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Ahmad, S, Jan, AT, Baig, MH, Lee, EJ and Choi, I (2017) Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program. Life Sci. 172:55-63
Skeletal muscle development involves interactions between intracellular and extracellular factors that act in concert to regulate the myogenic process. Matrix gla protein (MGP), a well-known inhibitor of calcification in soft tissues, has been reported to be highly up-regulated during myogenesis. Our interest in the regulation of muscle satellite cells (MSCs) by extracellular matrix (ECM) led us to investigate the effects of MGP during the progression of myogenesis.
Animals; Calcium Channels, L-Type/metabolism; Calcium-Binding Proteins/physiology; Extracellular Matrix Proteins/physiology; Mice; Muscle, Skeletal/metabolism; Myostatin/metabolism
|Gene product||Qualifier||GO Term||Evidence Code||with/from||Aspect||Extension||Notes||Status|
|GO:0048644: muscle organ morphogenesis||
MGPkd cells show reduced MSTN expression, a negative regulator of muscle development, using both RT-PCR (mRNA) and Western Blot (protein). (Figure 3D)
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