PSEAE:FUR

Species (Taxon ID)	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964)
Gene Name(s)	fur
Protein Name(s)	Ferric uptake regulation protein Ferric uptake regulator
External Links
UniProt	Q03456
EMBL	L00604 AF050676 AE004091
PIR	A40622
RefSeq	NP_253452.1
PDB	1MZB
PDBsum	1MZB
ProteinModelPortal	Q03456
SMR	Q03456
STRING	208964.PA4764
World-2DPAGE	0008:Q03456
DNASU	881780
EnsemblBacteria	AAG08150
GeneID	881780
KEGG	pae:PA4764
PATRIC	19844317
PseudoCAP	PA4764
eggNOG	COG0735
HOGENOM	HOG000014144
InParanoid	Q03456
KO	K03711
OMA	YGVCTND
OrthoDB	EOG6J48SS
PhylomeDB	Q03456
EvolutionaryTrace	Q03456
Proteomes	UP000002438
GO	GO:0005737 GO:0008198 GO:0003700 GO:0044212 GO:0051350 GO:1900705 GO:2000470 GO:1901668 GO:0019290 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR002481 IPR011991
Pfam	PF01475

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0019290	siderophore biosynthetic process	PMID:8478325^[1]	ECO:0000315			P	Table 3 shows that the fur mutant constitutively produces pyoverdin. When the mutant is complemented with the wild-type gene it no longer constitutively produces pyoverdin.	complete CACAO 7932
involved_in	GO:0019290	siderophore biosynthetic process	PMID:8478325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21546589^[2]	ECO:0005660	quantitative polymerase chain reaction evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9045799^[3]	ECO:0005657	primer extension assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15210934^[4]	ECO:0005653	northern assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:8633080^[5]	ECO:0000288	RNA protection assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10658665^[6]	ECO:0000288	RNA protection assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:8633080^[5]	ECO:0005634	genomic systematic evolution of ligands by exponential amplification evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:21546589^[2]	ECO:0005633	ferric uptake regulator titration assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:9045799^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:8633080^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:10658665^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:9045799^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:8633080^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:15210934^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:8633080^[5]	ECO:0005634	genomic systematic evolution of ligands by exponential amplification evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:21546589^[2]	ECO:0005633	ferric uptake regulator titration assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:9045799^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:8633080^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:10658665^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:9045799^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:8633080^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0001217	DNA-binding transcription repressor activity	PMID:15210934^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:8633080^[5]	ECO:0005634	genomic systematic evolution of ligands by exponential amplification evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21546589^[2]	ECO:0005633	ferric uptake regulator titration assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:9045799^[3]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:8633080^[5]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:10658665^[6]	ECO:0005631	DNAse footprinting evidence used in manual assertion	RefSeq:NC_002516.2	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:9045799^[3]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:8633080^[5]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:15210934^[4]	ECO:0001807	electrophoretic mobility shift assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1900705	negative regulation of siderophore biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112483 UniProtKB:Q03456	P	Seeded From UniProt	complete
involved_in	GO:1900376	regulation of secondary metabolite biosynthetic process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q9HT74	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112386 UniProtKB:P0A0S8 UniProtKB:P0C6C8 UniProtKB:P54479 UniProtKB:P54574 UniProtKB:P74739 UniProtKB:P9WN85 UniProtKB:Q03456 UniProtKB:Q7BR72 UniProtKB:Q7CQY3 UniProtKB:Q8EFN3 UniProtKB:Q8PAL3 UniProtKB:Q8Y5U9 UniProtKB:Q9HT74 UniProtKB:Q9L2H5	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q03456	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112386 UniProtKB:P9WN85	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10359 PANTHER:PTN002112441	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:P9WN87	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002112386 UniProtKB:Q9HT74	F	Seeded From UniProt	complete
involved_in	GO:2000470	positive regulation of peroxidase activity	PMID:8763923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901668	regulation of superoxide dismutase activity	PMID:8763923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900705	negative regulation of siderophore biosynthetic process	PMID:8885270^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051350	negative regulation of lyase activity	PMID:9045799^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:8522528^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002481	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002481	P	Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	PMID:8522528^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Prince, RW et al. (1993) Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. J. Bacteriol. 175 2589-98 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Elias, S et al. (2011) FvbA is required for vibriobactin utilization in Pseudomonas aeruginosa. Microbiology (Reading, Engl.) 157 2172-80 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Hassett, DJ et al. (1997) An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels. J. Bacteriol. 179 1452-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wilderman, PJ et al. (2004) Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis. Proc. Natl. Acad. Sci. U.S.A. 101 9792-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Ochsner, UA & Vasil, ML (1996) Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes. Proc. Natl. Acad. Sci. U.S.A. 93 4409-14 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Ochsner, UA et al. (2000) Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa. Microbiology (Reading, Engl.) 146 ( Pt 1) 185-98 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 Hassett, DJ et al. (1996) Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities. J. Bacteriol. 178 3996-4003 PubMed GONUTS page
↑ Barton, HA et al. (1996) Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments. Mol. Microbiol. 21 1001-17 PubMed GONUTS page
↑ ^10.0 ^10.1 Ochsner, UA et al. (1995) Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters. J. Bacteriol. 177 7194-201 PubMed GONUTS page

[PMID:8478325-1] 1.0 ^1.1 Prince, RW et al. (1993) Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene. J. Bacteriol. 175 2589-98 PubMed GONUTS page

[PMID:21546589-2] 2.0 ^2.1 ^2.2 ^2.3 Elias, S et al. (2011) FvbA is required for vibriobactin utilization in Pseudomonas aeruginosa. Microbiology (Reading, Engl.) 157 2172-80 PubMed GONUTS page

[PMID:9045799-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Hassett, DJ et al. (1997) An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: fur mutants produce elevated alginate levels. J. Bacteriol. 179 1452-9 PubMed GONUTS page

[PMID:15210934-4] 4.0 ^4.1 ^4.2 ^4.3 Wilderman, PJ et al. (2004) Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis. Proc. Natl. Acad. Sci. U.S.A. 101 9792-7 PubMed GONUTS page

[PMID:8633080-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Ochsner, UA & Vasil, ML (1996) Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes. Proc. Natl. Acad. Sci. U.S.A. 93 4409-14 PubMed GONUTS page

[PMID:10658665-6] 6.0 ^6.1 ^6.2 ^6.3 Ochsner, UA et al. (2000) Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa. Microbiology (Reading, Engl.) 146 ( Pt 1) 185-98 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8763923-8] 8.0 ^8.1 Hassett, DJ et al. (1996) Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities. J. Bacteriol. 178 3996-4003 PubMed GONUTS page

[PMID:8885270-9] Barton, HA et al. (1996) Ferric uptake regulator mutants of Pseudomonas aeruginosa with distinct alterations in the iron-dependent repression of exotoxin A and siderophores in aerobic and microaerobic environments. Mol. Microbiol. 21 1001-17 PubMed GONUTS page

[PMID:8522528-10] 10.0 ^10.1 Ochsner, UA et al. (1995) Role of the ferric uptake regulator of Pseudomonas aeruginosa in the regulation of siderophores and exotoxin A expression: purification and activity on iron-regulated promoters. J. Bacteriol. 177 7194-201 PubMed GONUTS page

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PSEAE:FUR

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