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PSEAI:P72137
Contents
| Species (Taxon ID) | Pseudomonas aeruginosa. (287) | |
| Gene Name(s) | wzx (ECO:0000313 with EMBL:AAC45858.1) | |
| Protein Name(s) | O-antigen translocase (ECO:0000313 with EMBL:CDO82548.1)
ORF_11 Wzx (ECO:0000313 with EMBL:AAC45858.1) | |
| External Links | ||
| UniProt | P72137 | |
| EMBL | U50396 AF498410 AF498412 AF498413 AF498416 HG974234 | |
| PIR | C83251 | |
| RefSeq | NP_251843.1 | |
| ProteinModelPortal | P72137 | |
| STRING | 208964.PA3153 | |
| GeneID | 882590 | |
| KEGG | pae:PA3153 | |
| PseudoCAP | PA3153 | |
| OrthoDB | EOG6SV5B1 | |
| GO | GO:0009276 GO:0016020 GO:0006810 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0030171 |
voltage-gated proton channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0030171 |
voltage-gated proton channel activity |
ECO:0000314 |
F |
I- flux was shown to significantly increase (~200% at pH 6.5 compared to pH 7.5) when proteoliposome external pH was decreased in Fig 2 which indicates Wzx's the proton-dependent transporter activity. |
complete | |||||
|
involved_in |
GO:1902600 |
proton transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0098567 |
periplasmic side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043165 |
Gram-negative-bacterium-type cell outer membrane assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034203 |
glycolipid translocation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015774 |
polysaccharide transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
RefSeq:NP_461033.1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015299 |
solute:proton antiporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015297 |
antiporter activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009276 |
Gram-negative-bacterium-type cell wall |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009243 |
O antigen biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Islam, ST et al. (2013) Proton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membrane. MBio 4 e00678-13 PubMed GONUTS page
- ↑ 2.0 2.1 Islam, ST et al. (2010) Membrane topology mapping of the O-antigen flippase (Wzx), polymerase (Wzy), and ligase (WaaL) from Pseudomonas aeruginosa PAO1 reveals novel domain architectures. MBio 1 PubMed GONUTS page
- ↑ Islam, ST et al. (2012) A cationic lumen in the Wzx flippase mediates anionic O-antigen subunit translocation in Pseudomonas aeruginosa PAO1. Mol. Microbiol. 84 1165-76 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Burrows, LL & Lam, JS (1999) Effect of wzx (rfbX) mutations on A-band and B-band lipopolysaccharide biosynthesis in Pseudomonas aeruginosa O5. J. Bacteriol. 181 973-80 PubMed GONUTS page
- ↑ Liu, D et al. (1996) An O-antigen processing function for Wzx (RfbX): a promising candidate for O-unit flippase. J. Bacteriol. 178 2102-7 PubMed GONUTS page
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