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PMID:6382022
| Citation |
Dull, TJ, Gray, A, Hayflick, JS and Ullrich, A Insulin-like growth factor II precursor gene organization in relation to insulin gene family. Nature 310:777-81 |
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| Abstract |
The insulin gene family, comprised of insulin, relaxin, insulin-like growth factors I and II (IGF-I and IGF-II) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth (see ref. 4 for review). IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. The primary structures of both human IGFs have been determined and are closely related. A polypeptide highly homologous to human IGF-II is secreted by the rat liver cell line, BRL-3A. As this polypeptide, termed multiplication stimulating activity (MSA), differs from human IGF-II by only five amino acid residues, MSA probably represents the rat IGF-II protein. Using molecular cloning techniques, we have isolated cDNA and chromosomal genes coding for the MSA and human IGF-II precursors, respectively. Our data, presented here, indicate that both MSA and human IGF-II are synthesized initially as larger precursor molecules. The deduced preprohormones both have molecular weights (MWs) of 20,100 and contain C-terminal propeptides of 89 amino acid residues, which we have named E-peptides. The organization of the IGF-II precursor gene is discussed in relation to that of other insulin gene family members. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA/isolation & purification; Genes; Humans; Insulin/genetics; Insulin-Like Growth Factor II; Mice; Nucleic Acid Hybridization; Protein Biosynthesis; Protein Precursors/genetics; Rats; Rats, Inbred BUF; Somatomedins/genetics; Structure-Activity Relationship |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
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involved_in |
GO:0007275: multicellular organism development |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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