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PMID:28012893
| Citation |
Ahmad, S, Jan, AT, Baig, MH, Lee, EJ and Choi, I (2017) Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program. Life Sci. 172:55-63 |
|---|---|
| Abstract |
Skeletal muscle development involves interactions between intracellular and extracellular factors that act in concert to regulate the myogenic process. Matrix gla protein (MGP), a well-known inhibitor of calcification in soft tissues, has been reported to be highly up-regulated during myogenesis. Our interest in the regulation of muscle satellite cells (MSCs) by extracellular matrix (ECM) led us to investigate the effects of MGP during the progression of myogenesis. |
| Links |
PubMed Online version:10.1016/j.lfs.2016.12.011 |
| Keywords |
Animals; Calcium Channels, L-Type/metabolism; Calcium-Binding Proteins/physiology; Extracellular Matrix Proteins/physiology; Mice; Muscle, Skeletal/metabolism; Myostatin/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048644: muscle organ morphogenesis |
ECO:0000315: |
P |
MGPkd cells show reduced MSTN expression, a negative regulator of muscle development, using both RT-PCR (mRNA) and Western Blot (protein). (Figure 3D) |
complete | ||||
Notes
See also
References
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