GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PSEAE:MEXR
Contents
| Species (Taxon ID) | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964) | |
| Gene Name(s) | mexR | |
| Protein Name(s) | Multidrug resistance operon repressor | |
| External Links | ||
| UniProt | P52003 | |
| EMBL | U23763 AY190292 AY190294 AY190293 AY190295 AY899299 AY899300 AY899301 AE004091 | |
| PIR | C83593 | |
| RefSeq | NP_249115.1 | |
| PDB | 1LNW 3ECH 3MEX | |
| PDBsum | 1LNW 3ECH 3MEX | |
| ProteinModelPortal | P52003 | |
| SMR | P52003 | |
| DIP | DIP-46302N | |
| IntAct | P52003 | |
| MINT | MINT-8011533 | |
| STRING | 208964.PA0424 | |
| DNASU | 877857 | |
| EnsemblBacteria | AAG03813 | |
| GeneID | 877857 | |
| KEGG | pae:PA0424 | |
| PATRIC | 19835090 | |
| PseudoCAP | PA0424 | |
| eggNOG | COG1846 | |
| InParanoid | P52003 | |
| KO | K18131 | |
| OMA | WQESERI | |
| OrthoDB | EOG699762 | |
| PhylomeDB | P52003 | |
| EvolutionaryTrace | P52003 | |
| Proteomes | UP000002438 | |
| GO | GO:0005622 GO:0042802 GO:0003700 GO:0044212 GO:0050709 GO:0045892 GO:0034763 GO:0006351 | |
| Gene3D | 1.10.10.10 | |
| InterPro | IPR000835 IPR011991 | |
| Pfam | PF01047 | |
| PRINTS | PR00598 | |
| SMART | SM00347 | |
| PROSITE | PS50995 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000315 |
F |
Table 2. shows twofold increase in mexA-lacZ expression in mutant lacking mexR |
complete | |||||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0001808 |
reverse transcription polymerase chain reaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005631 |
DNAse footprinting evidence used in manual assertion |
RefSeq:NC_002516.2 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0005631 |
DNAse footprinting evidence used in manual assertion |
RefSeq:NC_002516.2 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0005631 |
DNAse footprinting evidence used in manual assertion |
RefSeq:NC_002516.2 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10603 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002448924 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050709 |
negative regulation of protein secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034763 |
negative regulation of transmembrane transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Poole, K et al. (1996) Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression. Antimicrob. Agents Chemother. 40 2021-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Evans, K et al. (2001) MexR repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa: identification of MexR binding sites in the mexA-mexR intergenic region. J. Bacteriol. 183 807-12 PubMed GONUTS page
- ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Srikumar, R et al. (2000) Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-oprM multidrug efflux system of Pseudomonas aeruginosa. J. Bacteriol. 182 1410-4 PubMed GONUTS page
- ↑ Chen, H et al. (2010) Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR. EMBO Rep. 11 685-90 PubMed GONUTS page
b
d
n
p
