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PMID:23973664
| Citation |
Gemelli, C, Martello, A, Montanari, M, Zanocco Marani, T, Salsi, V, Zappavigna, V, Parenti, S, Vignudelli, T, Selmi, T, Ferrari, S and Grande, A (2013) The Orosomucoid 1 protein is involved in the vitamin D - mediated macrophage de-activation process. Exp. Cell Res. 319:3201-13 |
|---|---|
| Abstract |
Orosomucoid 1 (ORM1), also named Alpha 1 acid glycoprotein A (AGP-A), is an abundant plasma protein characterized by anti-inflammatory and immune-modulating properties. The present study was designed to identify a possible correlation between ORM1 and Vitamin D3 (1,25(OH)2D3), a hormone exerting a widespread effect on cell proliferation, differentiation and regulation of the immune system. In particular, the data described here indicated that ORM1 is a 1,25(OH)2D3 primary response gene, characterized by the presence of a VDRE element inside the 1kb sequence of its proximal promoter region. This finding was demonstrated with gene expression studies, Chromatin Immunoprecipitation and luciferase transactivation experiments and confirmed by VDR full length and dominant negative over-expression. In addition, several experiments carried out in human normal monocytes demonstrated that the 1,25(OH)2D3--VDR--ORM1 pathway plays a functional role inside the macrophage de-activation process and that ORM1 may be considered as a signaling molecule involved in the maintenance of tissue homeostasis and remodeling. |
| Links |
PubMed Online version:10.1016/j.yexcr.2013.08.017 |
| Keywords |
Gene Expression Profiling; HL-60 Cells; Humans; Macrophage Activation/drug effects; Macrophages/drug effects; Macrophages/metabolism; Orosomucoid/genetics; Orosomucoid/isolation & purification; Orosomucoid/metabolism; U937 Cells; Vitamin D/pharmacology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0032715: negative regulation of interleukin-6 production |
ECO:0000314: |
P |
Figure 8: Transcript analysis from cells with ORM 1 stimulation vs cells that are not ORM 1 stimulated. Less interleukin 6 transcript is made in the with ORM 1 stimulation. |
complete | ||||
| GO:0032720: negative regulation of tumor necrosis factor production |
ECO:0000314: |
P |
Figure 8: Cells that are treated with ORM 1 stimulant for 48 hours or longer produce less TNF alpha than when no stimulation of ORM 1 is induced. |
complete | ||||
|
involved_in |
GO:0032715: negative regulation of interleukin-6 production |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032720: negative regulation of tumor necrosis factor production |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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