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HUMAN:OPSR

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) OPN1LW (synonyms: RCP)
Protein Name(s) Long-wave-sensitive opsin 1

Red cone photoreceptor pigment Red-sensitive opsin ROP

External Links
UniProt P04000
EMBL M13305
M13300
M13301
M13302
M13303
M13304
Z68193
CCDS CCDS14742.1
PIR A03157
UniGene Hs.247787
Hs.592247
PDB 1KPX
PDBsum 1KPX
ProteinModelPortal P04000
SMR P04000
BioGrid 111889
STRING 9606.ENSP00000358967
ChEMBL CHEMBL1949482
TCDB 9.A.14.1.1
DMDM 129219
PaxDb P04000
PRIDE P04000
DNASU 5956
Ensembl ENST00000369951
UCSC uc004fjz.4
GeneCards GC0XP153409
GeneReviews OPN1LW
H-InvDB HIX0203334
HGNC HGNC:9936
MIM 300822
303700
303900
neXtProt NX_P04000
Orphanet 16
1872
319691
PharmGKB PA31936
eggNOG NOG240324
HOGENOM HOG000253932
HOVERGEN HBG107442
InParanoid P04000
OMA TSAWMIF
OrthoDB EOG72NRQJ
PhylomeDB P04000
TreeFam TF324998
Reactome REACT_160083
REACT_160130
REACT_18426
REACT_19231
ChiTaRS OPN1LW
NextBio 23196
PRO PR:P04000
Proteomes UP000005640
Bgee P04000
CleanEx HS_OPN1LW
Genevestigator P04000
GO GO:0005887
GO:0042622
GO:0004930
GO:0009881
GO:0007603
GO:0032467
GO:0018298
GO:0001523
GO:0007165
GO:0007601
InterPro IPR000276
IPR017452
IPR001760
IPR000378
IPR027430
Pfam PF00001
PRINTS PR00237
PR00238
PR00575
PROSITE PS00237
PS50262
PS00238

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009881

photoreceptor activity

PMID:8185948[1]

ECO:0000315

F

Figure 3, shows the absorbance spectra of the gene product and the resulting spectra that occur from mutations in the gene.

complete
CACAO 4249

enables

GO:0009881

photoreceptor activity

PMID:8185948[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0032467

positive regulation of cytokinesis

PMID:22888021[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071482

cellular response to light stimulus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002940
MGI:MGI:97914
PANTHER:PTN000662115
UniProtKB:D0E2W5
UniProtKB:F1NEY8

P

Seeded From UniProt

complete

enables

GO:0008020

G protein-coupled photoreceptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002940
FB:FBgn0003249
FB:FBgn0003250
FB:FBgn0014019
FB:FBgn0019940
MGI:MGI:1353425
PANTHER:PTN000662115
RGD:621701
UniProtKB:D0E2W5
UniProtKB:F1NEY2
UniProtKB:F1NEY8
UniProtKB:P02699
UniProtKB:Q9UHM6

F

Seeded From UniProt

complete

involved_in

GO:0007602

phototransduction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002940
FB:FBgn0014019
FB:FBgn0019940
MGI:MGI:1353425
MGI:MGI:97914
PANTHER:PTN000662115
RGD:621701
UniProtKB:F1RAF0
UniProtKB:Q9UHM6
ZFIN:ZDB-GENE-040724-51
ZFIN:ZDB-GENE-061201-30
ZFIN:ZDB-GENE-081105-91

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662115
UniProtKB:P08100
ZFIN:ZDB-GENE-070111-2
ZFIN:ZDB-GENE-080415-3
ZFIN:ZDB-GENE-110622-1

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1929473
PANTHER:PTN000662115
UniProtKB:P02699

C

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097692
MGI:MGI:97914
MGI:MGI:99438
PANTHER:PTN000662150
RGD:3573
RGD:620978
RGD:621033
UniProtKB:F1P3Y2
UniProtKB:P08100
UniProtKB:P22328
UniProtKB:P22329
ZFIN:ZDB-GENE-990604-42

C

Seeded From UniProt

complete

involved_in

GO:0009584

detection of visible light

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008020

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000378
InterPro:IPR001760

P

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000378
InterPro:IPR001760

P

Seeded From UniProt

complete

involved_in

GO:0007602

phototransduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000378

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR000378
InterPro:IPR001760
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0009881

photoreceptor activity

PMID:9860863[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

PMID:7643192[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:2937147[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9860863[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097381

photoreceptor disc membrane

Reactome:R-HSA-8982640
Reactome:R-HSA-8982637
Reactome:R-HSA-420883
Reactome:R-HSA-419841
Reactome:R-HSA-2471660
Reactome:R-HSA-2471641
Reactome:R-HSA-2466834
Reactome:R-HSA-2466822
Reactome:R-HSA-2466706
Reactome:R-HSA-2466085
Reactome:R-HSA-2465924
Reactome:R-HSA-2465917

ECO:0000304

author statement supported by traceable reference used in manual assertion












C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001523

retinoid metabolic process

Reactome:R-HSA-2187335

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0018298

protein-chromophore linkage

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0157

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

involved_in

GO:0007601

visual perception

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

enables

GO:0009881

photoreceptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0600

F

Seeded From UniProt

complete

involved_in

GO:0007602

phototransduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0681

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Asenjo, AB et al. (1994) Molecular determinants of human red/green color discrimination. Neuron 12 1131-8 PubMed GONUTS page
  2. ↑ Zhang, X et al. (2012) G protein-coupled receptors participate in cytokinesis. Cytoskeleton (Hoboken) 69 810-8 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Nakayama, TA et al. (1998) Mutagenesis studies of human red opsin: trp-281 is essential for proper folding and protein-retinal interactions. Biochemistry 37 17487-94 PubMed GONUTS page
  5. ↑ Li, ZY et al. (1995) Rod photoreceptor neurite sprouting in retinitis pigmentosa. J. Neurosci. 15 5429-38 PubMed GONUTS page
  6. ↑ Nathans, J et al. (1986) Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science 232 193-202 PubMed GONUTS page
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