HUMAN:IGF2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IGF2
Protein Name(s)	Insulin-like growth factor II IGF-II Somatomedin-A Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
External Links
UniProt	P01344
EMBL	X03562 X00910 J03242 X03425 X03426 X03427 M17426 M29645 M17863 S77035 DQ104203 HM481219 AF217977 BT007013 AF517226 AC132217 AK126688 CH471158 BC000531 X07868 X06159 X06160 X06161 M22373
CCDS	CCDS44517.1 CCDS7728.1
PIR	B23614 I67610 S02423
RefSeq	NP_000603.1 NP_001007140.2 NP_001121070.1 NP_001278790.1 NP_001278791.1
UniGene	Hs.272259
PDB	1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
PDBsum	1GF2 1IGL 2L29 2V5P 3E4Z 3KR3
ProteinModelPortal	P01344
SMR	P01344
BioGrid	109702
DIP	DIP-29508N
IntAct	P01344
MINT	MINT-6380943
STRING	9606.ENSP00000338297
PhosphoSite	P01344
DMDM	124255
MaxQB	P01344
PaxDb	P01344
PRIDE	P01344
DNASU	3481
Ensembl	ENST00000300632 ENST00000381389 ENST00000381392 ENST00000381395 ENST00000381406 ENST00000416167 ENST00000418738 ENST00000434045
GeneID	3481
KEGG	hsa:3481
UCSC	uc001lvg.3
CTD	3481
GeneCards	GC11M002152
GeneReviews	IGF2
H-InvDB	HIX0128667
HGNC	HGNC:5466
HPA	CAB024999 HPA007993
MIM	147470 180860
neXtProt	NX_P01344
Orphanet	231117 2128 231144 231140
PharmGKB	PA29699
eggNOG	NOG44017
GeneTree	ENSGT00530000063856
HOVERGEN	HBG006137
InParanoid	P01344
KO	K13769
OMA	FFQYDTW
OrthoDB	EOG7TF7CG
PhylomeDB	P01344
TreeFam	TF332820
Reactome	REACT_150139 REACT_150203 REACT_150359 REACT_15428
SignaLink	P01344
ChiTaRS	IGF2
EvolutionaryTrace	P01344
GeneWiki	Insulin-like_growth_factor_2
GenomeRNAi	3481
NextBio	13686
PMAP-CutDB	P01344
PRO	PR:P01344
Proteomes	UP000005640
Bgee	P01344
CleanEx	HS_IGF2
ExpressionAtlas	P01344
Genevestigator	P01344
GO	GO:0005576 GO:0005615 GO:0070062 GO:0005886 GO:0031093 GO:0008083 GO:0005158 GO:0005159 GO:0043539 GO:0030546 GO:0007596 GO:0044267 GO:0071260 GO:0031017 GO:0007565 GO:0006006 GO:0008286 GO:0038028 GO:0007613 GO:0007275 GO:0009887 GO:0001649 GO:0030168 GO:0002576 GO:0042104 GO:0043085 GO:0008284 GO:2000467 GO:0045725 GO:0046628 GO:0043410 GO:0045840 GO:0050731 GO:0051897 GO:0001934 GO:0090031 GO:0045944 GO:0006349 GO:0006355 GO:0042493 GO:0032355 GO:0045471 GO:0035094 GO:0031667 GO:0009314 GO:0001501 GO:0051146
Gene3D	1.10.100.10
InterPro	IPR022334 IPR013576 IPR016179 IPR022350 IPR022353 IPR022352
Pfam	PF08365 PF00049
PRINTS	PR02002 PR02006 PR00276
ProDom	PD005188
SMART	SM00078
SUPFAM	SSF56994
PROSITE	PS00262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:28873464^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:28873464^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0051147	regulation of muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0031056	regulation of histone modification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:2967174^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0001911)	Seeded From UniProt	complete
involved_in	GO:2000467	positive regulation of glycogen (starch) synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:11500939^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	PMID:11500939^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	PMID:11500939^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:11500939^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	PMID:15694994^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:11500939^[3]	ECO:0000305	curator inference used in manual assertion	GO:0045840	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:11500939^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12881524^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:12138094^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0060669	embryonic placenta morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09535	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043539	P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0043539	P		Seeded From UniProt	complete
involved_in	GO:2000467	positive regulation of glycogen (starch) synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0060669	embryonic placenta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0051147	regulation of muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	F		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	F		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0031056	regulation of histone modification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0031017	exocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	C		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09535 ensembl:ENSMUSP00000114076	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016179 InterPro:IPR022350 InterPro:IPR022352	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016179	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022334 InterPro:IPR022350	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022334 InterPro:IPR022350	F		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:1845984^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:6382022^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006349	regulation of gene expression by genetic imprinting	PMID:8968759^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:1845984^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:8298652^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5686072 Reactome:R-HSA-481007 Reactome:R-HSA-381545 Reactome:R-HSA-381543 Reactome:R-HSA-381537 Reactome:R-HSA-381518 Reactome:R-HSA-381503 Reactome:R-HSA-381500 Reactome:R-HSA-381496 Reactome:R-HSA-381487 Reactome:R-HSA-381466 Reactome:R-HSA-381461 Reactome:R-HSA-381446 Reactome:R-HSA-381435 Reactome:R-HSA-381412 Reactome:R-HSA-2428930 Reactome:R-HSA-2428926 Reactome:R-HSA-2428922 Reactome:R-HSA-2404200 Reactome:R-HSA-2404199 Reactome:R-HSA-2404195 Reactome:R-HSA-2404193	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0892	P		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Cedano Prieto, DM et al. (2017) Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PLoS ONE 12 e0184285 PubMed GONUTS page
↑ Dehoff, MH et al. (1988) Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue. Endocrinology 122 2412-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Scalia, P et al. (2001) Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A. J. Cell. Biochem. 82 610-8 PubMed GONUTS page
↑ Hettmer, S et al. (2005) Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells. Hum. Immunol. 66 95-103 PubMed GONUTS page
↑ Pandini, G et al. (2003) Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A. J. Biol. Chem. 278 42178-89 PubMed GONUTS page
↑ Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page
↑ ^7.0 ^7.1 Bürgisser, DM et al. (1991) Mutants of human insulin-like growth factor II with altered affinities for the type 1 and type 2 insulin-like growth factor receptor. J. Biol. Chem. 266 1029-33 PubMed GONUTS page
↑ Dull, TJ et al. () Insulin-like growth factor II precursor gene organization in relation to insulin gene family. Nature 310 777-81 PubMed GONUTS page
↑ Brown, KW et al. (1996) Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway. Hum. Mol. Genet. 5 2027-32 PubMed GONUTS page
↑ Ogawa, O et al. (1993) Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism. Nat. Genet. 5 408-12 PubMed GONUTS page

[PMID:28873464-1] 1.0 ^1.1 Cedano Prieto, DM et al. (2017) Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling. PLoS ONE 12 e0184285 PubMed GONUTS page

[PMID:2967174-2] Dehoff, MH et al. (1988) Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue. Endocrinology 122 2412-7 PubMed GONUTS page

[PMID:11500939-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Scalia, P et al. (2001) Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A. J. Cell. Biochem. 82 610-8 PubMed GONUTS page

[PMID:15694994-4] Hettmer, S et al. (2005) Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells. Hum. Immunol. 66 95-103 PubMed GONUTS page

[PMID:12881524-5] Pandini, G et al. (2003) Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A. J. Biol. Chem. 278 42178-89 PubMed GONUTS page

[PMID:12138094-6] Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page

[PMID:1845984-7] 7.0 ^7.1 Bürgisser, DM et al. (1991) Mutants of human insulin-like growth factor II with altered affinities for the type 1 and type 2 insulin-like growth factor receptor. J. Biol. Chem. 266 1029-33 PubMed GONUTS page

[PMID:6382022-8] Dull, TJ et al. () Insulin-like growth factor II precursor gene organization in relation to insulin gene family. Nature 310 777-81 PubMed GONUTS page

[PMID:8968759-9] Brown, KW et al. (1996) Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway. Hum. Mol. Genet. 5 2027-32 PubMed GONUTS page

[PMID:8298652-10] Ogawa, O et al. (1993) Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism. Nat. Genet. 5 408-12 PubMed GONUTS page

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HUMAN:IGF2

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