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PMID:23300718
| Citation |
Bhat, KH, Ahmed, A, Kumar, S, Sharma, P and Mukhopadhyay, S (2012) Role of PPE18 protein in intracellular survival and pathogenicity of Mycobacterium tuberculosis in mice. PLoS ONE 7:e52601 |
|---|---|
| Abstract |
Ever since its discovery the mycobacterial proline-proline-glutamic acid (PPE) family of proteins has generated a huge amount of interest. Understanding the role of these proteins in the pathogenesis of Mycobacterium tuberculosis (Mtb) is important. We have demonstrated earlier that the PPE18 protein of Mtb induces IL-10 production in macrophages with subsequent downregulation of pro-inflammatory cytokines like IL-12 and TNF-α and favors a T-helper (Th) 2-type of immune response. |
| Links |
PubMed PMC3532481 Online version:10.1371/journal.pone.0052601 |
| Keywords |
Animals; Antigens, Bacterial/genetics; Antigens, Bacterial/metabolism; Antigens, Bacterial/physiology; Bacterial Load; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacterial Proteins/physiology; Female; Gene Knockout Techniques; Host-Pathogen Interactions; Liver/microbiology; Liver/pathology; Lung/microbiology; Lung/pathology; Male; Mice; Mice, Inbred C57BL; Microbial Viability; Mycobacterium tuberculosis/metabolism; Mycobacterium tuberculosis/pathogenicity; Mycobacterium tuberculosis/physiology; Spleen/microbiology; Spleen/pathology; Tuberculosis, Pulmonary/microbiology; Virulence |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0051701: biological process involved in interaction with host |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Figure 1: C57BL/6 mice were infected aerogenically with a low dose (1x10^8) of either WT or ppe18 KO strains of Mtb. At different time points post infection, mice were sacrificed and CFU counts were measured in lung (A), liver (B) and spleen (C). Lower CFU recovered of the ppe18 KO compared to WT in all three tissues. |
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Notes
See also
References
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