GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:30837651
| Citation |
Gordon, SM, Neufeld, EB, Yang, Z, Pryor, M, Freeman, LA, Fan, X, Kullo, IJ, Biesecker, LG and Remaley, AT (2019) DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass. Sci Rep 9:3597 |
|---|---|
| Abstract |
Regulation of lipid absorption by enterocytes can influence metabolic status in humans and contribute to obesity and related complications. The intracellular steps of chylomicron biogenesis and transport from the Endoplasmic Reticulum (ER) to the Golgi complex have been described, but the mechanisms for post-Golgi transport and secretion of chylomicrons have not been identified. Using a newly generated Dennd5b mouse, we demonstrate an essential role for this gene in Golgi to plasma membrane transport of chylomicron secretory vesicles. In mice, loss of Dennd5b results in resistance to western diet induced obesity, changes in plasma lipids, and reduced aortic atherosclerosis. In humans, two independent exome sequencing studies reveal that a common DENND5B variant, p.(R52K), is correlated with body mass index. These studies establish an important role for DENND5B in post-Golgi chylomicron secretion and a subsequent influence on body composition and peripheral lipoprotein metabolism. |
| Links |
PubMed PMC6401118 Online version:10.1038/s41598-019-40296-0 |
| Keywords |
|
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:1905885: positive regulation of triglyceride transport |
ECO:0005601: immunofluorescence confocal microscopy evidence used in manual assertion |
P |
In Figure 2G, there is a significant absence of apoB in dennd5b -/- mice, a protein required for enterocyte absorption of triglycerides (lipids), compared to dennd5b+/+ mice. |
complete | ||||
Notes
See also
References
See Help:References for how to manage references in GONUTS.
