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PMID:25591774
| Citation |
Li, Q, Li, N, Liu, CY, Xu, R, Kolosov, VP, Perelman, JM and Zhou, XD (2015) Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells. Cell. Physiol. Biochem. 35:326-38 |
|---|---|
| Abstract |
Increased mucin secretion is a characteristic feature of many chronic airway diseases, particularly during periods of exacerbation; however, the exact mechanism of mucin secretion remains unclear. Ezrin, which is a specific marker of apical membranes, is predominantly concentrated in exocyst-rich cell surface structures, crosslinking the actin cytoskeleton with the plasma membrane. In the present study, we examined whether Ezrin is involved in mucin 5AC (MUC5AC) secretion after neutrophil elastase (NE) attack, and we investigated the role of the exocyst complex docking protein Sec3 in this process. |
| Links |
PubMed Online version:10.1159/000369699 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005615: extracellular space |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(CL:0002368) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(CL:0002368) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048015: phosphatidylinositol-mediated signaling |
ECO:0000314: direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002368) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098592: cytoplasmic side of apical plasma membrane |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048015: phosphatidylinositol-mediated signaling |
ECO:0000314: direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002368) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050714: positive regulation of protein secretion |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
Notes
See also
References
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