GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:MGP

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MGP (synonyms: MGLAP)
Protein Name(s) Matrix Gla protein

MGP Cell growth-inhibiting gene 36 protein

External Links
UniProt P08493
EMBL M58549
M55270
X07362
X53331
AY542304
BT006733
CR450358
AK312029
DQ004248
AC007655
CH471094
BC005272
BC070314
BC093078
CCDS CCDS53752.1
CCDS8669.1
PIR A35811
RefSeq NP_000891.2
NP_001177768.1
UniGene Hs.365706
ProteinModelPortal P08493
BioGrid 110412
IntAct P08493
iPTMnet P08493
PhosphoSitePlus P08493
BioMuta MGP
DMDM 118572668
MaxQB P08493
PeptideAtlas P08493
PRIDE P08493
DNASU 4256
Ensembl ENST00000228938
ENST00000539261
GeneID 4256
KEGG hsa:4256
UCSC uc001rcn.3
CTD 4256
DisGeNET 4256
GeneCards MGP
HGNC HGNC:7060
HPA HPA013949
MalaCards MGP
MIM 154870
245150
neXtProt NX_P08493
OpenTargets ENSG00000111341
Orphanet 85202
PharmGKB PA30790
GeneTree ENSGT00390000003753
HOGENOM HOG000113581
HOVERGEN HBG006353
InParanoid P08493
KO K19481
OMA PFLNRRN
OrthoDB EOG091G0XPC
PhylomeDB P08493
TreeFam TF330920
ChiTaRS MGP
GeneWiki Matrix_gla_protein
GenomeRNAi 4256
PRO PR:P08493
Proteomes UP000005640
Bgee ENSG00000111341
CleanEx HS_MGP
ExpressionAtlas P08493
Genevisible P08493
GO GO:0070062
GO:0031012
GO:0005578
GO:0005509
GO:0005201
GO:0008147
GO:0001502
GO:0030154
GO:0001503
GO:0030500
InterPro IPR000294
IPR027118
IPR002384
PANTHER PTHR10109
PRINTS PR00002
SMART SM00069
SUPFAM SSF57630
PROSITE PS00011
PS50998

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048644

muscle organ morphogenesis

PMID:28012893[1]

ECO:0000315

P

MGPkd cells show reduced MSTN expression, a negative regulator of muscle development, using both RT-PCR (mRNA) and Western Blot (protein). (Figure 3D)

complete
CACAO 12928

enables

GO:0005201

extracellular matrix structural constituent

PMID:23979707[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(CL:0002543)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:27068509[3]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0007318)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:27559042[4]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

  • occurs_in:(UBERON:0006618)
  • occurs_in:(UBERON:0002302)

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:20551380[5]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001496)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27068509[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:23979707[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002543)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000294
InterPro:IPR035972

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000294
InterPro:IPR002384
InterPro:IPR035972

C

Seeded From UniProt

complete

involved_in

GO:0030500

regulation of bone mineralization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002384

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027118

C

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027118

C

Seeded From UniProt

complete

enables

GO:0008147

structural constituent of bone

PMID:9916809[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:9916809[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:9916809[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

PMID:9916809[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001502

cartilage condensation

PMID:9916809[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051216

cartilage development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0891

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0892

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Ahmad, S et al. (2017) Matrix gla protein: An extracellular matrix protein regulates myostatin expression in the muscle developmental program. Life Sci. 172 55-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
  3. ↑ 3.0 3.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  4. ↑ 4.0 4.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  5. ↑ 5.0 5.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  6. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Munroe, PB et al. (1999) Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Nat. Genet. 21 142-4 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:MGP&oldid=5956207"