ ^9.0 ^9.1 Cai, X et al. (2002) Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons. J. Biol. Chem. 277 36553-62 PubMed GONUTS page
↑ Hensler, JG (2002) Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26 565-73 PubMed GONUTS page
↑ Borroto-Escuela, DO et al. (2015) Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochem. Biophys. Res. Commun. 456 489-93 PubMed GONUTS page
↑ Mannoury la Cour, C et al. (2006) Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mol. Pharmacol. 70 1013-21 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:30217553-1] Cruz-Martínez, AM et al. (2018) CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Eur Neuropsychopharmacol PubMed GONUTS page

[PMID:10381597-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Koyama, S et al. (1999) Presynaptic serotonergic inhibition of GABAergic synaptic transmission in mechanically dissociated rat basolateral amygdala neurons. J. Physiol. (Lond.) 518 ( Pt 2) 525-38 PubMed GONUTS page

[PMID:18442977-3] 3.0 ^3.1 Yuen, EY et al. (2008) Activation of 5-HT2A/C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex. J. Biol. Chem. 283 17194-204 PubMed GONUTS page

[PMID:11900812-4] Voigt, JP et al. (2002) Role of 5-HT1A receptors in the control of food intake in obese Zucker rats of different ages. Pharmacol. Biochem. Behav. 72 403-9 PubMed GONUTS page

[PMID:8891585-5] 5.0 ^5.1 ^5.2 Dalpiaz, A et al. (1996) Binding thermodynamics of 5-HT1A receptor ligands. Eur. J. Pharmacol. 312 107-14 PubMed GONUTS page

[PMID:8271204-6] 6.0 ^6.1 ^6.2 Penington, NJ et al. (1993) Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat. J. Physiol. (Lond.) 469 387-405 PubMed GONUTS page

[PMID:2947981-7] 7.0 ^7.1 Vergé, D et al. (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6 3474-82 PubMed GONUTS page

[PMID:18622042-8] 8.0 ^8.1 Wedzony, K et al. (2008) A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. J. Physiol. Pharmacol. 59 229-38 PubMed GONUTS page

[PMID:12149253-9] 9.0 ^9.1 Cai, X et al. (2002) Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons. J. Biol. Chem. 277 36553-62 PubMed GONUTS page

[PMID:11927181-10] Hensler, JG (2002) Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration. Neuropsychopharmacology 26 565-73 PubMed GONUTS page

[PMID:25485703-11] Borroto-Escuela, DO et al. (2015) Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochem. Biophys. Res. Commun. 456 489-93 PubMed GONUTS page

[PMID:16772521-12] Mannoury la Cour, C et al. (2006) Regional differences in the coupling of 5-hydroxytryptamine-1A receptors to G proteins in the rat brain. Mol. Pharmacol. 70 1013-21 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 ^13.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:5HT1A

Contents

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References

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