GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:A1AG1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ORM1 (synonyms: AGP1) | |
| Protein Name(s) | Alpha-1-acid glycoprotein 1
AGP 1 Orosomucoid-1 OMD 1 | |
| External Links | ||
| UniProt | P02763 | |
| EMBL | X02544 M13692 X05779 X05780 X05781 X05782 X05783 X05784 X06676 X06680 BT019790 AK312035 AL356796 CH471090 BC104818 BC104820 BC143313 BC143314 BC026238 | |
| CCDS | CCDS6803.1 | |
| PIR | A28346 | |
| RefSeq | NP_000598.2 | |
| UniGene | Hs.522356 | |
| PDB | 3KQ0 | |
| PDBsum | 3KQ0 | |
| ProteinModelPortal | P02763 | |
| SMR | P02763 | |
| BioGrid | 111046 | |
| IntAct | P02763 | |
| MINT | MINT-202382 | |
| STRING | 9606.ENSP00000259396 | |
| BindingDB | P02763 | |
| ChEMBL | CHEMBL4285 | |
| DrugBank | DB05812 DB01418 DB01426 DB00802 DB00321 DB00543 DB01429 DB01156 DB08907 DB00482 DB00477 DB01151 DB00280 DB00590 DB01142 DB00530 DB00472 DB00317 DB00619 DB00458 DB08820 DB00934 DB08893 DB00731 DB00540 DB00334 DB00497 DB01359 DB00454 DB00946 DB08860 DB00457 DB00571 DB00908 DB01232 DB00864 DB00706 DB05521 DB01041 DB00656 DB05294 DB08881 DB08828 DB00682 | |
| PhosphoSite | P02763 | |
| UniCarbKB | P02763 | |
| DMDM | 112877 | |
| SWISS-2DPAGE | P02763 | |
| MaxQB | P02763 | |
| PaxDb | P02763 | |
| PeptideAtlas | P02763 | |
| PRIDE | P02763 | |
| DNASU | 5004 | |
| Ensembl | ENST00000259396 | |
| GeneID | 5004 | |
| KEGG | hsa:5004 | |
| UCSC | uc004bik.4 | |
| CTD | 5004 | |
| GeneCards | GC09P117085 | |
| HGNC | HGNC:8498 | |
| HPA | CAB006265 HPA046438 | |
| MIM | 138600 | |
| neXtProt | NX_P02763 | |
| PharmGKB | PA260 | |
| eggNOG | NOG41523 | |
| GeneTree | ENSGT00390000012130 | |
| HOGENOM | HOG000125170 | |
| HOVERGEN | HBG000035 | |
| InParanoid | P02763 | |
| KO | K17308 | |
| OrthoDB | EOG7B5WXT | |
| PhylomeDB | P02763 | |
| TreeFam | TF343791 | |
| ChiTaRS | ORM1 | |
| EvolutionaryTrace | P02763 | |
| GeneWiki | ORM1 | |
| GenomeRNAi | 5004 | |
| NextBio | 19272 | |
| PRO | PR:P02763 | |
| Proteomes | UP000005640 | |
| Bgee | P02763 | |
| CleanEx | HS_ORM1 | |
| Genevestigator | P02763 | |
| GO | GO:0072562 GO:0005576 GO:0005615 GO:0070062 GO:0006953 GO:0006954 GO:0002682 GO:0006810 | |
| Gene3D | 2.40.128.20 | |
| InterPro | IPR001500 IPR012674 IPR011038 IPR000566 | |
| PANTHER | PTHR11967 | |
| Pfam | PF00061 | |
| PIRSF | PIRSF036899 | |
| PRINTS | PR00708 | |
| SUPFAM | SSF50814 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000314 |
P |
Figure 8: Transcript analysis from cells with ORM 1 stimulation vs cells that are not ORM 1 stimulated. Less interleukin 6 transcript is made in the with ORM 1 stimulation. |
complete | |||||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000314 |
P |
Figure 8: Cells that are treated with ORM 1 stimulant for 48 hours or longer produce less TNF alpha than when no stimulation of ORM 1 is induced. |
complete | |||||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904469 |
positive regulation of tumor necrosis factor secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050718 |
positive regulation of interleukin-1 beta secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050716 |
positive regulation of interleukin-1 secretion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_output:(UniProtKB:P18510) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032720 |
negative regulation of tumor necrosis factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032715 |
negative regulation of interleukin-6 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072562 |
blood microparticle |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000239485 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002682 |
regulation of immune system process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006953 |
acute-phase response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1904724 |
tertiary granule lumen |
Reactome:R-HSA-6798745 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0035580 |
specific granule lumen |
Reactome:R-HSA-6798749 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031093 |
platelet alpha granule lumen |
Reactome:R-HSA-481007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6798749 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006953 |
acute-phase response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gemelli, C et al. (2013) The Orosomucoid 1 protein is involved in the vitamin D - mediated macrophage de-activation process. Exp. Cell Res. 319 3201-13 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Drenth, JP et al. (1996) Immunoglobulin D enhances the release of tumor necrosis factor-alpha, and interleukin-1 beta as well as interleukin-1 receptor antagonist from human mononuclear cells. Immunology 88 355-62 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 10.0 10.1 Dente, L et al. (1988) Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. Genes Dev. 2 259-66 PubMed GONUTS page
- ↑ Dente, L et al. (1987) Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J. 6 2289-96 PubMed GONUTS page
e
n
p
