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PSEAE:EXSA
Contents
| Species (Taxon ID) | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964) | |
| Gene Name(s) | exsA | |
| Protein Name(s) | Exoenzyme S synthesis regulatory protein ExsA | |
| External Links | ||
| UniProt | P26993 | |
| EMBL | M64975 AE004091 | |
| PIR | A83430 C41047 | |
| RefSeq | NP_250404.1 | |
| ProteinModelPortal | P26993 | |
| SMR | P26993 | |
| IntAct | P26993 | |
| MINT | MINT-8405738 | |
| STRING | 208964.PA1713 | |
| BindingDB | P26993 | |
| ChEMBL | CHEMBL1075205 | |
| DNASU | 879712 | |
| EnsemblBacteria | AAG05102 | |
| GeneID | 879712 | |
| KEGG | pae:PA1713 | |
| PATRIC | 19837779 | |
| PseudoCAP | PA1713 | |
| eggNOG | COG2207 | |
| HOGENOM | HOG000247159 | |
| InParanoid | P26993 | |
| OMA | CAHENRE | |
| OrthoDB | EOG6SZ1FM | |
| PhylomeDB | P26993 | |
| Proteomes | UP000002438 | |
| GO | GO:0043565 GO:0003700 GO:0044212 GO:0050709 GO:0006355 GO:0006351 | |
| Gene3D | 1.10.10.60 2.60.120.10 | |
| InterPro | IPR009057 IPR018060 IPR018062 IPR014710 IPR020449 | |
| Pfam | PF12833 | |
| PRINTS | PR00032 | |
| SMART | SM00342 | |
| SUPFAM | SSF46689 | |
| PROSITE | PS00041 PS01124 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000144 |
positive regulation of DNA-templated transcription, initiation |
ECO:0000314 |
P |
Figure 8 shows that the binding site is required for transcription activation, but the paper already established activation via IDA in Fig 7 |
complete | |||||
|
involved_in |
GO:2000144 |
positive regulation of DNA-templated transcription, initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0005631 |
DNAse footprinting evidence used in manual assertion |
RefSeq:NC_002516.2 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005631 |
DNAse footprinting evidence used in manual assertion |
RefSeq:NC_002516.2 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001216 |
DNA-binding transcription activator activity |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001216 |
DNA-binding transcription activator activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050709 |
negative regulation of protein secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 King, JM et al. (2013) ExsA and LcrF recognize similar consensus binding sites, but differences in their oligomeric state influence interactions with promoter DNA. J. Bacteriol. 195 5639-50 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Brutinel, ED et al. (2009) Functional domains of ExsA, the transcriptional activator of the Pseudomonas aeruginosa type III secretion system. J. Bacteriol. 191 3811-21 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Brutinel, ED et al. (2008) Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 68 657-71 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Brutinel, ED et al. (2012) The distal ExsA-binding site in Pseudomonas aeruginosa type III secretion system promoters is the primary determinant for promoter-specific properties. J. Bacteriol. 194 2564-72 PubMed GONUTS page
- ↑ Frank, DW & Iglewski, BH (1991) Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. J. Bacteriol. 173 6460-8 PubMed GONUTS page
- ↑ 6.0 6.1 Hovey, AK & Frank, DW (1995) Analyses of the DNA-binding and transcriptional activation properties of ExsA, the transcriptional activator of the Pseudomonas aeruginosa exoenzyme S regulon. J. Bacteriol. 177 4427-36 PubMed GONUTS page
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