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MOUSE:FBLN5

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Fbln5 (synonyms: Dance)
Protein Name(s) Fibulin-5

FIBL-5 Developmental arteries and neural crest EGF-like protein Dance

External Links
UniProt Q9WVH9
EMBL AF112151
AK085170
AK090129
AK159471
AK159960
AK165018
BC006636
CCDS CCDS36525.1
RefSeq NP_035942.1
UniGene Mm.288381
Mm.465863
ProteinModelPortal Q9WVH9
SMR Q9WVH9
IntAct Q9WVH9
MINT MINT-4094993
STRING 10090.ENSMUSP00000021603
MaxQB Q9WVH9
PaxDb Q9WVH9
PRIDE Q9WVH9
Ensembl ENSMUST00000021603
GeneID 23876
KEGG mmu:23876
UCSC uc007otp.2
CTD 10516
MGI MGI:1346091
eggNOG NOG309650
GeneTree ENSGT00760000118806
HOGENOM HOG000234337
HOVERGEN HBG051560
InParanoid Q9WVH9
KO K17340
OMA PRDIQLD
OrthoDB EOG7W9RTF
PhylomeDB Q9WVH9
TreeFam TF317514
Reactome REACT_332220
REACT_334317
ChiTaRS Fbln5
NextBio 303595
PRO PR:Q9WVH9
Proteomes UP000000589
Bgee Q9WVH9
CleanEx MM_FBLN5
Genevisible Q9WVH9
GO GO:0070062
GO:0031012
GO:0005576
GO:0005615
GO:0005578
GO:0005509
GO:0005178
GO:0008022
GO:0042803
GO:0007155
GO:0048251
GO:0030198
GO:0034394
GO:0001558
GO:2000121
GO:0046903
InterPro IPR026823
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR009030
Pfam PF12662
PF07645
SMART SM00179
SUPFAM SSF57184
PROSITE PS00010
PS01186
PS50026
PS01187

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0098867

intramembranous bone growth

PMID:26399686[1]

ECO:0000315

P

Figures 2 Figure 2 shows that there is specifically a defect in the premaxillary bone of Fibulin-5 knock out mice. (Uberon:0002244)

complete
CACAO 10991

GO:0097096

facial suture morphogenesis

PMID:26399686[1]

ECO:0000315

P

Figure 4 E-G shows that a significant reduction of Ki67 immunostaining-positive cells in the PMMS (premaxillo-maxillary sutures) in Fibulin-5 KO mice was observed at P6.

complete
CACAO 10994

GO:0033690

positive regulation of osteoblast proliferation

PMID:26399686[1]

ECO:0000315

P

Figure 4 A-G "...a significant reduction of Ki67-positive cells in KO mice was observed at P6 ( Fig. 4E–G). These data suggest that fibulin-5 deficiency has little effect on skeletogenic differentiation, but has significant impact on the proliferation of PMMS cells. Taken together, the premaxillary bone elongation defect seen in fibulin-5-null mice might be caused by the reduced cell proliferation in PMMS"

complete
CACAO 11061

GO:0016525

negative regulation of angiogenesis

PMID:17607303[2]

ECO:0000315

P

Figure 1 shows “in fbln5-/- mice, the vessel appeared to have an increased number of small, tortuous branches compared with fbln5+/- and wild-type mice. The overall length of the vessel measured between the start and end points, however, was unchanged (Figure 1e), suggesting that the increased number of vessels branching from the long thoracic artery of fbln5-/- mice was not a consequence of a longer vessel.”

complete
CACAO 11071

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:17607303[2]

ECO:0000315

P

Figure 4e and Figure 5a

complete
CACAO 11072

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:17607303[2]

ECO:0000315

P

Figure 5b: "ESE-1, was slightly downregulated in fbln5 -/- SMCs" Looking at the figure, mRNA expression is what is measured.

complete
CACAO 11133

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28071719[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0000006)

Seeded From UniProt

complete

enables

GO:0030023

extracellular matrix constituent conferring elasticity

PMID:28071719[3]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0000006)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:22159717[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002048)|part_of:(UBERON:0001155)

Seeded From UniProt

complete

enables

GO:0030023

extracellular matrix constituent conferring elasticity

PMID:22159717[4]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002048)|occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:24006456[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

produced_by:(CL:0002548)

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

PMID:11805835[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0048251

elastic fiber assembly

PMID:11805835[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UBX5

F

Seeded From UniProt

complete

involved_in

GO:0048251

elastic fiber assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9UBX5

P

Seeded From UniProt

complete

involved_in

GO:2000121

regulation of removal of superoxide radicals

PMID:15528465[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0071953

elastic fiber

PMID:11805834[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0048251

elastic fiber assembly

PMID:11805834[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034394

protein localization to cell surface

PMID:15528465[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:15528465[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UBX5

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048251

elastic fiber assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UBX5

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046903

secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UBX5

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UBX5

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030198

extracellular matrix organization

PMID:18757743[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UBX5

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2594

C

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBX5
ensembl:ENSP00000345008

C

Seeded From UniProt

complete

involved_in

GO:0048251

elastic fiber assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBX5
ensembl:ENSP00000345008

P

Seeded From UniProt

complete

involved_in

GO:0046903

secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBX5
ensembl:ENSP00000345008

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBX5
ensembl:ENSP00000345008

F

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UBX5
ensembl:ENSP00000345008

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVH8
ensembl:ENSRNOP00000007004

C

Seeded From UniProt

complete

involved_in

GO:0001558

regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVH8
ensembl:ENSRNOP00000007004

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037288

C

Seeded From UniProt

complete

involved_in

GO:0048251

elastic fiber assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037288

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-2426460

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Noda, K et al. (2015) Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice. Biochem. Biophys. Res. Commun. 466 585-91 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Sullivan, KM et al. (2007) Fibulin-5 functions as an endogenous angiogenesis inhibitor. Lab. Invest. 87 818-27 PubMed GONUTS page
  3. ↑ 3.0 3.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
  4. ↑ 4.0 4.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
  5. ↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
  6. ↑ 6.0 6.1 Nakamura, T et al. (2002) Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature 415 171-5 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Nguyen, AD et al. (2004) Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ. Res. 95 1067-74 PubMed GONUTS page
  8. ↑ 8.0 8.1 Yanagisawa, H et al. (2002) Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415 168-71 PubMed GONUTS page
  9. ↑ Manabe, R et al. (2008) Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U.S.A. 105 12849-54 PubMed GONUTS page
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