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PMID:8185948
| Citation |
Asenjo, AB, Rim, J and Oprian, DD (1994) Molecular determinants of human red/green color discrimination. Neuron 12:1131-8 |
|---|---|
| Abstract |
The human red and green color vision pigments are identical at all but 15 of their 364 amino acids, and yet their absorption maxima differ by 31 nm. In an extensive mutagenesis study, including a set of 28 chimeric proteins modeled after pigments in the color-deficient human population and an additional 30 single and multiple point mutants, the spectral difference between these 2 pigments is shown to be determined by 7 and only 7 amino acid residues. In going from the red pigment to the green pigment, the 7 residues are Ser116-->Tyr, Ser180-->Ala, Ile230-->Thr, Ala233-->Ser, Tyr277-->Phe, Thr285-->Ala, and Tyr309-->Phe. |
| Links | |
| Keywords |
Amino Acid Sequence; Color; Color Perception/physiology; Discrimination (Psychology)/physiology; Exons; Genes, Synthetic; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Structure, Secondary; Recombinant Fusion Proteins/biosynthesis; Recombinant Fusion Proteins/chemistry; Retinal Pigments/biosynthesis; Retinal Pigments/chemistry; Retinal Pigments/genetics; Spectrophotometry |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0009881: photoreceptor activity |
ECO:0000315: |
F |
Figure 4, shows the absorbance spectrum of the gene product and the spectra of common mutants that affect the protein's light absorbing capabilities. |
complete | ||||
|
enables |
GO:0009881: photoreceptor activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0009881: photoreceptor activity |
ECO:0000315: |
F |
Figure 3, shows the absorbance spectra of the gene product and the resulting spectra that occur from mutations in the gene. |
complete | ||||
|
enables |
GO:0009881: photoreceptor activity |
ECO:0000315: mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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