PMID:24086476

Citation	Xue, Y, Shen, L, Cui, Y, Zhang, H, Chen, Q, Cui, A, Fang, F and Chang, Y (2013) Tff3, as a Novel Peptide, Regulates Hepatic Glucose Metabolism. PLoS ONE 8:e75240
Abstract	Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder strongly associated with hepatic glucose intolerance and insulin resistance. The trefoil peptides are a family of small regulatory proteins and Tff3 is widely expressed in multiple tissues including liver. But the roles of Tff3 in regulation of glucose metabolism and insulin sensitivity in liver remain unclear. Here we show that the hepatic Tff3 expression levels were decreased in ob/ob and high-fat diet-induced obese mice. Overexpression of Tff3 in primary mouse hepatocytes inhibited the expression of gluconeogenic genes, including G6pc, PEPCK and PGC-1α, subsequently decreasing cellular glucose output. GTT and ITT experiments revealed that adenovirus-mediated overexpression of Tff3 in diabetic or obese mice improved glucose tolerance and insulin sensitivity. Collectively, our results indicated that Tff3 peptides are involved in glucose homeostasis and insulin sensitivity, providing a promising peptide on new therapies against the metabolic disorders associated with T2DM.
Links	PubMed PMC3781022 Online version:10.1371/journal.pone.0075240
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:TFF3		GO:0010906: regulation of glucose metabolic process	ECO:0000314:		P		Figures 3,4, and 5 show how Tff3 regulates glucose metabolism by decreasing the amount of blood glucose and increases glucose tolerance in different types of mice.	complete CACAO 8778
MOUSE:TFF3	involved_in	GO:0010906: regulation of glucose metabolic process	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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