GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:26399686
| Citation |
Noda, K, Nakamura, T and Komatsu, Y' (2015) Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice. Biochem. Biophys. Res. Commun. ' |
|---|---|
| Abstract |
Craniofacial sutures govern the shape of the craniofacial skeleton during postnatal development. The differentiation of suture mesenchymal cells to osteoblasts is precisely regulated in part by signaling through cell surface receptors that interact with extracellular proteins. Here we report that fibulin-5, a key extracellular matrix protein, is important for craniofacial skeletal development in mice. Fibulin-5 is deposited as a fibrous matrix in cranial neural crest-derived mesenchymal tissues, including craniofacial sutures. Fibulin-5-null mice show decreased premaxillary bone outgrowth during postnatal stages. While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative. Our study provides the first evidence that fibulin-5 is indispensable for the regulation of facial suture mesenchymal cell proliferation required for craniofacial skeletal morphogenesis. |
| Links |
PubMed Online version:10.1016/j.bbrc.2015.09.089 |
| Keywords |
|
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0098867: intramembranous bone growth |
ECO:0000315: |
P |
Figures 2 Figure 2 shows that there is specifically a defect in the premaxillary bone of Fibulin-5 knock out mice. (Uberon:0002244) |
complete | ||||
| GO:0097096: facial suture morphogenesis |
ECO:0000315: |
P |
Figure 4 E-G shows that a significant reduction of Ki67 immunostaining-positive cells in the PMMS (premaxillo-maxillary sutures) in Fibulin-5 KO mice was observed at P6. |
complete | ||||
| GO:0033690: positive regulation of osteoblast proliferation |
ECO:0000315: |
P |
Figure 4 A-G "...a significant reduction of Ki67-positive cells in KO mice was observed at P6 ( Fig. 4E–G). These data suggest that fibulin-5 deficiency has little effect on skeletogenic differentiation, but has significant impact on the proliferation of PMMS cells. Taken together, the premaxillary bone elongation defect seen in fibulin-5-null mice might be caused by the reduced cell proliferation in PMMS" |
complete | ||||
Notes
See also
References
See Help:References for how to manage references in GONUTS.
