PMID:23922907

Citation	Cazzonelli, CI, Vanstraelen, M, Simon, S, Yin, K, Carron-Arthur, A, Nisar, N, Tarle, G, Cuttriss, AJ, Searle, IR, Benkova, E, Mathesius, U, Masle, J, Friml, J and Pogson, BJ (2013) Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated development. PLoS ONE 8:e70069
Abstract	Plant-specific PIN-formed (PIN) efflux transporters for the plant hormone auxin are required for tissue-specific directional auxin transport and cellular auxin homeostasis. The Arabidopsis PIN protein family has been shown to play important roles in developmental processes such as embryogenesis, organogenesis, vascular tissue differentiation, root meristem patterning and tropic growth. Here we analyzed roles of the less characterised Arabidopsis PIN6 auxin transporter. PIN6 is auxin-inducible and is expressed during multiple auxin-regulated developmental processes. Loss of pin6 function interfered with primary root growth and lateral root development. Misexpression of PIN6 affected auxin transport and interfered with auxin homeostasis in other growth processes such as shoot apical dominance, lateral root primordia development, adventitious root formation, root hair outgrowth and root waving. These changes in auxin-regulated growth correlated with a reduction in total auxin transport as well as with an altered activity of DR5-GUS auxin response reporter. Overall, the data indicate that PIN6 regulates auxin homeostasis during plant development.
Links	PubMed PMC3726503 Online version:10.1371/journal.pone.0070069
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
ARATH:PIN6		GO:1901332: negative regulation of lateral root development	ECO:0000315:		P		Figure 2C and D- lateral root development is altered depending on PIN6 expression.	complete CACAO 8803
ARATH:PIN6		GO:0048767: root hair elongation	ECO:0000315:		P		Figure 4G&H- overexpression of PIN6 caused no root hair formation.	complete CACAO 8805
ARATH:PIN6		GO:0010105: negative regulation of ethylene-activated signaling pathway	ECO:0000315:		P		Figure 5	complete CACAO 8920
ARATH:PIN6		GO:0009926: auxin polar transport	ECO:0000315:		P		Figure 6A	complete CACAO 8921
ARATH:PIN6		GO:0010540: basipetal auxin transport	ECO:0000315:		P		Figure 6B	complete CACAO 8922
ARATH:PIN6	involved_in	GO:0010105: negative regulation of ethylene-activated signaling pathway	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:PIN6	involved_in	GO:0009926: auxin polar transport	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:PIN6	involved_in	GO:0048767: root hair elongation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:PIN6	involved_in	GO:0010540: basipetal auxin transport	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
ARATH:PIN6	involved_in	GO:1901332: negative regulation of lateral root development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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