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PSEAE:TOXA

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Species (Taxon ID) Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964)
Gene Name(s) eta
Protein Name(s) Exotoxin A

ETA NAD(+)--diphthamide ADP-ribosyltransferase PE

External Links
UniProt P11439
EMBL K01397
AE004091
PIR A30347
C83503
RefSeq NP_249839.1
PDB 1AER
1DMA
1IKP
1IKQ
1XK9
1ZM2
1ZM3
1ZM4
1ZM9
2ZIT
3B78
3B82
3B8H
PDBsum 1AER
1DMA
1IKP
1IKQ
1XK9
1ZM2
1ZM3
1ZM4
1ZM9
2ZIT
3B78
3B82
3B8H
ProteinModelPortal P11439
SMR P11439
STRING 208964.PA1148
TCDB 1.C.73.1.1
EnsemblBacteria AAG04537
GeneID 877850
KEGG pae:PA1148
PATRIC 19836616
PseudoCAP PA1148
HOGENOM HOG000081585
KO K11020
OMA HESNEMQ
OrthoDB EOG6ZPSVM
BioCyc MetaCyc:MONOMER-15587
SABIO-RK P11439
EvolutionaryTrace P11439
Proteomes UP000002438
GO GO:0047286
GO:0008152
Gene3D 2.60.120.200
3.90.1350.10
InterPro IPR013320
IPR015185
IPR015099
IPR015186
Pfam PF09101
PF09009
PF09102
SUPFAM SSF49899
SSF56864

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0047286

NAD+-diphthamide ADP-ribosyltransferase activity

PMID:2170123[1]

ECO:0000314

F

Figure 3: ADP-ribosylation activity of exotoxin A with NAD+ after 30 minutes.

complete
CACAO 4212

GO:0031640

killing of cells of other organism

PMID:21567317[2]

ECO:0000314

P

Figure 3.

complete
CACAO 4389

enables

GO:0047286

NAD+-diphthamide ADP-ribosyltransferase activity

PMID:2170123[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0090729

P

Seeded From UniProt

complete

enables

GO:0047286

NAD+-diphthamide ADP-ribosyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015099

F

Seeded From UniProt

complete

enables

GO:0047286

NAD+-diphthamide ADP-ribosyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.2.36

F

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

enables

GO:0090729

toxin activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0800

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bourdenet, S et al. (1990) Biochemical and immunochemical studies of proteolytic fragments of exotoxin A from Pseudomonas aeruginosa. Eur. J. Biochem. 192 379-85 PubMed GONUTS page
  2. Massey, S et al. (2011) A cell-based fluorescent assay to detect the activity of Shiga toxin and other toxins that inhibit protein synthesis. Methods Mol. Biol. 739 49-59 PubMed GONUTS page