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PMID:25808493
| Citation |
'Groen, CM, Jayo, A, Parsons, M and Tootle, TL (2015) Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture. Mol. Biol. Cell ' |
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| Abstract |
Fascin, a highly conserved actin bundling protein, localizes and functions at new cellular sites in both Drosophila and multiple mammalian cell types. During Drosophila follicle development, in addition to being cytoplasmic, Fascin is in the nuclei of the germline-derived nurse cells during stages 10B-12 (S10B-12) and at the nuclear periphery during stage 13 (S13). This localization is specific to Fascin, as other actin binding proteins, Villin and Profilin, do not exhibit the same subcellular distribution. Additionally, localization of Fascin to the nucleus and nuclear periphery is observed in multiple mammalian cell types. Thus, the regulation and function of Fascin at these new cellular locations is likely to be highly conserved. In Drosophila, loss of prostaglandin signaling causes a global reduction in nuclear Fascin, and a failure to relocalize to the nuclear periphery. Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture. Given the numerous roles of Fascin in development and disease, including cancer, our novel finding that Fascin has functions within the nucleus sheds new light on the potential roles of Fascin in these contexts. |
| Links |
PubMed Online version:10.1091/mbc.E14-09-1384 |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
Colocalizes with |
GO:0034399: nuclear periphery |
ECO:0000314: |
C |
Figure 1: Live imaging of late stage follicles reveals GFP-Fascin, is in the nucleus during S10B-S12 (F-H) and at the nuclear periphery during S13 (I, J). |
complete | |||
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colocalizes_with |
GO:0034399: nuclear periphery |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
See also
References
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