RABIT:LBP

Species (Taxon ID)	Oryctolagus cuniculus (Rabbit). (9986)
Gene Name(s)	LBP
Protein Name(s)	Lipopolysaccharide-binding protein LBP
External Links
UniProt	P17454
EMBL	M35534
PIR	B35843
UniGene	Ocu.2065
ProteinModelPortal	P17454
SMR	P17454
STRING	9986.ENSOCUP00000011712
eggNOG	KOG4160 ENOG410Z88E
HOGENOM	HOG000231250
HOVERGEN	HBG002797
InParanoid	P17454
Proteomes	UP000001811
GO	GO:0005615 GO:0001530 GO:0005102 GO:0006953 GO:0006968 GO:0050829 GO:0045087 GO:0006869 GO:0002281 GO:0008228 GO:0032760
InterPro	IPR017943 IPR030675 IPR032942 IPR030180 IPR001124 IPR017954 IPR017942
PANTHER	PTHR10504 PTHR10504:SF66
Pfam	PF01273 PF02886
PIRSF	PIRSF002417
SMART	SM00328 SM00329
SUPFAM	SSF55394
PROSITE	PS00400

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0045087	innate immune response	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0008228	opsonization	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0006968	cellular defense response	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0006953	acute-phase response	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0005102	signaling receptor binding	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
enables	GO:0001530	lipopolysaccharide binding	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	F	Seeded From UniProt
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180 InterPro:IPR030675	C	Seeded From UniProt
involved_in	GO:0006953	acute-phase response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	P	Seeded From UniProt
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001124 InterPro:IPR017942 InterPro:IPR017943 InterPro:IPR017954 InterPro:IPR030675	F	Seeded From UniProt
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	P	Seeded From UniProt
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	P	Seeded From UniProt
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P	Seeded From UniProt
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0045087	innate immune response	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0008228	opsonization	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0006968	cellular defense response	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
involved_in	GO:0006953	acute-phase response	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
part_of	GO:0005615	extracellular space	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0005102	signaling receptor binding	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:2402637^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt
enables	GO:0001530	lipopolysaccharide binding	PMID:2477488^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	F	Seeded From UniProt
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180 InterPro:IPR030675	C	Seeded From UniProt
involved_in	GO:0006953	acute-phase response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	P	Seeded From UniProt
enables	GO:0008289	lipid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001124 InterPro:IPR017942 InterPro:IPR017943 InterPro:IPR017954 InterPro:IPR030675	F	Seeded From UniProt
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	P	Seeded From UniProt
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030180	P	Seeded From UniProt
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0044	P	Seeded From UniProt
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt
	GO:0032760	positive regulation of tumor necrosis factor production	PMID:2402637^[1]	ECO:0007070			P	Figure 2 A shows cytolytic activity of TNF pooled from cell-free supernatants from cultures of peritoneal exudate macrophages (PEM) with and without LPS binding protein (LBP) after being stimulated with LPS from E. coli. Although this TNF is being isolated from media, indicating it might be secreted, it is more logical to assume that LBP plays a role in TNF production rather than in the process of its secretion. L929 cells were incubated with purified TNF from PEM cell-free media, stained with crystal violet, and analyzed using spectrophotometry.	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Schumann, RR et al. (1990) Structure and function of lipopolysaccharide binding protein. Science 249 1429-31 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Wright, SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170 1231-41 PubMed GONUTS page

[PMID:2402637-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Schumann, RR et al. (1990) Structure and function of lipopolysaccharide binding protein. Science 249 1429-31 PubMed GONUTS page

[PMID:2477488-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 Wright, SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170 1231-41 PubMed GONUTS page

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RABIT:LBP

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