PMID:23874955

Citation	Cizelsky, W, Hempel, A, Metzig, M, Tao, S, Hollemann, T, Kühl, M and Kühl, SJ (2013) sox4 and sox11 function during Xenopus laevis eye development. PLoS ONE 8:e69372
Abstract	SoxC genes are involved in many developmental processes such as cardiac, lymphoid, and bone development. The SoxC gene family is represented by Sox4, Sox11, and Sox12. Loss of either Sox4 or Sox11 function is lethal during mouse embryogenesis. Here, we demonstrate that sox4 and sox11 are strongly expressed in the developing eye, heart as well as brain in Xenopus laevis. Morpholino oligonucleotide mediated knock-down approaches in anterior neural tissue revealed that interference with either Sox4 or Sox11 function affects eye development. A detailed analysis demonstrated strong effects on eye size and retinal lamination. Neural induction was unaffected upon Sox4 or Sox11 MO injection and early eye field differentiation and cell proliferation were only mildly affected. Depletion of both genes, however, led independently to a significant increase in cell apoptosis in the eye. In summary, Sox4 and Sox11 are required for Xenopus visual system development.
Links	PubMed PMC3715537 Online version:10.1371/journal.pone.0069372
Keywords	Animals; Apoptosis/genetics; Brain/metabolism; Cell Proliferation; Cloning, Molecular; Eye/embryology; Eye/metabolism; Gene Expression Regulation, Developmental/genetics; Gene Expression Regulation, Developmental/physiology; In Situ Hybridization; In Situ Nick-End Labeling; Morpholinos/genetics; Myocardium/metabolism; SOXC Transcription Factors/metabolism; Statistics, Nonparametric; Xenopus Proteins/metabolism; Xenopus laevis/embryology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
XENLA:Q9DG48		GO:0048048: embryonic eye morphogenesis	ECO:0000315:		P		Figure 2A	complete CACAO 10503
XENLA:Q9DG48	involved_in	GO:0048048: embryonic eye morphogenesis	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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